Clinical trials: Physical Injury
Atrial Fibrillation
Medical Need of OAC Reversal
This is a retrospective, observational, claims cohort study to assess, for adult patients initiating an oral anticoagulant for NVAF
- Trial name
- NCT03254147
- Testing
- warfarin, dabigatran, Apixaban
- Where
- Japan
- Volunteers
- 53,969 people
- Sponsor
- Boehringer Ingelheim
Anterior Cruciate Ligament Rupture
Are Opioids Needed After ACL Reconstruction
As the public health sector continues to confront the opioid epidemic, orthopaedic surgeons must revisit pain management protocols to reduce unnecessary opioid prescriptions.
- Trial name
- NCT04285853
- Testing
- Oxycodone
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Emory University
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Muscle Wasting (Atrophy) After Hip Fracture Surgery
Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
The purpose of this study was to assess if bimagrumab is safe and effective in patients with muscle wasting (atrophy) after hip fracture surgery.
- Trial name
- NCT02152761
- Testing
- bimagrumab
- Where
- 53 sites in United States, Argentina and 17 more
- Volunteers
- 251 people
- Sponsor
- Novartis Pharmaceuticals
Muscle Atrophy, ACL Reconstruction
Testosterone Administration and ACL Reconstruction in Men
This study is being done to test whether taking testosterone can prevent loss of muscle mass and strength due to anterior cruciate ligament (ACL) reconstructive surgery.
- Conditions
- Muscle Atrophy, ACL Reconstruction, Trauma, Osteoarthritis
- Trial name
- TACL (NCT01595581)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Spinal Cord Injuries
ProACTIVE SCI Physical Activity Intervention
This study will employ a randomized, wait-list controlled trial. A total of 30 participants (15 experimental, 15 wait-list control) between 18-65 years of age who have chronic SCI ≥ 1 year prior will be recruited.
- Trial name
- NCT03111030
- Testing
- ProacTive SCI
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Brain Injuries, Traumatic
INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI)
The current study will evaluate the initial reliability and validity of a new instrument, the INTRuST Structured Assessment for Evaluation of TBI (SAFE-TBI), in three samples of Operation Enduring Freedom/Operation Iraqi…
- Trial name
- SAFE-TBI (NCT01554891)
- Where
- 6 sites in United States
- Volunteers
- 305 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Knee Injuries
Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions
Smith \& Nephew's first edition of the Journey posterior stabilizing total knee arthroplasty was analyzed by the Center for Musculoskeletal Research in a past research study, and it was determined that subjects experienced more…
- Trial name
- NCT02335710
- Testing
- Journey II BCS TKA
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Wound of Lower Leg (Physical Finding)
Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s)
This study evaluates the use of Prontosan® Wound Irrigation Solution and Prontosan® Wound Gel in the treatment of chronic leg wounds in adults.
- Trial name
- NCT03369756
- Testing
- Prontosan Wound Irrigation Solution and Prontosan Wound Gel
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- B. Braun Medical Inc.
Acute Orthopedic Injury
Toolkit for Optimal Recovery After Orthopedic Injury
This is a multi-site randomized feasibility trial of the Toolkit for Optimal Recovery after Orthopedic Injury (TOR), a mind-body program to prevent persistent pain and disability in at-risk patients with acute orthopedic injury…
- Trial name
- TOR (NCT04973696)
- Testing
- Toolkit for Optimal Recovery after Orthopedic Injury, Minimally Enhanced Usual Care (MEUC)
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Massachusetts General Hospital
Distal Radius Fracture, Post Operative Pain Control
Single Shot vs Catheter Infraclavicular Brachial Plexus Block After Distal Radius Fracture Repair
The purpose of this study is to compare infraclavicular brachial plexus shot single shot block to continuous catheter nerve block done in adult patients who have under gone surgery to repair distal radius fractures.
- Trial name
- NCT02744352
- Testing
- 20ml bolus of 0.5% ropivicaine, 0.2% of ropivacaine at 8 milliliter/hour
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
PTSD
Yoga and Physical Activity for Veterans
Posttraumatic stress disorder (PTSD) is a major health problem for the nation's Veterans, leading to significant physical and mental health morbidity and mortality.
- Trial name
- NCT03509909
- Testing
- Hatha yoga, Supportive physical activity
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Diabetes, Wound Infection
Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of tedizolid (Sivextro, Merck \& Co.), a novel oxazolidinone antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic patients with lower limb wound…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620787
- Testing
- Tedizolid, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Pressure Ulcers, Spinal Cord Injuries
Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)
Pressure ulcers (PrUs) are the most frequent significant medical complication after spinal cord injury (SCI). PrU prevalence, morbidity, mortality, and recurrence rates are high, and most persons with SCI will have at least one…
- Trial name
- NCT00763282
- Testing
- Self Management (SM), Motivational Interviewing (MI), Education (ED)
- Where
- 5 sites in United States
- Volunteers
- 144 people
- Sponsor
- US Department of Veterans Affairs
Foot Injuries and Disorders
Ankle Foot Orthosis Comparative Effect
The proposed effort is designed to support evidence-based practice and optimal care by evaluating how the form, fit and function of two commercially available carbon fiber custom fit braces (Orthoses) influences outcomes…
- Trial name
- AFOCE (NCT03901053)
- Testing
- Reaktiv AFO, PhatBrace AFO
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Jason Wilken
Traumatic Brain Injury (TBI)
Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI
Background: Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage.
- Trial name
- NCT02504866
- Testing
- Vigorous exercise, Light to moderate exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati
Upper Extremity Wound, Lower Extremity Wound
VAC Bioburden Wound Care Assessment
The purpose of this study is to compare the microbiologic burden and need for further operative debridement of patients undergoing primary surgical debridement of infected tissue, soft tissue abscesses, or traumatic wounds of the…
- Conditions
- Upper Extremity Wound, Lower Extremity Wound, Soft Tissue Abscesses, Traumatic Wounds
- Trial name
- NCT04826965
- Testing
- Wound Vac is applied
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Arthralgia
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the body.
- Trial name
- NCT00111241
- Testing
- aromatase inhibitors (letrozole, anastrozole)
- Where
- Australia
- Volunteers
- 115 people
- Sponsor
- Monash University