Clinical trials: Pituitary Cancer
Uterine Leiomyoma
Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy
The purpose of this study is to compare the effect of the concentration of vasopressin, which is used as a method for reducing blood loss in robot-assisted laparoscopic myomectomy.
- Trial name
- VALENTINE (NCT04874246)
- Testing
- Vasopressin
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Seoul National University Hospital
Pituitary Adenoma
Outcome Analysis of Endoscopic Resection of Pituitary Adenomas
The goal of this prospective study is to learn about the operative outcomes in patients with pituitary adenoma who receive endoscopic resection.
- Trial name
- NCT06156020
- Testing
- Endoscopic endonasal surgery
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Cheng-Kung University Hospital
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Cushing Syndrome, Hypercortisolism
Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients
This cross-sectional, single-center study will assess the microvascular function using a nailfold video-capillaroscopy in patients with endogenous Cushing syndrome.
- Trial name
- NCT04433819
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cushing's Syndrome
Study to Evaluate CORT125134 in Participants With Cushing's Syndrome
Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated endogenous or exogenous sources of cortisol.
- Trial name
- NCT02804750
- Testing
- CORT125134
- Where
- 25 sites in United States, Hungary and 3 more
- Volunteers
- 35 people
- Sponsor
- Corcept Therapeutics
Pituitary Tumor, Endoscopic Surgery
The Impact of Endoscopic Pituitary Surgery on Nasal Function
The aim of this study is to determine the impact of endoscopic transsphenoidal pituitary surgery on nasal function using a numerical simulation and to compare the difference between two kinds of transsphenoidal approachese(single…
- Conditions
- Pituitary Tumor, Endoscopic Surgery, Quality of Life, Function of Nose
- Trial name
- NCT04018963
- Testing
- Single nostril approach endoscopic transsphenoidal pituitary surgery, Bilateral nostril approach endoscopic transsphenoidal pituitary surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhebao Wu
Pituitary Tumors
Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.
DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all…
- Trial name
- NCT05634655
- Testing
- no interventions between two groups
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis
Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis, Gastrointestinal Carcinoid Tumor, Head and Neck Cancer
- Trial name
- NCT00002947
- Testing
- indium In 111 pentetreotide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University
Non-Functional Pituitary Adenoma, Pituitary Tumor, Nonfunctioning
TBR-760 in Adult Patients With Non-Functioning Pituitary Adenomas
This is a randomized, double-blind, placebo-controlled study to assess the safety, tolerability, efficacy, PK, and PD of the chimeric dopamine-somatostatin receptor agonist, TBR-760, in adult patients with NFPA over 52 weeks.
- Trial name
- NCT04335357
- Testing
- TBR-760
- Volunteers
- 150 people
- Sponsor
- Tiburio Therapeutics
Pituitary Adenoma
Prediction of Sphenoid Septation in MRI Compared With CT and Intraoperative Findings During Endoscopic Pituitary Adenoma Surgery
To investigate whether MRI is able to predict the exact anatomy and topography of the sphenoid sinus and its relationship to the sellar, parasellar und paraclinoid region and where CT yields more detailed information for the…
- Trial name
- Scope (NCT03624114)
- Testing
- comparison of data from MRI with data from CT compared with intraoperative data from endoscopic pituitary adenoma surgery
- Where
- 2 sites in Malaysia, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Pituitary Adenoma
Heart Rate Variability (HRV) in Pituitary Adenoma
Several studies have been reported that heart rate is known to be associated with prognosis in chronic diseases and acute diseases.
- Trial name
- NCT03164148
- Testing
- T-REX TRI00A
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Polycystic Ovary Syndrome, Endometriosis
Mathematical Model for the Human Menstrual Cycle, Endocrinological Diseases and Fertility Treatment-PAEON
Development of a bio-mathematical model of the human female cycle
- Conditions
- Polycystic Ovary Syndrome, Endometriosis, Hyperprolactinemia
- Trial name
- PAEON (NCT02098668)
- Testing
- Fertility treatment
- Where
- Switzerland
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor
China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm
The goal of this observational study is to learn about the treatment strategies for tumor in sellar region with unruptured intracranial aneurysms in the Chinese population.
- Conditions
- Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor, Craniopharyngioma, Meningioma
- Trial name
- ChTTSRUIA (NCT07809178)
- Testing
- Tumor resection followed by aneurysm treatment, Aneurysm treatment followed by tumor resection, Observation
- Where
- China
- Volunteers
- 608 people
- Sponsor
- Cheng sen
Pituitary Adenoma
Transnasal Endoscopic Pituitary Surgery - the Effect of Posterior Nasal Septum Resection on Nasal Functions
The aim of the project is to compare the effect of different extent of resection of the posterior part of the septum on the postoperative nasal functions.
- Trial name
- NCT04782596
- Testing
- Posterium nasal septum resection
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Hyperprolactinemia, Prolactinoma
Treatment of Hyperprolactinemia With the Non-ergoline Dopamine Agonist Ropinirole
The purpose of this study is to evaluate the use of the non-ergoline dopamine agonist ropinirole for the treatment of hyperprolactinemia in patients with idiopathic hyperprolactinemia and prolactinomas.
- Trial name
- NCT03038308
- Testing
- Ropinirole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Pituitary, Pain, Postoperative
Postop Pain Management in Pituitary Tumour Patients
To assess the benefit of using an additional nerve block during minimally invasive pituitary surgery, to improve pain management after surgery.
- Trial name
- POPPY (NCT06353529)
- Testing
- Bupivacaine-Epinephrine 0.5%-1:200,000 Injectable Solution
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Hamilton Health Sciences Corporation
Pituitary Disease, Pituitary Incidentaloma
Seoul National University Pituitary Disease Cohort Study
The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning…
- Conditions
- Pituitary Disease, Pituitary Incidentaloma, Acromegaly, Central Diabetes Insipidus
- Trial name
- SNU-PIT (NCT03474601)
- Testing
- Dynamic hormone study and Magnetic resonance imaging
- Where
- South Korea
- Volunteers
- 1,600 people
- Sponsor
- Seoul National University Hospital
Misoprostol Allergy, Oxytocin Allergy
Methods Decreasing Bleeding in Open Myomectomy
Uterine leiomyomas (fibroids or myomas) are benign, smooth muscle tumors of the human uterus. Most myomas are asymptomatic (symptomless) and are discovered incidentally during a routine pelvic examination or imaging studies and…
- Conditions
- Misoprostol Allergy, Oxytocin Allergy, Tranexamic Acid Allergy, Ethamsylate Allergy
- Trial name
- NCT05806307
- Testing
- Misoprostol, Tourniquet, Carbetocin
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Colorectal Cancer, Lung Cancer
The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
The purpose of this research is to determine whether the drug, Bevacizumab (a monoclonal anti VEGF-A antibody), which is approved to treat patients with metastatic colon cancer induces hyperprolactinemia (increased prolactin…
- Conditions
- Colorectal Cancer, Lung Cancer, Breast Cancer, Glioblastoma
- Trial name
- NCT00973557
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center