Clinical trials: Physiopathology
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy
The TAKO-TSUBO And Cancer Registry
Prospective, multicenter, observational registry collecting data from subjects with Tako-Tsubo (stress-induced) cardiomyopathy (TTC).
- Conditions
- Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy, Acute Coronary Syndrome
- Trial name
- TTAC (NCT01944826)
- Testing
- Registry of patients with Tako-Tsubo cardiomyopathy
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cognitive Decline, Cognition Disorders in Old Age
The Effect of Blueberry Supplementation on Cognitive Functioning in Older Adults
In this randomized placebo controlled intervention study, the effect of 12 weeks of supplementation with either 150g whole blueberries, freeze-dried blueberry powder (dose equivalent to 150g berries) versus placebo on cognitive…
- Conditions
- Cognitive Decline, Cognition Disorders in Old Age, Aging
- Trial name
- BrainBerries (NCT07170943)
- Testing
- Blueberry, Freeze-dried blueberry powder
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wageningen University
Erectile Dysfunction
Phase 1 Study of SK3530 to Investigate of the Effect of Food
This study was designed to investigate the food effect of SK3530 on the pharmacokinetics (PKs).
- Trial name
- NCT00443625
- Testing
- SK3530
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- SK Chemicals Co., Ltd.
Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity
Non-Invasive Diagnostic Panel for MASLD in Children With Obesity
This prospective, single-center, two-group observational study evaluates a non-invasive multi-parameter diagnostic panel for metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Insulin Resistance Syndrome
- Trial name
- PedMASLD-Pilot (NCT07731360)
- Testing
- Non-Invasive Multi-Parameter Diagnostic Panel
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Kayseri City Hospital
Peripheral Arterial Disease
L-Citrulline in Peripheral Artery Disease
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with cardiovascular disease (CVD).
- Trial name
- CIPER (NCT02521220)
- Testing
- L-citrulline
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University
Mild Cognitive Impairment, Alzheimer Disease
Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2
To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Type2 Diabetes
- Trial name
- NCT03933696
- Testing
- Tailored Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Medication Adherence, Cognitive Impairment
Medication Dispenser to Improve Care at Home for the Elderly
The purpose of this study is to investigate the efficacy of the Karie Automated Medication delivery device in enhancing medication adherence among a group of elderly patients with mild to moderate cognitive decline.
- Trial name
- NCT03511027
- Testing
- SME + Karie Device, SME only
- Sponsor
- Lee Verweel
Chemo-brain
Treatment of Post-Chemo Cognitive Impairment w/Transcranial Magnetic Stimulation (Chemobrain TMS)
In this pilot study, the investigators propose to test the efficacy of rTMS for the treatment of PCCI. Efficacy measures will include baseline and post-rTMS neuropsychological testing, functional MRI and biometry data using body…
- Trial name
- NCT04295720
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arizona
Erectile Dysfunction
Drug-Drug Interaction (DDI) Study for TPN171H
The primary objective of this study was to assess the effect of rifampicin,a cytochrome P450 3A4 enzyme (CYP3A4) induction, on the pharmacokinetics (PK) of TPN171H in chinese healthy male subjects ,and assess the effect of…
- Trial name
- NCT06090123
- Testing
- TPN171H, Itraconazole, Rifampicin
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Cognitive Impairment
Changes in Cognition During a 24-h Simulated Military Operation
Sustained military operations (SUSOPs) result in psychological stress and cognitive dysfunction, which may be related to the recruitment of classical monocytes into the brain.
- Trial name
- NCT04250480
- Testing
- beta-alanine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
MASH, NASH
A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis
A randomized, double-blind, placebo-controlled Phase 3 study to determine if denifanstat 50 mg or 25 mg is effective, as compared to placebo, in resolving MASH without the worsening of fibrosis and/or in fibrosis regression…
- Conditions
- MASH, NASH, Metabolic Dysfunction-associated Steatohepatitis, Noncirrhotic Metabolic Dysfunction-associated Steatohepatitis
- Trial name
- FASCINATE-3 (NCT06594523)
- Testing
- Denifanstat
- Sponsor
- Sagimet Biosciences Inc.
Memory Impairment
The Effect of tES on a Cognitive Training
The aim of this study is to investigate the effect of a transcranial electrical stimulation (tES) on a cognitive training in healthy elderly and memory impaired participants.
- Trial name
- NCT03475446
- Testing
- real anodal tDCS healthy elderly, real tACS healthy elderly, real anodal tDCS MCI
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cognitive Impairment, Physical Disability
Circle Game Collaborative--Freddie the Frog
Families who have children with disabilities experience more challenges in interacting with their children than families who have children without disabilities.
- Trial name
- NCT05522946
- Testing
- Gameplay between parent and child or adolescent with or without a disability
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Sinus Node Dysfunction
Allometric-Pace Study
The goal of this observational study is to improve quality of life in sinus node dysfunction patients by utilizing allometric lower rate pacing (or called personalized lower rate, PLR) in standard commercially available…
- Trial name
- NCT05766462
- Testing
- Pacemaker lower rate setting
- Where
- 3 sites in China
- Volunteers
- 73 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Kidney Failure, Chronic
Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction
The purpose of this study is to compare renal toxicity of Iodixanol and Iopromide in patients with renal dysfunction.
- Trial name
- RIPE (NCT01580046)
- Testing
- iodixanol, iopromide
- Where
- 19 sites in China
- Volunteers
- 200 people
- Sponsor
- Yong Huo
Bladder Cancer Requiring Cystectomy, Erectile Dysfunction Following Radical Prostatectomy
Pilot Study of a New Nerve Grafting Method During Bladder Cancer Surgery to Help Preserve Erections.
This pilot study will evaluate the safety and 1-year erectile function recovery in 10 patients undergoing a novel Nerve Restoring Radical Cystectomy (NR-RC), which includes a genitofemoral nerve graft.
- Trial name
- NR-RC (NCT07140588)
- Testing
- Patients undergoing radical cystectomy will receive a novel NR-RC procedure using a genitofemoral nerve graft to enhance erectile function recovery.
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Upper Respiratory Tract Infections, Perioperative Respiratory Complications
Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia
The goal of this clinical trial is to determine whether intravenous (IV) lidocaine reduces the incidence of perioperative respiratory complications (PRCs) in children with upper respiratory tract infections undergoing general…
- Trial name
- NCT06584461
- Testing
- Lidocaine (drug)
- Where
- Tunisia
- Volunteers
- 102 people
- Sponsor
- Tunis University
Cognitive Dysfunction, Emergence Delirium
Effects of Hypothermia on Delayed Neurocognitive Recovery (DNR): an Observational Trial Among Patients Undergoing Cardiac-Surgery
Post-operative cognitive dysfunction is a common disease in patient undergoing general anaesthesia, especially in older patients.
- Conditions
- Cognitive Dysfunction, Emergence Delirium, Hypothermia
- Trial name
- DNR (NCT03636074)
- Testing
- Hypothermia during Extracorporeal Circulation
- Where
- Italy
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Padova
Intracranial Atherosclerosis, Cognitive Impairment
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study
The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on…
- Conditions
- Intracranial Atherosclerosis, Cognitive Impairment, Cerebrovascular Event
- Trial name
- NCT06336174
- Testing
- Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin, Endovascular therapy,Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
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