Clinical trials: Physiopathology
Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis
Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology
The EXPAND study is a prospective observational study designed to investigate the biological mechanisms underlying the heterogeneity of type 2 diabetes and related metabolic disorders.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis, Prediabetes, Pancreatic Neoplasms
- Trial name
- EXPAND (NCT07670871)
- Volunteers
- 440 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer Female, Sexual Dysfunction
Sexual Dysfunction Check-up in Premenopausal Breast Cancer Survivors Taking Endocrine Therapy: A Cross-Sectional Study
Primary objectives: To estimate Sexual Dysfunction (SD) incidence in premenopausal breast cancer patients treated by surgery and taking endocrine therapy.
- Conditions
- Breast Cancer Female, Sexual Dysfunction, Premenopausal Breast Cancer
- Trial name
- SEXCHECK (NCT06458764)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Candiolo Cancer Institute - IRCCS
Dementia, Cognitive Disorders
Remote Cognitive Multidomain Assessment in People With Cognitive Disorders
Digital medicine is a useful clinical resource for people with cognitive disorders. Scientific literature has shown that in people with dementia neuropsychological instruments administered in remote are characterized by high…
- Conditions
- Dementia, Cognitive Disorders, Neuropsychological Tests, Cognitive Assessment
- Trial name
- NCT06078332
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Cognitive Impairment, Executive Dysfunction
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and…
- Conditions
- Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT02122198
- Testing
- Leuprolide acetate, Estradiol, Medroxyprogesterone
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Stress Disorders, Post-Traumatic, Depression
Neuropsychological Impact of Hospitalization on Intubated, Ventilated and Sedated ICU Patients
This is a prospective, single-center, pilot, cohort study. The first phase of this study is observational and the usual care of patients is maintained during the ICU stay, except for an interview with a psychologist preceding…
- Trial name
- NeuroPsy Réa (NCT01838798)
- Testing
- Baseline activities, Clinical interview with a psychologist, Telephone interview 2 months after ICU discharge
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Microvascular Coronary Dysfunction, Cardiovascular Disease
WISE CVD - Continuation (WISE HFpEF)
The Women's Ischemia Study Evaluation (WISE), a cohort study of over 1000 women, has made many contributions to the understanding of cardiovascular disease.
- Trial name
- NCT02582021
- Testing
- Coronary Angiography, Coronary Reactivity Testing, Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Cedars-Sinai Medical Center
Erectile Dysfunction
A Study to Compare the Blood Levels of Sildenafil Following Administration of an Experimental Tablet vs. the Conventional Oral Tablet in Healthy Subjects
This study to will compare the blood levels of sildenafil following administration of an experimental tablet vs. the conventional oral tablet.
- Trial name
- NCT00866463
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy, Cognitive Impairment
Post Hoc Analysis and Clinical Data Collection for Subjects Tested With Brain Network Activation (BNA™) Technology
The study is designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical assessments and BNA scores.
- Conditions
- Healthy, Cognitive Impairment, Neurological Disorder
- Trial name
- NCT03699514
- Testing
- Brain Network Activation (BNA™) technology
- Where
- 4 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Breast Cancer
Exercise, Cancer and Cognition: The ECCO-Study
The "ECCO"-study evaluates the efficacy of simultaneous controlled exercise during neo/-adjuvant chemotherapy in breast cancer patients and its effects on neurocognition.
- Trial name
- ECCO (NCT04789187)
- Testing
- High-Intensity-Interval-Training, General Physical Activity Recommendations
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Johannes Kepler University of Linz
Type 2 Diabetes, Insulin Resistance
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
- Trial name
- T2DM (NCT06912321)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Mild Cognitive Impairment
Effect of Ginkgo Biloba Special Extract LI 1370 on Dual-tasking in Patients With MCI
The aim of this study is to evaluate the effects of Ginkgo Biloba Extract (GBE) in executive function-impaired Mild Cognitive Impairment (MCI) patients by assessing gait while walking alone as well as under differing dual-task…
- Trial name
- NCT01046292
- Testing
- Ginkgo biloba
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Erectile Dysfunction
Energy Specific Far Infrared Radiation Treatment for Erectile Dysfunction
A preliminary study to determine the possibility of using far infrared (FIR) radiation to treat impotency.
- Trial name
- NCT00573209
- Testing
- Far Infrared Radiation
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- GAAD Medical Research Institute Inc.
Female Sexual Dysfunction
Cognitive-Behavioural & Mindfulness-Based Online Programs for Female Sexual Dysfunction
Female sexual dysfunction (FSD) affects approximately one-third of women worldwide and is linked to negative physical, psychological, and interpersonal outcomes.
- Trial name
- NCT05168371
- Testing
- Cognitive-Behavioural Therapy - Online (CBT-O), Mindfulness-Based Therapy - Online (MBT-O)
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University of British Columbia
Female Sexual Dysfunction, Multiple Sclerosis
Effects of Spinal Cord Injury on Female Sexual Response
The long term aims of this project are to 1) Understand the effect of varying degrees and levels of SCI and dysfunction(SCI/D)on females sexual response: 2) Identify the specific neuronal pathways involved in female sexual…
- Conditions
- Female Sexual Dysfunction, Multiple Sclerosis, Spinal Cord Injury
- Trial name
- NCT00142714
- Testing
- Sympathetic manipulation on sexual arousal in women
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cystinosis
The Effect of Exercise on Muscle Dysfunction in Cystinosis
Classification of activity tolerance is of importance in chronic progressive myopathies, not only to better understand functional implications of the disease state itself, but also for purposes of exercise prescription for health…
- Trial name
- NCT04071548
- Testing
- HIIT Exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Male Erectile Disorder, Prostate Cancer
Focal Therapy for Prostate Cancer Using HIFU
RATIONALE: Prospective trials using hemi-ablation with high intensity focused ultrasound (HIFU) (Sonablate 500) have demonstrated feasibility, safety, and encouraging functional outcomes and early cancer control with 90% of men…
- Conditions
- Male Erectile Disorder, Prostate Cancer, Therapy-related Toxicity, Urinary Incontinence
- Trial name
- INDEX (NCT01194648)
- Testing
- questionnaire administration, assessment of therapy complications, high-intensity focused ultrasound ablation
- Where
- United Kingdom
- Volunteers
- 354 people
- Sponsor
- University College, London
Respiratory Failure, Sepsis
Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients
Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the…
- Conditions
- Respiratory Failure, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- EA-ICUAW (NCT02204215)
- Testing
- electric acupuncture, conservative
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Hypertension, Cognitive Impairment
Validation of New Tools for the Assessment of Cognitive Functions and Connectivity Network in Hypertensive Patients
The relationship among hypertension, aging and cognitive decline is complex and not completely understood. Purpose of this project will be evaluating early markers of cognitive deterioration in patients with arterial…
- Trial name
- NCT02310217
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Neuromed IRCCS
Hydrocephalus
Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor
The study hypothesis is that an ultrasonic flow sensor can accurately measure flow in hydrocephalic shunts. The ultrasonic sensor will measure cerebro-spinal fluid drainage in hydrocephalus patients with external…
- Trial name
- NCT00652197
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Transonic Systems Inc.
Sevoflurane, Propofol
Sevoflurane, Propofol and Desflurane on POD/POCD
The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and…
- Conditions
- Sevoflurane, Propofol, Desflurane
- Trial name
- NCT03326960
- Testing
- Sevoflurane, Propofol, Desflurane
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.