Clinical trials: Physiopathology
Metabolic Associated Fatty Liver Disease
Supplementation With Alpha-lipoic Acid and Silybum Marianum(LUDLEV®) for the Improvement of Fatty Liver Disease
This randomized, controlled, double-blind study evaluates the utility of alpha-lipoic acid and silybum marianum , versus placebo, in the treatment of metabolic associated fatty liver disease.
- Trial name
- NCT05913986
- Testing
- LUDLEV®300 mg/46.2 mg
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Saluz Investigación S. C.
Cognitive Impairment, Brain Fog
A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Performance
This study evaluates the effects of the Xula Herbs Mind Food supplement on cognitive performance in adults aged 25-70 who report difficulty concentrating, memory challenges, brain fog, and low productivity.
- Conditions
- Cognitive Impairment, Brain Fog, Memory Difficulties, Difficulty Concentrating
- Trial name
- NCT07742605
- Testing
- Xula Herbs Mind Food Supplement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Xula Wellness LLC
Chagas' Disease (Chronic) With Other Organ Involvement
Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
Chagas disease is one of the most neglected vector-borne infectious disease worldwide. The first decades following the discovery of the pathology drove an international research enthusiasm, mainly concentrated on understanding…
- Trial name
- NCT03189056
- Testing
- Chagas serology, Creatinina, Urodynamic exploration
- Where
- Bolivia
- Volunteers
- 152 people
- Sponsor
- Institut de Recherche pour le Developpement
Erectile Dysfunction
A Clinical Trial to Investigate the Efficacy and Safety of Tongkat Ali Maca Plus
This was a randomized, double blind, placebo-controlled, Three-arm, multicenter, parallel groups, interventional phase II clinical trial evaluating the efficacy, and safety of a herbal medicinal product of dried roots of Eurycoma…
- Trial name
- NCT05347329
- Testing
- Tongkat Ali Maca Plus
- Where
- Egypt
- Volunteers
- 197 people
- Sponsor
- Natural Wellness Egypt
Cancer Therapy-Related Cardiac Dysfunction, Heart Failure
Risk Stratification of Cancer Therapy-Related Cardiac Dysfunction Using AI-Enhanced Electrocardiography
This study investigates the use of AI-enhanced electrocardiogram (ECG) for risk stratification of cancer therapy-related cardiac dysfunction (CTRCD) before the initiation of cancer therapy.
- Conditions
- Cancer Therapy-Related Cardiac Dysfunction, Heart Failure, Left Ventricular Dysfunction
- Trial name
- NCT07515859
- Testing
- No intervention (retrospective observational study)
- Where
- South Korea
- Volunteers
- 31,486 people
- Sponsor
- Yonsei University
Detrusor Underactivity, Bladder Outlet Obstruction
DU and BOO in Women With and Without Symptoms of VD
Women with symptoms of voiding dysfunction may be associated with detrusor underactivity or bladder outlet obstruction. However, the prevalence of detrusor underactivity and bladder outlet obstruction remained obscure.
- Trial name
- NCT04981080
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 1,886 people
- Sponsor
- National Taiwan University Hospital
Erectile Dysfunction
A Study to Evaluate Self-esteem and Relationships in Males With Erectile Dysfuntion
To determine the improvement in the self-esteem domain score of the Self-Esteem/Overall Relationship (SEAR) questionnaire and the improvement in erectile function (obtained from the Erectile Function [EF] domain of the…
- Trial name
- NCT00648596
- Testing
- sildenafil
- Where
- 66 sites in Finland, France and 6 more
- Volunteers
- 780 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Dementia, Traumatic Brain Injury (TBI)
Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI)…
- Conditions
- Dementia, Traumatic Brain Injury (TBI), Mild Cognitive Impairment (MCI), Chronic Traumatic Encephalopathy (CTE)
- Trial name
- NCT01891383
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Asthma, Respiratory Disease
Symptoms, Respiratory Dysfunction and Frailty Level in Allergic and Eosonophilic Asthmatics
The aim of this study is to determine the level of respiratory dysfunction, symptoms and frailty in patients with asthma according to different endophenotypes (allergic and eosonophilic asthma).
- Conditions
- Asthma, Respiratory Disease, Fragility
- Trial name
- NCT06796894
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Quality of Life, Pacemaker Ddd Permanent
Clinical Benefit of Rigourous AV Delay Optimization in Patients With a Dual Chamber Pacemaker
Though AV optimization has become a cornerstone in optimization of patients with a cardiac resynchronization therapy (CRT) device, surprisingly the use of AV optimization in patients with a dual chamber (bicameral (BIC))…
- Conditions
- Quality of Life, Pacemaker Ddd Permanent, Atrial Dysfunction
- Trial name
- CBRAVO (NCT01998256)
- Testing
- AV optimization
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Jessa Hospital
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery Requiring Extracorporeal Circulation
Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac Surgery
Cardiac Surgery and Acute Kidney Failure (AKI) post Surgery: AKI is a frequent complication in the immediate aftermath of cardiac surgery with an incidence varying from 5 to 40%.
- Trial name
- MIT-CEC (NCT04125069)
- Testing
- Coronary Artery Bypass Graft (CABG)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital Center of Martinique
End Stage Renal Failure on Dialysis, Complication of Hemodialysis
Study of Inflammation and Oxidative Stress in Persons Undergoing Dialysis
Little is known about how some drugs affect inflammation or clotting factors in people receiving hemodialysis. It is not yet known if these drugs help prevent heart damage as they do in people not undergoing hemodialysis or…
- Trial name
- NCT00732069
- Testing
- Ramipril, Valsartan
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University
ST Segment Elevation Myocardial Infarction
Early Intracoronary Administration of Fasudil in the Primary PCI of ST-segment-Elevation Myocardial Infarction
The study aims to evaluate whether an early intracoronary administration of Fasudil Hydrochloride during primary PCI of STEMI can improve epicardial and myocardial perfusion as well as clinical outcomes.
- Trial name
- NCT03753269
- Testing
- Fasudil Hydrochloride
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Psychological Stress, Mental Fatigue
A Multi-Dimensional Comparative Study of Exercise Psychological Experience Under AI Fitness Companion and Human Coach Paradigms
This study conducted a comparative analysis of subjective exercise experiences between an AI-based fitness companion and traditional human coaching among 98 university students participating in a standardized 20-minute functional…
- Conditions
- Psychological Stress, Mental Fatigue, Cognitive Dysfunction, Emotional Well-being
- Trial name
- NCT07690553
- Testing
- AI-Based Companion, Human-Coached
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Mild Cognitive Impairment
Memory Training in Patients With Amnestic Mild Cognitive Impairment
Preview research reports evidence of cognitive plasticity among individuals with amnestic Mild cognitive Impairment, and small-size studies have suggest that this population can benefit from memory training.
- Trial name
- NCT01978353
- Testing
- Memory Training, Psychoeducation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Mild Cognitive Impairment
Effects of Memory Boot Camp on Brain Function in Adults With Symptoms of Mild Cognitive Impairment (MCI)
This is a prospective controlled clinical trial to determine the effects of a 12-week Memory Boot Camp (MBC) program on cognitive function in older adults with symptoms of Mild Cognitive Impairment.
- Trial name
- NCT04426162
- Testing
- Multi-domain Intervention
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Neurocore
Radiation Disease
Pelvic Radiation Disease in Childhood Cancer Survivors
This study aims to characterise the impact of radiotherapy on physical symptoms and quality of life in childhood and young adult cancer survivors.
- Trial name
- NCT05533541
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Female Sexual Arousal Disorder, Female Sexual Dysfunction (FSD)
Evaluation of the Efficacy in Increasing Sexual Arousal, Safety and Tolerability of BZ371A in Women With Sexual Arousal Disorder
Evaluation of the efficacy in increasing sexual arousal, safety and tolerability of BZ371A in gel form applied to women with sexual arousal disorder
- Trial name
- NCT06651541
- Testing
- BZ371A (0.5 ml), BZ371A (1.0 ml)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Biozeus Biopharmaceutical S.A.
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