Clinical trials: Piperacillin-tazobactam
Critical Illness, Antibiotic Toxicity
Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients
Although alternative dosing strategies can improve antimicrobial exposure in critically ill patients, the high PK variability in this population means that some may still receive sub-optimal antibiotic exposure leading to…
- Conditions
- Critical Illness, Antibiotic Toxicity, Sepsis, Septic Shock
- Trial name
- DOSATB (NCT04530045)
- Testing
- dosage of concentration of piperacillin and cefepim
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- Central Hospital, Nancy, France
Febrile Neutropenia
Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients
This study evaluates the administration of beta-lactam antibiotics in extended infusion in hematological patients with febrile neutropenia after 5 days of treatment.
- Trial name
- BEATLE (NCT04233996)
- Testing
- Piperacillin-Tazobactam 4 g-0.5 g, Cefepime 2000 mg, Meropenem 1000 mg
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Universitari de Bellvitge
Nosocomial Pneumonia
Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial Pneumonia
1. To observe clinical and bacteriologic responses of different regimens of piperacillin/tazobactam (4.5g q6h, prolonged or intermittent infusion) for treatment of nosocomial pneumonia. 2.
- Trial name
- NCT01796717
- Testing
- C Group, E Group
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hematologic Neoplasms, Neutropenia
Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients
Patients with hematological malignancies receive highly myelotoxic chemotherapy regimens that cause periods of severe myelosuppression, which places them at high risk of developing bacteremia.
- Trial name
- NCT06422533
- Testing
- Ceftolozane/tazobactam, Piperacillin/tazobactam
- Where
- Mexico
- Volunteers
- 226 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital
Urinary Tract Infection Symptomatic, Acute Pyelonephritis
Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections
The purpose of the study is to demonstrate the safety and efficacy of ZTI-01 (IV fosfomycin) as non-inferior to piperacillin/tazobactam in overall success (clinical cure and microbiologic eradication) for the treatment of…
- Conditions
- Urinary Tract Infection Symptomatic, Acute Pyelonephritis, Urinary Tract Infection Complicated
- Trial name
- ZEUS (NCT02753946)
- Testing
- ZTI-01, Piperacillin-tazobactam
- Where
- 68 sites in United States, Belarus and 14 more
- Volunteers
- 465 people
- Sponsor
- Nabriva Therapeutics AG
Bacterial Pneumonia
Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014)
This study aims to compare treatment with a fixed-dose combination (FDC) of imipenem/relebactam/cilastatin (IMI/REL) with a FDC of piperacillin/tazobactam (PIP/TAZ) in participants with hospital-acquired or ventilator-associated…
- Trial name
- RESTORE-IMI 2 (NCT02493764)
- Testing
- Imipenem, Relebactam, Cilastatin
- Volunteers
- 537 people
- Sponsor
- Merck Sharp & Dohme LLC
Critical Illness
Safety and Efficacy of Vancomycin Plus Beta-lactams
The combination of vancomycin and piperacillin-tazobactam has been associated with an increased risk of acute kidney injury (AKI) in non-critically ill patient populations, but it is still unknown if this association exists in…
- Trial name
- SEVPB (NCT03776409)
- Testing
- vancomycin plus piperacillin/tazobactam, vancomycin plus other beta-lactams
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Septic Shock, Sepsis
Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU
The pharmacokinetics of antimicrobials is profoundly modified in Intensive care unit (ICU) patients. To adapt the treatment, it is recommended to measure blood levels of antibiotics.
- Conditions
- Septic Shock, Sepsis, Sepsis Syndrome
- Trial name
- OPTIMA (NCT03990467)
- Testing
- Plasma dosage of amikacin, piperacillin and tazobactam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Bacterial Infections
Study Evaluating Zosyn in Hospitalized Patients With Intra-abdominal Infection
A Phase IV, multicenter study of hospitalized patients with complicated intra-abdominal infection.
- Trial name
- NCT00044928
- Testing
- Piperacillin/Tazobactam
- Volunteers
- 262 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Septic Shock, Acute Renal Failure
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal…
- Trial name
- NCT00816790
- Testing
- Piperacillin/Tazobactam
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Fraser Health
Cardiac Dysfunction
Population Pharmacokinetics of Teicoplanin, Levofloxacin, Piperacillin/Tazobactam, Meropenem, Vancomycin, Remifentanil, Cefepime, Cefpirome, Sufentanil, Midazolam, Clopidogrel, Ticagrelor, Prasugrel During Veno-arterial Extracorporeal Membrane Oxygenation (VA ECMO)
Extracorporeal membrane oxygenation (ECMO) is the device which increases the supply of oxygen to the body tissues in vitro and to assist in heart and lung function.
- Trial name
- NCT02581280
- Testing
- Residual blood
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Pneumonia
Study to Demonstrate the Clinical Efficacy of Levofloxacin in the Treatment of Pneumonia
Primary Objective: The primary objective of the study is to demonstrate the non-inferiority in clinical efficacy at the test of cure (TOC) visit planned 5-7 days after treatment completion of levofloxacin 750 mg once daily (od)…
- Trial name
- NCT00253955
- Testing
- Levofloxacin, Piperacillin/Tazobactam
- Where
- 17 sites in Austria, Belgium and 15 more
- Volunteers
- 460 people
- Sponsor
- Sanofi
Abdominal Infection
Effect Study of Tigecycline to Treat Severe Sepsis and Septic Shock
Selection of tigecycline in severe sepsis and septic shock patients in empirical antibiotic therapy (Hai Zheng Energy Star ®) combined with piperacillin / tazobactam (tazocin ®) scheme, compared with the classical scheme…
- Trial name
- Tigecycline (NCT02191475)
- Testing
- glycopeptide plus carbapenem, Haizheng Li Xing ® plus tazocin ®
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Urinary Tract Infections
Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections
Multi-center, randomized, double-blind, non-inferiority study of cefepime 2 g/AAI101 500 mg combination compared to piperacillin 4 g/tazobactam 500 mg in a population of adult patients with cUTI or AP.
- Trial name
- NCT03687255
- Testing
- cefepime/AAI101 combination, Piperacillin/tazobactam
- Where
- 24 sites in United States, Argentina and 17 more
- Volunteers
- 1,043 people
- Sponsor
- Allecra
Urinary Infections
Study Evaluating Piperacillin/Tazobactam in Complicated Urinary Infections.
The primary objective is to study the efficacy of piperacillin/tazobactam in patients with complicated urinary tract infections
- Trial name
- NCT00195286
- Testing
- piperacillin/tazobactam
- Where
- 27 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Febrile, Neutropenia
Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia
Neutropenia is very common in patients received hematopoietic stem cell transplantation, with median duration of about 14 days. In 2010 update, IDSA recommended Piperacillin/tazobactam as first-line mono-therapy for febrile…
- Conditions
- Febrile, Neutropenia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT01714570
- Testing
- Piperacillin-tazobactam combination product, Imipenem
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Chinese PLA General Hospital
Foot Infections in Diabetic Patients
Comparative Study of Ertapenem Versus Another Antibiotic in the Treatment of Diabetic Foot Infections in Adults (0826-034)
This study will compare the efficacy, safety and tolerability of intravenous ertapenem versus another intravenous antibiotic in the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT00229112
- Testing
- MK0826, ertapenem sodium / Duration of Treatment - 24 weeks, Comparator: Piperacillin/Tazobactam / Duration of Treatment - 24 weeks
- Volunteers
- 400 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Respiratory Failure With Hypoxia
PK of Piperacillin/Tazobactam in Adults Undergoing ECMO
This study is designed to provide preliminary data to determine if concentrations of piperacillin/tazobactam change in patients with severe respiratory failure receiving extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT03467854
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University