Clinical trials: Physiopathology
Respiratory Symptoms, Autonomic Nervous System Dysfunction
CoVID-19 Evaluation of Neurological and Autonomic Nervous System Troubles in Intensive Care Unit Patients
Since the spread of the COVID-19 disease, several studies have reported the presence of neurological symptoms in patients infected with SARS-CoV-2 such as dysgeusia, hypo or anosmia, hypopsia, the presence of headaches or…
- Trial name
- COVENANT-ICU (NCT06060795)
- Testing
- Electro-conductance measurement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Metabolic Syndrome
Exercise and Carotid Artery Function in Metabolic Syndrome
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely…
- Trial name
- NCT07430839
- Testing
- exercise, Diagnostics, Inhaled CO2-mixed air
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Physical Activity, Functional Disturbance
Effects of Dextrose on Knee Osteoarthritis
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined dextrose injection to…
- Trial name
- NCT03238183
- Testing
- dextrose, hyaluronic acid
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Multiple Organ Dysfunction Syndrome
The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome
The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality.
- Trial name
- NCT01802983
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Chinese PLA General Hospital
Mild Cognitive Impairment, Mild Cognitive Impairment Due to Alzheimer's Disease
UK Based Remote Brain Health Clinic (BHC) for Patients With Mild Cognitive Impairment (MCI)
This project aims to understand the feasibility, acceptability and real-world evidence of a novel UK-based remote brain health clinic for patients with mild cognitive impairment (MCI).
- Trial name
- BHC (NCT06379594)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Sleep Apnea
Cardiac Dysfunction in Obstructive Sleep Apnea Patients: Prevalence of and Effect of nCPAP
The aim of this study is to clarify the influence of obstructive sleep apnea syndrome on left ventricular function using echocardiographic parameters including the myocardial performance index (Tei-index), and to determine the…
- Trial name
- NCT00503945
- Testing
- Nasal continuous positive airway pressure (nCPAP)
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Nagasaki University
Parkinson's Disease
A Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AVE8112 in Patients With Parkinson's Disease
This is a randomized, double-blind, placebo-controlled, multiple-ascending dose study of orally administered AVE8112 in patients with Parkinson's Disease (PD).
- Trial name
- NCT01803945
- Testing
- AVE8112
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Traumatic Brain Injury, Closed Head Injury
Photobiomodulation to Improve Cognition in TBI, With fMRI
The purpose of this small, research study is to examine effectiveness of an at-home application of an experimental intervention, on thinking and memory in mild-moderate, closed-head, traumatic brain injury cases.
- Conditions
- Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
- Trial name
- NCT04230577
- Testing
- Real LED Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston VA Research Institute, Inc.
Sepsis, Liver Failure
Lactate Clearance According to the Presence of Hepatic Dysfunction
The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.
- Trial name
- NCT01709565
- Where
- South Korea
- Volunteers
- 245 people
- Sponsor
- Samsung Medical Center
Constipation
Impact of Laxative Therapy With Lactulose in the Evolution of Organ Dysfunction in Critically Ill Patients.
MAIN FEATURES OF THE STUDY: therapeutic intervention. Constipation is a frequent complication in critical ill patients. The disaccharide lactulose has a laxative osmotic activity.
- Trial name
- NCT01607060
- Testing
- Lactulone
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Federal University of São Paulo
Genitourinary Syndrome of Menopause, Pelvic Floor Dysfunction
Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in Women
Study objective: To evaluate the efficacy and safety of the Magic Max neodymium laser in the medical treatment of women with symptoms of genitourinary syndrome of menopausal, vulvar lichen sclerosus and pelvic floor muscle…
- Conditions
- Genitourinary Syndrome of Menopause, Pelvic Floor Dysfunction, Vulvar Lichen Sclerosus
- Trial name
- NCT05251220
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- 1st Federal Budgetary Healthcare Institution Volga District Medical Center
Community-Dwelling Older Adults, Aging
The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research
Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive…
- Conditions
- Community-Dwelling Older Adults, Aging, Cognitive Decline, Hand Dexterity
- Trial name
- NCT07315724
- Testing
- Technology-Assisted Block Training Program
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Cognitive Impairment
Maze Balance Board Training Effects on Mobility and Motor Skills in Cognitively Impaired Children
The study will be a Randomized Controlled Trial including 22 children aged 6-10 years with deficits in functional mobility and gross motor skills.
- Trial name
- NCT07578896
- Testing
- Maze Balance Board traing, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Metabolic Dysfunction-associated Steatotic Liver Disease
Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease
Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity.
- Trial name
- MYO-MASLD (NCT06506513)
- Testing
- High-intensity interval training, Moderate intensity exercise training, Low intensity exercise training
- Where
- 2 sites in Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Aspergillosis Invasive
Liposomal Amphotericin B in Invasive Aspergillosis With Hepatic Dysfunction
Liposomal amphotericin B is an antifungal agent commonly used to treat invasive aspergillosis, a severe fungal infection associated with high mortality in critically ill patients.
- Trial name
- NCT07337720
- Testing
- LIposomal amphotericin B (L-AmB) treatment
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Smell Dysfunction, Taste Disorders
The Study of Quadruple Therapy Intranasal Insulin, Zinc, Gabapentin, Ice Cube Stimulation for Post COVID-19 Smell and Taste Dysfunctions
post covid-19 smell and taste dysfunction are common globally and affect the quality of life and also have phycological impact and anxiety, also affect on economy as the patients not able to do cooking or buy prepared foods and…
- Conditions
- Smell Dysfunction, Taste Disorders, Taste Disorder, Secondary, Sweet, Taste Disorder, Secondary, Bitter
- Trial name
- COVID-19 (NCT05104424)
- Testing
- Insulin aspart
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Systemic Lupus Erythematosus
Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus
This study will examine the possible relationship between certain antibodies found in patients with systemic lupus erythematosus (SLE) and cognitive (thought processing) impairment in these patients.
- Trial name
- NCT00042523
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Cardiovascular Disease, Sarcopenia
Trial of Oral Glutamine on Mitochondrial Function in CKD
The primary goal of proposed investigation is to study the impact of oral glutamine supplementation on muscle mitochondrial and endothelial cell function measured mitochondrial energetics and vascular function using 31P magnetic…
- Conditions
- Cardiovascular Disease, Sarcopenia, Endothelial Dysfunction, Muscle Mitochondrial Function
- Trial name
- NCT02838979
- Testing
- First Intervention (14 days), Washout (3 weeks), Second Intervention (14 days)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Vulvovaginal Atrophy
Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareunia
The purpose of the study is to determine if WC3011 is safe and effective in treating the symptom of painful intercourse secondary to vulvovaginal atrophy as measured by participant self-assessment when compared to vehicle.
- Trial name
- NCT01845649
- Testing
- WC3011 Estradiol Vaginal Cream, Vehicle
- Where
- 57 sites in United States
- Volunteers
- 550 people
- Sponsor
- Warner Chilcott
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