Clinical trials: Pigment Deposition
Scar
Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color
The present study assesses if dissolvable (fast gut) or non-dissolvable (polypropylene) epidermal sutures produce better cosmetic results in terms of dyspigmentation and scarring in patients of skin of color.
- Trial name
- NCT05408117
- Testing
- 5-0 Polypropylene epidermal suture, 5-0 Fast gut epidermal suture
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Melissa Pugliano-Mauro
Age Related Maculopathy
The Role of Macular Pigment in Patients With Age-related Macular Degeneration
In the industrialised world age-related macular degeneration (ARMD) is the leading cause for legal blindness beyond the age of 50 years.
- Trial name
- NCT00494325
- Where
- Switzerland
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Macular Degeneration, Age-Related Macular Degeneration
The Focal Electro-Oculogram in Macular Disease
Background: Maculopathies are eye conditions that affect the center of the retina. Retina health depends on the retinal pigment epithelium (RPE), a layer behind the retina.
- Trial name
- NCT02225119
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration, Macular Degeneration
Treatment of Age-related Macular Degeneration by Fetal Retinal Pigment Epithelial Cells Transplantation
Early Phase I Study of the Safety and Preliminary Efficacy of Human Fetal Retinal Pigment Epithelial(fRPE) Cells Subretinal Transplantation in Age-Related Macular Degeneration(AMD) Patients
- Conditions
- Age Related Macular Degeneration, Macular Degeneration, AMD
- Trial name
- NCT02868424
- Testing
- fRPE cells
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Glaucoma, Primary Open Angle Glaucoma
Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma
Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
- Trial name
- TES-GPS (NCT06682962)
- Testing
- Transcorneal electrical stimulation (TES) with the OkuStim 2 System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Okuvision GmbH
Raman Spectroscopy
Raman Scattering Spectroscopy to Measure Macular Pigment
This study will evaluate the ease and reliability of Raman scattering spectroscopy, a new technique to measure the amount of the pigment lutein in the retina, the light-sensitive tissue lining the back of the eye.
- Trial name
- NCT00060580
- Testing
- Raman scattering spectroscopy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Sunscreening Agents
18750-Sun Protection Factor Assay
To evaluate the Sun Protection Factor (SPF) efficacy on human skin.
- Trial name
- SPF Assay (NCT02741466)
- Testing
- Coppertone (BAY987517)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Pigmentation Disorder
Fractional Laser as Treatment Option for Various Pigment Disorders
The purpose of this study is to determine whether the use of ablative fractional laser is effective in the treatment of Becker's nevus.
- Trial name
- fractional-2 (NCT01083498)
- Testing
- Ablative fractional laser therapy
- Volunteers
- 11 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Nonexudative Age-related Macular Degeneration
Directional Spread in Geographic Atrophy
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial countries. In the late stages of the disease, neovascular changes or the development of geographic atrophy (GA) may induce severe…
- Trial name
- DSGA (NCT02051998)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital, Bonn
Geographic Atrophy, Age-Related Macular Degeneration
OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration
Othera Pharmaceuticals' Othera (OT)-551 antioxidant eye drop has the potential for chronic treatment of the dry form of age-related macular degeneration.
- Conditions
- Geographic Atrophy, Age-Related Macular Degeneration, AMD
- Trial name
- NCT00306488
- Testing
- OT-551 antioxidant eye drop
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Myopic Choroidal Neovascularization, VEGF Aqueous Level
VEGF and PEDF in Patients With Myopic Choroidal Neovascularization
This was a prospective, case-control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVB.
- Conditions
- Myopic Choroidal Neovascularization, VEGF Aqueous Level, PEDF Aqueous Level
- Trial name
- NCT02175940
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi di Brescia
Skin Whitening
Role of Oral Glutathione in Skin Whitening
Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.
- Trial name
- NCT01016080
- Testing
- glutathione
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chulalongkorn University
Dry AMD With Macular Drusen
Repeatability and Reproducibility of Cirrus HD-OCT Macular Retinal Pigment Epithelium Elevation
The objective of this study is to determine the repeatability and reproducibility of the Cirrus HD-OCT measurements of drusen area and volume.
- Trial name
- NCT01890174
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Carl Zeiss Meditec, Inc.
Drusen Stage Macular Degeneration
Measurement and Analysis of Macular Retinal Pigment Epithelium (RPE) Elevations With Cirrus HD-OCT vs. Color Fundus Photography
The objective of this study is to compare the areas designated as elevated retinal pigment epithelium (RPE) by the Cirrus HD-OCT versus those designated as drusen on color fundus photographs (CFPs).
- Trial name
- NCT01272063
- Where
- 4 sites in United States
- Volunteers
- 91 people
- Sponsor
- Carl Zeiss Meditec, Inc.
Sunscreening Agents
Sun Protection Factor Assay (319/2016)
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- SPF Assay (NCT02995044)
- Testing
- BAY987521, SPF Control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bayer
Epiretinal Membrane, Dry Age Related Macular Degeneration
(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000
This study will measure how well PathFinder 1.0 detects retinal abnormalities on macular cube OCT B-scans by assessing its sensitivity and specificity.
- Conditions
- Epiretinal Membrane, Dry Age Related Macular Degeneration, Macular Abnormalities, Retina Disease
- Trial name
- NCT07680244
- Testing
- PathFinder 1.0 on CIRRUS HD-OCT
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec-Dublin CoCe
Age Related Macular Degeneration (AMD)
Production of iPSC Derived RPE Cells for Transplantation in AMD
No treatments exist for Age-related Macular Degeneration (AMD) when there is cell loss such as in late wet AMD or dry AMD. The differentiation of RPE cells from patient derived iPSC will offer valuable source of tissue for…
- Trial name
- NCT02464956
- Volunteers
- 3 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Choroidal Neovascularization, Retinal Pigment Epithelial Detachment
Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy
Study the effectiveness of the treatment detachment of retinal pigment epithelium secondary to polypoidal choroidal vasculopathy. Efficacy will be assessed by regression of polyp area after twelve months, compared to baseline.
- Trial name
- NCT01666236
- Testing
- Triple Therapy
- Where
- Brazil
- Sponsor
- Federal University of São Paulo
Presence of Retinal Fluid, Changes in Macular Pigment Optical Density
Aflibercept 8 mg for nAMD: Early Anatomical and Functional Changes
Neovascular age-related macular degeneration (nAMD) is one of the main causes of irreversible vision loss in older people worldwide.
- Trial name
- NCT07074054
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Glaucoma
AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure
The purpose of this study was to assess the safety and efficacy of switching to Azarga from prior pharmacotherapy in patients with open-angle glaucoma.
- Trial name
- NCT01484951
- Testing
- Brinzolamide 1% and timolol 0.5% fixed combination eye drops
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Alcon Research