Clinical trials: Physical Function
Asthma Acute, Asthma in Children
User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients
The primary goal of this proposal is to use an in-home, smartphone-enabled, hand-held spirometer to determine the FEV1% predicted ranges that predict the Yellow Zone threshold.
- Conditions
- Asthma Acute, Asthma in Children, Asthma Chronic, Asthma Attack
- Trial name
- NCT03642418
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Constipation
Mechano-physiological Approach to Anorectal Function
We hypothesize that defecatory disorders can be described in mechanical terms which would allow a mechanistic description of disorders which would in turn allow better directed biofeedback mechanisms to treat disorders of…
- Trial name
- NCT00219518
- Testing
- defecography
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Septic Shock
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with…
- Trial name
- NCT00005890
- Testing
- corticotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Center for Research Resources (NCRR)
Diffuse Parenchymal Lung Disease
The Clinical Value of Serum KL-6 Changes on Evaluating Disease Development in Different Diffuse Parenchymal Lung Disease
Diffuse Parenchymal Lung Disease(DPLD) is a chronic progressive fibrosis lung disease that with a highly variable clinical process.Krebs von den Lungen-6 (KL-6) is a high-molecular-weight glycoprotein, classified as human MUC1…
- Trial name
- NCT03101397
- Where
- China
- Volunteers
- 180 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
Obstructive Sleep Apnea, Hypertension
Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea
This clinical research study will investigate the effects of respiratory strength training on blood pressure and cardiovascular health in adults who are 50 years of age and older and have been diagnosed with moderate or severe…
- Trial name
- NCT04932447
- Testing
- Inspiratory Muscle Strength Training
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Arizona
Executive Function
Fatty Acids and Executive Function Development in 7-12 Year Olds
Purpose: To examine the effect of the omega-6 to omega-3 fatty acid ratio on age-related changes in executive functions in children and older adults. Participants: Eighty-four typically-developing 7-to 12-year-old children.
- Trial name
- NCT02199808
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pulmonary Fibrosis
Lung Disease Associated With Rheumatoid Arthritis
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA).
- Trial name
- NCT00001876
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Stress Disorders, Post-Traumatic; Mental Disorders
PTSD Treatment for Veterans With Serious Mental Illness to Improve Functional Outcomes
PTSD is common among Veterans with serious mental illness (SMI). Co-occurring PTSD and SMI lead to poorer mental health and physical functioning than either diagnosis alone.
- Trial name
- NCT05674617
- Testing
- Written Exposure Therapy, PTSD Education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Endothelial Function, Hyperglycemia
Hyperglycemia, Exercise, and Endothelial Function
The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days.
- Trial name
- NCT03651713
- Testing
- GLU+EX, GLU
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hypertension, Pulmonary
The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH
Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved.
- Trial name
- NCT02647060
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- National Taiwan University Hospital
Sexual Function Disturbances, Myocardial Infarction
Improving Sexual Function After Myocardial Infarction
The study is completely digital. Men and women who recently had an MI will be invited through a written brochure that will be present in all Norwegian departments of cardiology.
- Trial name
- Sex/MI (NCT05312320)
- Testing
- Information film
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Sorlandet Hospital HF
Alzheimer's
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
This project explores Ginkgo biloba ester dispersible tablets influence on cognitive function in patients with mild-to-moderate elderly, to observe the effects of different intervention time on cognitive function, for alzheimer's…
- Trial name
- NCT03090516
- Testing
- Ginkgo biloba dispersible tablets, Donepezil, Ginkgo biloba dispersible tablets and Donepezil
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy
Effects of Phenolic Acids on Endothelial Function
Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate.
- Trial name
- NCT01772784
- Testing
- Phenolic acids
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
IgA Nephropathy (IgAN)
A Study of the Efficacy and Safety of Zigakibart + Atrasentan in Adult Patients With Primary IgA Nephropathy
This is a Phase IIIb, multicenter, two-arm, randomized, double-blind, parallel group study to evaluate the efficacy and safety of zigakibart + atrasentan compared to zigakibart + placebo in patients with primary IgAN at risk of…
- Trial name
- LUMINA IgAN (NCT07850752)
- Testing
- zigakibart, atrasentan
- Volunteers
- 340 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Virtual Reality in Physical Therapy in Multiple Sclerosis
The randomized controlled trial is aimed to study the efficacy of virtual reality (VR) and its impact on upper limb function and postural stability in people with mild to severe multiple sclerosis (pwMS).
- Trial name
- VIREMS (NCT04807738)
- Testing
- Neuroproprioceptive "facilitation and inhibition" in virtual reality, Neuroproprioceptive "facilitation and inhibition"
- Where
- 2 sites in Czechia
- Volunteers
- 71 people
- Sponsor
- Charles University, Czech Republic
Lower Urinary Tract Disorder
Pelvic Floor Muscle Activity, Respiratory Functions, Respiratory Muscle Strength, and Functional Capacity in Children With Lower Urinary Tract Dysfunction
The functional disorders of the lower urinary tract in children involve overactive bladder with thickening of the bladder muscle, resulting in a decrease in functional bladder volume and an increase in intra-bladder pressure.
- Trial name
- NCT06652178
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Non-small Cell Lung Cancer (NSCLC)
Efficacy of Argon-Helium Cryoablation Plus PD-1 Inhibitors in NSCLC
This randomized controlled trial investigated the efficacy and safety of argon-helium cryoablation combined with PD-1 inhibitors compared to PD-1 inhibitors plus chemotherapy for treating non-small cell lung cancer (NSCLC).
- Trial name
- NCT07053215
- Testing
- Argon-Helium Cryoablation, Camrelizumab, Platinum-based doublet chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Hospital of Hebei Medical University
Gait, Unsteady
At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery
This is a prospective observational study looking at gait-cadence in older adults who are scheduled to have major abdominal surgery at the University of Chicago.
- Trial name
- CADENCE (NCT05886725)
- Testing
- Patients using Step Test Application and Accelerometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago