Clinical trials: Pigment Disorders
Dermatologic Disease, Vitiligo
Vitiligo Registry for Adults and Children in the UK
Vitiligo is the most common depigmentation disorder affecting around 1% of the population worldwide. Fifty two percent of patients develop vitiligo before the age of 20 and around 80% develop vitiligo before the age of 30 years…
- Trial name
- VIRTUAL-UK (NCT06218082)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Pigmentation Disorder
Fractional Laser as Treatment Option for Various Pigment Disorders (Fractional-3)
The purpose of this study is to determine whether the use of non-ablative fractional laser is safe and effective in the treatment of melasma.
- Trial name
- NCT01085279
- Testing
- Fraxel Restore, Solta Medical Inc. (Non-ablative fractional laser), Modified Kligman's formula (Triple topical therapy)
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Netherlands Institute for Pigment Disorders
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Xeroderma Pigmentosum
Xeroderma Pigmentosum Patient Experiences
Xeroderma Pigmentosum (XP) is a rare skin condition that causes extreme sensitivity to the sun and an increased incidence of skin cancers.
- Trial name
- NCT01123694
- Testing
- Survey Study
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Henry Ford Health System
Obstructive Sleep Apnea, Vasovagal Syncope
Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms.
The goal of this prospective cohort study is to study patients referred for sleep study by in-lab polysomnography in the Jordan University Hospital and the Jordan Hospital or with an at-home sleep study kit.
- Conditions
- Obstructive Sleep Apnea, Vasovagal Syncope, Smoking, Acanthosis Nigricans
- Trial name
- VasOSA (NCT06331819)
- Testing
- In-lab polysomnography, Continuous positive airway pressure, Home sleep study device
- Where
- Jordan
- Volunteers
- 200 people
- Sponsor
- Jordan Collaborating Cardiology Group
Hyperpigmentation; Melanin, Laser-Induced Hyperpigmentation
Laser-Assisted Gingival Depigmentation
This randomized clinical trial evaluated the recurrence rates of physiological gingival pigments during 24 months follow-up and the patient perceptions after the ablative depigmentation using two laser wavelengths; Diode 940 nm…
- Trial name
- NCT04680806
- Testing
- Er,Cr:YSGG laser 2780 nm, Diode laser 940 nm
- Where
- Qatar
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academy of Laser Dentistry - Gulf Laser Chapter
Acanthosis Nigricans
Study of the Effect of Fractional co2 Laser Versus Q Switched:NdYAG Laser in the Treatment of Acanthosis Nigricans
This prospective randomized comparative split study will be conducted at the outpatient clinic, Dermatology department, Faculty of Medicine, Cairo University and will include 20 patients with acanthosis nigricans in otherwise…
- Trial name
- NCT04893304
- Testing
- co2 laser
- Volunteers
- 20 people
- Sponsor
- Cairo University
Vitiligo
Efficacy and Safety of Apremilast in Combination with NBUVB and NBUVB Alone in Vitiligo Patients
Patients of non-segmental vitiligo, fulfilling the inclusion criteria will be selected from the OPD, dermatology department. It\'s an interventional study where Group A patient will be given NBUVB and Tab Apremilast 30 mg…
- Trial name
- NCT06593197
- Testing
- Apremilast with NB-UVB, NB-UVB
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Dow University of Health Sciences
Melasma
Trichloroacetic Acid (TCA) Combined With Microdermabrasion in Treatment of Melasma
1. To detect the efficacy and safety of combined TCA and MDA in treating melasma. 2. To compare the efficacy and safety of using different TCA concentrations (15% \& 20%) alone and in combination with MDA in treatment of melasma.
- Trial name
- NCT04823520
- Testing
- TCA
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pulse Oximetry, Disparities
Beyond Race: Objectively Assessed Skin Color and Its Association With Pulse Oximeter Bias in Critically Ill Infants
The overall objective of this proposal is to quantify the bias in pulse oximeter reported oxygen saturation (SpO2) by evaluating its measures compared to the gold standard blood gas measured arterial oxygen saturation (SaO2)…
- Conditions
- Pulse Oximetry, Disparities, Infants
- Trial name
- NCT05994417
- Volunteers
- 200 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Vitiligo
Study of the Efficacy and Safety of Etanercept in Adults With Vitiligo
The purpose of this study is to investigate the efficacy and safety of etanercept in adults with vitiligo.
- Trial name
- NCT00134368
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Melasma
Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
This is a prospective, multi-center, split-face, controlled clinical trial that aims to investigate the efficacy and safety of picosecond, neodymium-doped yttrium aluminum garnet laser laser therapy on patients with melasma…
- Trial name
- NCT03040089
- Testing
- PICO+4, Neoquine Cream 2%
- Volunteers
- 40 people
- Sponsor
- CynosureLutronic
SCAR
Bleomycin Infusion (MMP®) to Repigment Achromic Scars
This intervention, called MMP®, is a procedure whereby drugs are injected through tattoo machines.
- Trial name
- MMP® (NCT04046679)
- Testing
- Bleomycin, Saline Solution
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Clinica Dermatologica Arbache ltda
Vitiligo, Effect of Drug
Role of Tofacitinib in Vitiligo Patients
Standard treatment for vitiligo often has unsatisfactory outcomes. With a new understanding of pathogenesis, novel drugs have been introduced which have shown to be effective in small-scale studies.
- Trial name
- ETV (NCT05293119)
- Testing
- JAK-2 inhibitor, Topical corticosteroid
- Volunteers
- 80 people
- Sponsor
- Pi Research Consultancy Center, Bangladesh
Glaucoma, Open-Angle
European Nutrition in Glaucoma Management Trial
European Nutrition in Glaucoma Management (ENIGMA) trial will evaluate the effect of 18-month supplementation with lutein, zeaxanthin and meso-zeaxanthin on macular pigment (MP) levels, vision, cognition and serum biomarkers of…
- Trial name
- ENIGMA (NCT04460365)
- Testing
- 10 mg Lutein, 2 mg zeaxanthin, 10 mg meso-zeaxanthin
- Where
- Ireland
- Volunteers
- 64 people
- Sponsor
- Centre for Eye Research Ireland
Inherited Retinal Dystrophy Due to RPE65 Mutations, Leber Congenital Amaurosis
Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis
The study is a Phase 3, open-label, randomized controlled trial of gene therapy intervention by subretinal administration of AAV2-hRPE65v2 (voretigene neparvovec-rzyl).
- Trial name
- NCT00999609
- Testing
- AAV2-hRPE65v2,voretigene neparvovec-rzyl
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Spark Therapeutics, Inc.
Melasma, Melasma (Facial Melasma)
Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma
The data will be collected after the permission of the ethical committee of hospital. Following the enrollment, patients will be selected by lottery in the two equal groups.
- Trial name
- NCT07732192
- Testing
- Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone
- Volunteers
- 128 people
- Sponsor
- Combined Military Hospital Abbottabad
Vitiligo
Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment
- Trial name
- STRAVI (NCT05927272)
- Testing
- SKIN SAMPLES, BLOOD SAMPLES, narrowband UVB
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Vitiligo
Tyrosine Vs Tacrolimus With NB-UVB in Vitiligo
The goal of this clinical trial is to learn if adding topical tacrolimus or topical tyrosine to narrowband UVB phototherapy works to treat vitiligo in adults. It will also learn about the safety of both combinations.
- Trial name
- NCT07532330
- Testing
- Narrowband UVB Phototherapy, Topical Tacrolimus 0.1% ointment, Topical Tyrosine 2% cream
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Minia University
CHD - Congenital Heart Disease, Single Ventricle Heart Disease
PRecision Integrated Saturation Monitor
The purpose of this study is to find out if an abdominal pulse oximeter device is as accurate as a conventional fingertip pulse oximeter in pediatric patients.
- Trial name
- PRISM (NCT07686341)
- Testing
- vital sign monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital