Clinical trials: Physiopathology
Gastrointestinal Dysfunction
Clinical Study on the Treatment of Gastrointestinal Dysfunction After Knee Joint Surgery Under General Anesthesia With Floating Needle
A randomized controlled trial was conducted to compare the clinical efficacy of Fu's subcutaneous acupuncture and western medication in the treatment of gastrointestinal dysfunction after knee surgery under general anesthesia.
- Trial name
- NCT07607249
- Testing
- Fu's Acupuncture group, Mosapride
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Zhenyu Zhang
Cytomegalovirus Infections
Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection
The trial will evaluate the safety and efficacy of letermovir antiviral treatment of active cytomegalovirus infection or cytomegalovirus disease in patients with infections that are refractory or resistant to available treatments…
- Trial name
- NCT03728426
- Testing
- Letermovir
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Amy C. Sherman, MD
Age-related Functional Decline, Mild Cognitive Impairment
Health Benefits of Nutraceutical Supplementation in Older Adults.
This study examines a multi-ingredient nutraceutical designed to support several areas of health in older adults, including muscle strength, cognitive function, immune response, and inflammation.
- Trial name
- NCT07534878
- Testing
- Powder containing whey isolate and herbal extracts (30g sachet)
- Where
- India
- Volunteers
- 23 people
- Sponsor
- GPLIFE HEALTHCARE PRIVATE LIMITED
Severe Malaria, Thrombocytopenia
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
- Trial name
- PLATFORM (NCT05711485)
- Testing
- Whole blood transfusion
- Where
- 2 sites in United States, Zambia
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Lupus Erythematosus, Scleroderma
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
The aim of this project is to start a biological and clinical collection of patients presenting systemic autoimmune disease. This collection will provide appropriate biological samples to identify new biomarkers and to be…
- Conditions
- Lupus Erythematosus, Scleroderma, Myositis, Vasculitis
- Trial name
- ESSAi (NCT05251415)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Pulmonary Hypertension, Diastolic Left Ventricular Dysfunction
Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
This is a single center, open-label trial designed to assess the safety and efficacy of ranolazine (Ranexa) in patients with pulmonary hypertension associated with left ventricular diastolic dysfunction.
- Trial name
- NCT02133352
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University
Hemiplegic Cerebral Palsy, Mirror Hands
Mirror Therapy in Children With Hemiparetic Cerebral Palsy
Cerebral palsy (CP) is a neurodevelopmental disorder that frequently impairs upper extremity motor control and hand function, resulting in limitations in daily activities.
- Conditions
- Hemiplegic Cerebral Palsy, Mirror Hands, Upper Extremity Dysfunction, Motor Activity
- Trial name
- NCT07734376
- Testing
- Mirror Therapy, Conventional Physiotherapy
- Volunteers
- 26 people
- Sponsor
- Marmara University
Postoperative Cognitive Dysfunction
Prognostic Factors Associated With Postoperative Cognitive Dysfunction After Surgery
A longitudinal observational study examining preoperative, intraoperative and postoperative factors associated with Postoperative Cognitive Dysfunction in patients older than the age of 50.
- Trial name
- POCDCOG (NCT03443440)
- Testing
- Neurocognitive Testing
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Milton S. Hershey Medical Center
Erectile Dysfunction, Peyronie' Disease
Management of Peyronie's Disease With Adipose Tissue Stem Cell
Erectile dysfunction is growing in prevalence all over the world and one of the most existing disease in old age patients There is many lines of treatment concerning the status of patient like psychosexual, medical, and surgical…
- Trial name
- NCT02414308
- Testing
- Adipose tissue stem cell injection
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Man Clinic for Andrology, Male Infertility and Sexual Dysfunction
Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site…
- Conditions
- Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain, Solid Neoplasm
- Trial name
- NCT02360215
- Testing
- Whole brain radiation therapy with hippocampal avoidance, Memantine, Whole brain radiation therapy
- Where
- 220 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- NRG Oncology
Chronic Granulomatous Disease
Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease
The overall goal of the study is to investigate the functional, biochemical, and gene expression effects of Interferon-gamma 1-b (IFN-γ) on the neutrophils of patients with Chronic Granulomatous Disease (CGD).
- Trial name
- NCT03548818
- Testing
- Interferon Gamma-1B
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Colorado, Denver
Abnormally Decreased Muscle Contraction
Abdominal Wall Evaluation in Low Back Pain
The purpose of this study was to evaluate feed-forward contraction of the transversus abdominis and thickness of the transversus abdominis, obliquus internus, and obliquus externus during calm and standardized respiration in low…
- Trial name
- NCT01488760
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Sexual Dysfunction
Female Sexual Function and Socioeconomic Status
In an urban gynecology practice serving patients with publicly and privately funded insurance, female sexual dysfunction was associated with low income, depression, urinary incontinence, and sexual inactivity.
- Trial name
- NCT02355860
- Testing
- assessment
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Brett Worly, MD
Obesity; Endocrine, Pituitary Dysfunction
NEUROENDOCRINE REGULATION OF BONE-FAT CROSSTALK IN OBESITY
To study the effect of neuroendocrine dysfunctions on bone health in obesity
- Conditions
- Obesity; Endocrine, Pituitary Dysfunction, Bone Health
- Trial name
- NCT06540820
- Testing
- Dexa or Biompedance analysis with clinical and biochemical evaluations
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Carotid Stenosis, Mild Cognitive Impairment
Dental Carotid Cognitive Study
Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive…
- Conditions
- Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
- Trial name
- NCT03755362
- Testing
- Standard Treatment, Intensive Treatment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Maryland, Baltimore
Acquired Brain Injury, Mild Cognitive Impairment
Impact of Intensive Computerized Cognitive Training
To investigate factors that predict cognitive enhancement following engagement in an intensive Computerized Cognitive Training Protocol.
- Conditions
- Acquired Brain Injury, Mild Cognitive Impairment, Mild Neurocognitive Disorder
- Trial name
- CCT (NCT06130735)
- Testing
- Cognitive Computerized Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Transthyretin (TTR) Amyloid Cardiomyopathy, Cardiac Amyloidosis
Liver and Coagulation Disorders in Cardiac Transthyretin Amyloidosis
Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive infiltrative cardiomyopathy caused by the deposition of misfolded transthyretin protein within the myocardium.
- Conditions
- Transthyretin (TTR) Amyloid Cardiomyopathy, Cardiac Amyloidosis, Cardiomyopathies, Wild-Type Transthyretin Cardiac Amyloidosis
- Trial name
- LICA2025 (NCT07766135)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Messina
Cerebral White Matter Lesions
MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and…
- Trial name
- NCT02276976
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei Wang
Insomnia, Mild Cognitive Impairment
Cognitive Training in Mild Cognitive Impairment
Older adults (60+ years of age) who meet criteria for mild cognitive impairment and insomnia will be randomly assigned to cognitive training or trivia training and will complete measures of anxiety, sleep, cognition (objective…
- Trial name
- TRAIN-MCI (NCT04899089)
- Testing
- Cognitive Training, Trivia Training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Missouri-Columbia
Mild Persistent Asthma
Response of FeNO, Small Airway Dysfunction and Lung Heterogeneity to 2-week Montelukast Treatment in Asthmatic Children.
This study aims to identify markers to prove rapid improvement of lung function, airway inflammation and bronchodilator response after 2-week LTRA administration.
- Trial name
- NCT01581710
- Volunteers
- 32 people
- Sponsor
- CHA University
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