Clinical trials: Pituitary Cancer
Pituitary Tumor, Visual Fields Hemianopsia
Perimetry Based on Eye-movements in Patients With (Supra)Sellar Tumors
The purpose of this study is to assess wether the SONDA visual field test is suitable for patients with a supra sellar tumour.
- Trial name
- NCT06266949
- Testing
- SONDA
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Macroprolactinoma
Efficacy of Rapid Escalation of Cabergoline in Comparison to Conventional Dosing in Prolactin Secreting Macroadenomas.
To study the effects of rapid escalation of Cabergoline in comparison to conventional dosing in macroprolactinomas. Rapid escalation of cabergoline may help in earlier normalization of prolactin and shrinkage of tumor mass, and…
- Trial name
- NCT01143584
- Testing
- Cabergoline
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Prolactinoma, Pituitary Tumor
The PROMISE Survey
The PROMISE Survey was developed to systematically assess the real-world experiences, treatment preferences, side effects, and outcomes from both patients and physicians dealing with prolactinomas.
- Trial name
- NCT06936813
- Where
- Switzerland
- Volunteers
- 530 people
- Sponsor
- University Hospital, Basel, Switzerland
Pituitary Tumor
Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach
Transnasal transsphenoidal (TNTS) resection of pituitary tumors involves wide fluctuation in hemodynamic parameter and causes hypertension and tachycardia due to intense noxious stimuli during various stages of surgery.
- Trial name
- NCT03132259
- Testing
- high dose dexmedethomidine, low dose dexmedethomidine
- Where
- Thailand
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Polycystic Ovary Syndrome, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
Subclinical Hypothyroidism and Normogonadotropic Anovulation
Thyroid hormones (TH) can modify the functioning of the hypothalamic-pituitary-ovarian axis, affecting the functions of granulosa cells and the development and apoptosis of preantral follicles.
- Trial name
- NCT05782725
- Testing
- Comparison of laboratory test results in women in the 4 study arms
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
- Trial name
- NCT06523582
- Where
- 3 sites in Mexico
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Postoperative Pain, Acute
The Effect of Local Anesthesia on Postopanalgesia in Patients Using Head Holder
Aim:The head holder used in neurosurgery operations causes pain in patients both peroperatively and postoperatively.Severe pain-related hemodynamic changes are seen in these participants.In our study, the investigators compared…
- Trial name
- NCT07629713
- Testing
- lidocaine was administered subcutaneously at 0.5% concentration., lidocaine was administered subcutaneously at 1% concentration.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Kocaeli University
Pituitary Tumor
NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm
Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory…
- Trial name
- NET-TIME (NCT07594262)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
McCune Albright Syndrome, Polyostotic Fibrous Dysplasia
A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome
This study will examine the effect of pegvisomant on growth hormone excess in patients with McCune-Albright syndrome (MAS). Patients with this disease have polyostotic fibrous dysplasia-a condition in which areas of normal bone…
- Trial name
- NCT00017927
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Long Term, Hypopituitarism
Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas
This study aims to assess long-term outcomes of hypopituitarism following gamma knife radiosurgery (GKRS) for pituitary adenomas.
- Conditions
- Long Term, Hypopituitarism, Gamma Knife Radiosurgery, Pituitary Adenomas
- Trial name
- NCT07015645
- Testing
- Gamma Knife Radiosurgery
- Where
- Egypt
- Volunteers
- 137 people
- Sponsor
- Al-Azhar University
Pituitary Adenoma
Copeptin as a Diagnostic Marker in the Management of Neurosurgical Patients With Disturbance of Water Homeostasis
Water imbalance and consecutive electrolyte disturbances are common in the postoperative course of neurosurgical patients after pituitary surgery.
- Trial name
- NCT01465672
- Where
- 2 sites in Switzerland
- Volunteers
- 125 people
- Sponsor
- University Hospital, Basel, Switzerland
Cushing Syndrome, Cushing Disease
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome
A Phase 1b/2a, first-in-disease, open-label, multiple-ascending dose exploratory study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamic biomarker responses associated with CRN04894 (an…
- Conditions
- Cushing Syndrome, Cushing Disease, Ectopic ACTH Syndrome
- Trial name
- NCT05804669
- Testing
- atumelnant
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Crinetics Pharmaceuticals Inc.
Colorectal Neoplasms
Acupuncture to Reduce Symptoms of Advanced Colorectal Cancer
This study investigates the effect of acupuncture in reducing symptom distress in adults with advanced colon cancer.
- Trial name
- NCT00034034
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pituitary Adenoma, Neuroendocrine Tumors
Predictive Value of Serum and Tissue Molecular Markers and Imaging Features in the Invasiveness and Prognosis of Pituitary Neuroendocrine Tumors
As the clinical manifestations of pituitary neuroendocrine tumors vary greatly, 2.7-15% of them are resistant to conventional treatments such as surgery, drug therapy and radiotherapy, and often relapse or regrow in the early…
- Trial name
- NCT06015802
- Testing
- diagnosed and treated reasonably according to the clinical guidelines and clinical pathways
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Growth Hormone Deficiency
Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women
The purpose of the study is to evaluate the effects of growth hormone replacement on women with growth hormone deficiency. Growth hormone deficiency means the body no longer produces growth hormone due to a tumor or some kind of…
- Trial name
- NCT00136032
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Massachusetts General Hospital
Cushing Syndrome
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
This is a Phase 3, double-blind, placebo-controlled, randomized-withdrawal study to assess the efficacy, safety and pharmacokinetics (PK) of relacorilant in patients with endogenous Cushing syndrome and concurrent type 2 diabetes…
- Trial name
- GRACE (NCT03697109)
- Testing
- Relacorilant
- Where
- 64 sites in United States, Austria and 9 more
- Volunteers
- 152 people
- Sponsor
- Corcept Therapeutics
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
This observational, prospective, non-interventional study will include cancer patients who need a treatment for hyponatraemia secondary to SIADH.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Cancer
- Trial name
- ASSERT (NCT02573077)
- Where
- 20 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Craniopharyngioma
Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma
With the preliminary anatomical and histological study, the membranous structures of the sellar region was considered to be closely related with the growth pattern of Craniopharyngiomas(CP).
- Trial name
- NCT00949156
- Testing
- Different surgical approach and techniques being used to treat three subtype of CP
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Southern Medical University, China
Headache, Pituitary Tumor
The TMS Treatment for Postoperative Headache in GH Tumor
Headache is a very common main complaint of patients with GH pituitary tumor, which has seriously affected the normal work and life of patients.
- Conditions
- Headache, Pituitary Tumor, Acromegaly
- Trial name
- NCT04529356
- Testing
- Transcranial magnetic stimulation, Acetaminophen
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital