Clinical trials: Pituitary Cancer
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Headache, Pituitary Adenoma
Prediction Model for Postoperative Headache After Transsphenoidal Pituitary Surgery
Primary Objective: This observational study aims to construct a predictive model for short-term headache following endonasal pituitary adenoma surgery and to identify risk factors associated with postoperative headache after…
- Conditions
- Headache, Pituitary Adenoma, Endonasal Surgery, Predictive Model
- Trial name
- NCT07446036
- Testing
- Transsphenoidal Pituitary Surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Brain Tumor, Recurrent
Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas
This study will be aimed at investigating the effectiveness of a treatment for brain tumors called Photodynamic Therapy, or PDT.
- Trial name
- NCT01966809
- Testing
- Photofrin photodynamic therapy.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Harry T Whelan, MD
Pituitary Tumors
Identification of GENEtic Markers of Aggressiveness and Malignancy by Array Comparative Genomic Hybrization Analysis (CGH)
Recent studies estimate that the prevalence of pituitary adenomas is approximately 1/1500 persons. Pituitary tumours are usually considered as benign.
- Trial name
- PITUIGENE (NCT01903967)
- Where
- France
- Volunteers
- 213 people
- Sponsor
- Hospices Civils de Lyon
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Kisspeptin Administration in the Adult
The goal of this study is to learn about the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that causes the release of other hormones, including gonadotropin-releasing hormone…
- Conditions
- Hypogonadotropic Hypogonadism, Kallmann Syndrome, GnRH Deficiency, PCOS
- Trial name
- NCT00914823
- Testing
- kisspeptin 112-121, GnRH
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pituitary Neoplasms, Adenoma
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas
Due to lack of hormone overproduction in non-functioning pituitary adenomas (NFPAs), only the symptomatic adenomas or large adenomas with proven growth and risk for symptoms in near future will undergo pituitary surgery.
- Trial name
- NCT02288962
- Testing
- cabergoline
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 60 people
- Sponsor
- St. Olavs Hospital
Brain and Central Nervous System Tumors
Temozolomide in Treating Patients With Invasive Pituitary Tumors
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00601289
- Testing
- temozolomide, DNA methylation analysis, microarray analysis
- Sponsor
- Jonsson Comprehensive Cancer Center
Panhypopituitarism, Craniopharyngioma
The Effect of GLP-1 Agonist in Patients With Hypothalamic Obesity: Prospective, Pilot Study
GLP-1 analogs are used as agents in the existing treatment of obesity. However, there are lack of previous reports on the effectiveness and role of GLP-1 analogs in the development of obesity traits in patients with functionally…
- Conditions
- Panhypopituitarism, Craniopharyngioma, Hypothalamic Obesity
- Trial name
- NCT06217848
- Testing
- Saxenda
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Acromegaly
A Prospective Study of Outcome After Therapy for Acromegaly
The purpose of this study is to evaluate hormone values and other markers of disease activity in a cohort of patients with acromegaly at the time of diagnosis and then prospectively after surgical or other treatment.
- Trial name
- NCT01809808
- Testing
- Surgery for acromegaly, Medications for acromegaly, Total body magnetic resonance imaging
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prolactin-Producing Pituitary Tumor
A Study of Pasireotide in People With Prolactinoma
The researchers are doing this study to find out whether pasireotide is an effective treatment for people with prolactinoma who cannot receive dopamine agonist therapy.
- Trial name
- NCT06295952
- Testing
- Pasireotide, SF-36 and HADS
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pituitary Tumor, Visual Fields Hemianopsia
Perimetry Based on Eye-movements in Patients With (Supra)Sellar Tumors
The purpose of this study is to assess wether the SONDA visual field test is suitable for patients with a supra sellar tumour.
- Trial name
- NCT06266949
- Testing
- SONDA
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Pituitary Adenoma
Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland.
- Trial name
- NCT02709863
- Testing
- Sevoflurane, Desflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Hypopituitarism, Radiotherapy-Induced Hypopituitarism
Improving Survivorship and Health-related Quality of Life in Patients With Primary Brain Tumours
Background: Approximately 480 primary, non-pituitary, brain tumours were diagnosed in Ireland each year between 1994 and 2013. Recent developments in treatment have greatly improved survival for younger patients in the 15-54 age…
- Conditions
- Hypopituitarism, Radiotherapy-Induced Hypopituitarism, Brain Tumor
- Trial name
- NCT06014398
- Testing
- Dynamic testing of Pituitary Function
- Where
- 2 sites in Ireland
- Volunteers
- 50 people
- Sponsor
- Royal College of Surgeons, Ireland
Acromegaly, Neuroendocrine Tumours
Somatuline Predictive Factors in Acromegaly and NET
The aim of the study is to identify predictive factors for the response to Lanreotide treatment in Acromegaly as well as in Neuroendocrine Tumours.
- Trial name
- SOPRANo (NCT01840449)
- Testing
- Somatuline Autogel® 60, 90 or 120 mg
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 156 people
- Sponsor
- Ipsen