Clinical trials: Physiology
Disability Evaluation, Recovery of Function
Effectiveness of VR Rehabilitation for People With Asymmetrical Gait Patterns
A randomized comparative study will be conducted to evaluate the rehabilitation process using a VR-based application versus conventional therapy in 40 patients (sample size determined using a sample size calculator).
- Conditions
- Disability Evaluation, Recovery of Function, Rehabilitation
- Trial name
- NCT07568821
- Testing
- Virtual Reality (VR) and Standard Rehabilitation, Standard Rehabilitation
- Volunteers
- 40 people
- Sponsor
- University of Rzeszow
Healthy Volunteers
Physiology of Volition Studied With Nerve Block
Background: The experience of volition that accompanies voluntary movement can be divided into the sense of will, or deciding to move, and the sense of agency, or feeling that the movement just made was self-generated.
- Trial name
- NCT01143506
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurogenic Bladder
Effect of Electroacupuncture at Different Acupoints on Bladder Function After Spinal Cord Injury
Neurogenic bladder after spinal cord injury can be divided into detrusor hyperreflexia and detrusor non reflexia. Acupuncture is recognized as a safe and effective treatment.
- Trial name
- NCT05262816
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Physiology
GLP-1 Signaling in Truncally Vagotomized Subjects
Investigation of the importance of vagal signaling for the glucohomeostatic effects of GLP-1. The study will include physiological studies of truncally vagotomized participants and matched controls.
- Trial name
- NCT02940184
- Testing
- Tablet Sitagliptin 100mg (evening before and morning of experiments), Intestinal Fructose administration
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Mechanical Ventilation Complication, Pulmonary Edema
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
- Trial name
- SystoWean (NCT05226247)
- Testing
- Spontaneous breathing trial
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Foot Diseases
Comparison of the Effects of Virtual Reality-Based Interventions on Foot Function, Foot Pressure, and Balance in Sedentary Individuals
Comparison of the Effects of Virtual Reality-Based Interventions on Foot Function, Foot Pressure, and Balance in Sedentary Individuals
- Trial name
- NCT07260747
- Testing
- VR Biodex Group, Video-Based VR Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Multiple Sclerosis
Hybrid Assistive Limb Application in Multiple Sclerosis Patients
The Hybrid Assistive Limb (HAL) exoskeleton detects bioelectrical signals from the muscles, responds to the intention of voluntary movement, and provides biological feedback.
- Trial name
- NCT07326852
- Testing
- Hybrid Assistive Limb (HAL)
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Ege University
Incisional Hernia
Impact Evaluation of Incisional Hernia on Muscular and Postural Function
Purpose of study is to assess perioperative functional parameters of the anterior abdominal wall muscles and postural control status in patients with large and giant incisional hernias in a controlled diagnostic study.
- Trial name
- IHMPF-1 (NCT05990647)
- Testing
- Dynamometric tension assessment, Postural balance, Assessment of the hernia defect size
- Where
- Uzbekistan
- Volunteers
- 95 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov
Sickle Cell Disease, Kidney Failure, Chronic
Kidney Function in Sickle Cell Anemia
This is a prospective clinical cohort study that involves a baseline study visit followed by up to 3 annual follow-up study visits for a total follow-up of 36-48 months to evaluate the age- and sex-adjusted rate of change in…
- Trial name
- NCT03277547
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Kenneth Ataga MD
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Metabolic Syndrome
Calorie Restricted Diet and Exercise
Calorie-restricted(CR) diet and exercise were effective to reduce Metabolic syndrome(MetS), however, its effect on knee functions for MetS patients with degenerate meniscus lesions(DMLs) was still poorly investigated.
- Trial name
- NCT05092178
- Testing
- calorie restricted diet and exercise, exercise alone
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Dyslipidemia, Renal Insufficiency
Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the Pharmacokinetics of ABT-335 and Rosuvastatin When Administered Concomitantly
Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the Pharmacokinetics of ABT-335 and Rosuvastatin When Administered Concomitantly
- Trial name
- NCT00585143
- Testing
- ABT-335, Rosuvastatin
- Where
- 6 sites in United States
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Epilepsy
Effects of Clobazam on Sleep and Daytime Function in Patients With Epilepsy
The purpose of this study is to monitor the effect of Clobazam on sleep and daytime alertness in people with Epilepsy.
- Trial name
- NCT02911025
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Knee
Effects of Digital-based Physical Activity Intervention in Individuals With Knee Osteoarthritis
Physical activity is recommended in the guidelines to improve pain and function in the treatment of knee OA, regardless of the severity of the disease, but still, patients rarely do enough physical activity.
- Trial name
- NCT05810376
- Testing
- Digital-based physical activity intervention, Patient education and exercise
- Volunteers
- 70 people
- Sponsor
- Trakya University
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Ecstasy (Drug), N-Methyl-3,4-Methylenedioxymethamphetamine
The NeXT Study; The Netherlands XTC Toxicity Study
The purpose of this study is to investigate the possible neurotoxic effects of the party-drug Ecstasy (MDMA)on brain and brain function in humans.
- Conditions
- Ecstasy (Drug), N-Methyl-3,4-Methylenedioxymethamphetamine, Psychopathology
- Trial name
- NCT00235768
- Where
- 3 sites in Netherlands
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Plantar Fasciitis
Effects of Foot-Core Strengthening and Sensorimotor Re-training With Routine Physical Therapy on Pain, Function, and Plantar Pressure in Patients With Plantar Fasciitis.
This study aims to compare the effects of foot core strengthening and sensorimotor re-training, each combined with routine physical therapy, on pain, functional ability, and plantar pressure in patients with Plantar Fasciitis.
- Trial name
- NCT07703111
- Testing
- Foot Core Strengthening with Routine Physical Therapy, Sensorimotor Re-training with Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Papillary Thyroid Cancer
A Study to Try to Bring Back Radioiodine Sensitivity in Patients With Advanced Thyroid Cancer.
Thyroid cancers that have spread beyond the neck are not curable. About 30,000 people worldwide die from thyroid cancer every year.
- Trial name
- NCT03469011
- Testing
- Imatinib Oral Tablet
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- AHS Cancer Control Alberta
T Cell Response to Dried Plum, Vitamin D Influence on Immune Response
Prebiotics (Dried Plum) and Immune Function in Postmenopausal Women
Prior studies have shown that dietary supplementation with dried plums (also known as prunes) reduces bone loss in postmenopausal women.
- Conditions
- T Cell Response to Dried Plum, Vitamin D Influence on Immune Response, Dried Plum and Immune Function
- Trial name
- NCT07222111
- Testing
- Dried plums
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University