Clinical trials: Physiopathology
Endometrial Dysfunction
Endometrial Receptivity Profile in Patients With Endometrial Proliferation Defects
The purpose of this study is to determine the differences that exist in RNA molecules, the biochemical process of methylation, and estrogen receptor binding in patients that have failed to produce adequate endometrium in…
- Trial name
- NCT02406690
- Testing
- Estradiol Valerate, Progesterone in Oil, Leuprolide
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Mild Cognitive Impairment
Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year
Constituents of grapes have been studied for their antioxidant, anti-inflammatory, and anticarcinogenic properties. In the past decade, there has been emerging evidence regarding a potential role for grapes in slowing cognitive…
- Trial name
- NCT03361410
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Sepsis With Acute Organ Dysfunction
Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis
Septic shock is still a major cause of death in ICU. Sepsis diagnosis is linked with many clinical, hemodynamic and biological criteria which have a low sensitivity and specificity if they are considered separately.
- Trial name
- SEPTIFLUX2 (NCT01995448)
- Testing
- Blood test
- Where
- 9 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Limoges
Delirium, Postoperative Cognitive Dysfunction
Biomarkers Associated With Postoperative Cognitive Dysfunction
Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed…
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- NCT05464355
- Testing
- Intraoperative electroencephalography recording, Neurofilament light chain measurement, Tau protein measurement
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Frail Elderly, Cognitive Impairment
Effectiveness of a Multifactorial Intervention on Frailty
Objective: To evaluate the effectiveness of a multifactorial intervention program based on physical activity and diet, memory workshops and review of medication, to modify frailty parameters, muscle strength and physical and…
- Conditions
- Frail Elderly, Cognitive Impairment, Dependence
- Trial name
- NCT01969526
- Testing
- Multifactorial intervention
- Where
- Spain
- Volunteers
- 352 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Hyperglycaemia During Perioperative Period, Heart Valve Diseases
Glucose Control in Open Heart Surgery
The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery
- Conditions
- Hyperglycaemia During Perioperative Period, Heart Valve Diseases, Ventricular Dysfunction
- Trial name
- NCT00370643
- Testing
- human regular insulin
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
Erectile Dysfunction Following Radical Prostatectomy
Low-Intensity Extracorporeal Shockwave Therapy for Penile Rehabilitation in Post-Radical Prostatectomy Patients
Radical prostatectomy (RP) is one of the curative treatment modalities for localized or locally advanced prostate cancer. Urinary incontinence and erectile dysfunction (ED) are two most common complications after RP.
- Trial name
- NCT06076850
- Testing
- Low-Intensity Extracorporeal Shockwave Therapy (LiEWST) - Active
- Where
- Malaysia
- Volunteers
- 70 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Chronic Obstructive Pulmonary Disease
Involvement of Nervous System in Muscle Weakness in COPD Patients
The purpose of this study is to determine whether nervous system alterations and motor drive failure can contribute to muscle weakness in COPD during voluntary movement.
- Trial name
- DesCoM-1 (NCT01679782)
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Hypertension
Targeting Microvascular Dysfunction in Young Hypertensive Patients
Cholesterol and blood pressure lowering tablets have been shown to be of benefit in patients with established high blood pressure.
- Trial name
- NCT01047423
- Testing
- Simvastatin
- Where
- United Kingdom
- Sponsor
- Queen's University, Belfast
Scoliosis Idiopathic, Vestibular Function Disorder
Evaluation of Vestibular Dysfunction or Visuospatial Perception in Individuals With Idiopathic Scoliosis
This study was planned to investigate whether there is a visual-spatial perception disorder in individuals with idiopathic scoliosis and also to reveal its dependent/independent relationship with vestibular dysfunction.
- Conditions
- Scoliosis Idiopathic, Vestibular Function Disorder, Visuospatial/Perceptual Abilities
- Trial name
- NCT05045014
- Testing
- Balance assessment, Unterberger test, Corsi Block Tapping (mobıl app)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pelvic Pain, Levator Ani Syndrome
Photobiomodulation for Myofascial Pelvic Pain
The goal of this clinical trial is to evaluate the efficacy of photobiomodulation of the pelvic floor muscles in female Veterans with chronic pelvic pain.
- Conditions
- Pelvic Pain, Levator Ani Syndrome, Spastic Pelvic Floor Syndrome, Chronic Pelvic Pain Syndrome
- Trial name
- PMPP (NCT05926752)
- Testing
- SoLá therapy, Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Orlando VA Medical Center
Environmental Enteric Dysfunction
Lactoferrin and Lysozyme Supplementation for Environmental Enteric Dysfunction
Randomized, double-blind, placebo controlled trial of daily lactoferrin and lysozyme supplementation in improving environmental enteric dysfunction in Malawian children
- Trial name
- NCT02925026
- Testing
- Lactoferrin, Lysozyme
- Where
- Malawi
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Myocardial Dysfunction
Trans-thoracic Ultrasound VS Invasive Pressure of the Left Atrium
As part of cardiac and hemodynamic evaluation of patients, echocardiographic measurements allow indirect evaluation of left ventricular filling pressures (LVFP).
- Trial name
- ECHOPOG (NCT03012308)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Rechargeable Sacral Neuromodulation Device, Neurogenic Lower Urinary Tract Dysfunction
Cost Profile and Budget Implications of Rechargeable Versus Non-rechargeable Sacral Neuromodulation Devices for Neurogenic Lower Urinary Tract Dysfunction
Traditional sacral neuromodulation devices are not rechargeable. In recent years, new rechargeable sacral neuromodulation devices have been developed and put into the market.
- Trial name
- SNM、NLUTD (NCT07173517)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure
Trial of Education and Compliance in Heart Dysfunction (TEACH)
The emphasis of this grant is to investigate ways to educate patients, not only to improve their knowledge about medications and diet that are important for better outcomes in heart failure, but also to try to understand how…
- Trial name
- NCT00211289
- Testing
- Education by community pharmacist
- Where
- 2 sites in Canada
- Volunteers
- 383 people
- Sponsor
- London Health Sciences Centre
Sclerosis, Multiple
Exploration of Microcirculatory Alteration and Endothelial Dysfunction by Adaptive Optics in Multiple Sclerosis
It's a pilot, interventional prospective monocentric study. It aims to compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between patients with multiple sclerosis and controls using…
- Trial name
- MS-EYE (NCT03508089)
- Testing
- Ocular fundus on patient with Multiple Sclerosis, Ocular Fundus on voluntary person
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Versailles Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
GERD
Gastric Neuromuscular Function in GERD
Bodysurface gastric mapping (BSGM) will be used to assess gastric neuromuscular function in healthy controls and patients with medical refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT05719168
- Testing
- Body Surface Gastric Mapping
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
Voiding Dysfunction
The Measurement of Bladder Impedance and Heart Rate During Urodynamic Study
Purpose To measure the impedance of the bladder during the urodynamic study to see if changes in the impedance value occur as the bladder volume changes in pediatric patients aged 5-12 years along with its leg time.
- Trial name
- NCT04010591
- Testing
- impedance measurement during urodynamic study
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
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