Clinical trials: Pituitary Cancer
Anovulation, Oligo-ovulation
Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women
This is an open-label, parallel-group, randomized, multicenter Phase III trial to compare the efficacy and safety of a single 250 microgram (mcg) subcutaneous dose of MSJ-0011 to a single 5,000 international units (IU)…
- Conditions
- Anovulation, Oligo-ovulation, Hypothalamic-pituitary Dysfunction, Polycystic Ovarian Syndrome
- Trial name
- NCT01653743
- Testing
- MSJ-0011, urinary hCG (u-hCG), Follitropin alpha
- Where
- 6 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pituitary Tumor
Characterization of Receptors in Non-functioning Pituitary Macroadenomas
Characterization of receptors present in non-functioning pituitary macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) would assist with targeted medical therapy based on the information obtained by…
- Trial name
- NCT00852501
- Testing
- To perform RT-PCR on the tissue obtained during surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cook County Health
Neuroendocrine Tumors, Insulinoma
DOTATOC PET/CT for Imaging NET Patients
Neuroendocrine tumours (NETs) are generally slow growing, but some can be aggressive and resistant to treatment. Compared to healthy cells, the surface of these tumor cells has a greater number of special molecules called…
- Conditions
- Neuroendocrine Tumors, Insulinoma, Gastrinoma, Glucagonoma
- Trial name
- NCT03583528
- Testing
- 68Ga-DOTATOC PET/CT, 18F-FDG PET/CT
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- British Columbia Cancer Agency
Prolactinomas
Cardiac Valve Complications in Prolactinomas Treated With Cabergoline
Dopamine agonists are first-line agents for the treatment of prolactinomas (1) and Parkinson's disease (2). There is evidence supporting a causal relationship between the occurrence of drug-induced "restrictive" valvular heart…
- Trial name
- ValveCab (NCT00460616)
- Testing
- Cabergoline
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Pituitary Tumor
Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor
A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery.
- Trial name
- NCT02813044
- Testing
- total intravenous anesthesia (TIVA), inhalation anesthesia group
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Resistance, Disease, Prolactinoma
Cabergoline Combined Hydroxychloroquine/Chloroquine to Treat Resistant Prolactinomas
The purpose of this study is to preliminarily evaluate the safety and efficacy of cabergoline combined hydroxychloroquine/chloroquine(HCQ/CQ) therapy for cabergoline-Resistant Prolactinomas
- Trial name
- NCT03400865
- Testing
- HCQ/CQ and CAB combined treatment
- Where
- 9 sites in China
- Volunteers
- 30 people
- Sponsor
- Zhebao Wu
Pituitary Adenoma
Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation.
- Trial name
- NCT02574793
- Testing
- continuous glucose monitoring
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Cavernous Sinus Meningioma, Pituitary Adenoma
Effect of Irradiation of the Cavernous Sinus and the Sellar Region on Autobiographical Memory
Several studies showed that radiotherapy as brain tumors treatment may affect cognition. It was observed that durable memory impairments could arise at irradiated patients if radiotherapy is applied on medial temporal lobes.
- Trial name
- ISOMAB (NCT02750371)
- Testing
- Evaluation of autobiographical memory
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Bordeaux
Pituitary, Cancer
Clinical-pathological Evaluation of Pit-NETs
Pituitary adenomas, namely pituitary neuroendocrine tumors (PitNETs), are recognized as rare neoplasia by national and international institutions.
- Conditions
- Pituitary, Cancer, Neuroendocrine Tumors
- Trial name
- PitNET2024 (NCT06607198)
- Testing
- grading & staging, PitNET morphology analysis, Radiomics
- Where
- Italy
- Volunteers
- 940 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
In Vitro Fertilization, Polycystic Ovary Syndrome
Comparative Study of Long-acting and Short Acting Triptorelin in PCOS Patients Who Underwent IVF/ICSI
To test whether long-acting Triptorelin on pituitary down-regulation can improve the clinical pregnancy rate and reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic…
- Trial name
- NCT02477566
- Testing
- Long-acting Triptorelin, Short-acting Triptorelin
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing University
Merkel Cell Carcinoma, Islet Cell Carcinoma
Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy
RATIONALE: Antineoplastons are naturally-occurring substances that may also be made in the laboratory. Antineoplastons may inhibit the growth of cancer cells.
- Conditions
- Merkel Cell Carcinoma, Islet Cell Carcinoma, Neuroendocrine Carcinoma, Pituitary Tumor
- Trial name
- NCT00003514
- Testing
- antineoplaston A10, antineoplaston AS2-1, alternative product therapy
- Where
- United States
- Sponsor
- Burzynski Research Institute
Hypothalamic-pituitary Lesions, Craniopharyngiomas
Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions
In children treated for intracranial lesions, the 2 factors of the obesity are : the location of the lesion (hypothalamic-pituitary region) and craniopharyngiomas
- Trial name
- NCT00306683
- Testing
- DIAZOXIDE
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cushings Disease
Study of the Efficacy and Safety of Pasireotide s.c. +/- Cabergoline in Patients With Cushing's Disease
The main purpose of this prospective, multicenter, open-label phase II study, was to evaluate the efficacy and safety of pasireotide alone or in combination with cabergoline in patients with Cushing's disease.
- Trial name
- NCT01915303
- Testing
- Pasireotide with or without cabergoline
- Where
- 29 sites in United States, Argentina and 14 more
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals
Pituitary Adenoma
Comparison of Extent of Resection of Pituitary Adenoma Via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope
This randomized controlled trial, titled "Comparison of Extent of Resection of Pituitary Adenoma via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope," was conducted in the Department of Neurosurgery, Sir…
- Trial name
- GTR MRI (NCT07886242)
- Testing
- Endoscopic surgery, Microscopic surgery
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Sir Ganga Ram Hospital
Pituitary Adenoma
Detection of Functioning Pituitary Microadenoma: PET/MRI Versus PET/CT
This is a prospective case-control study to compare the usefulness of 18F-FDG PET/MRI with that of 18F-FDG PET/CT in detection of functioning pituitary microadenomas.A single dose of 370 Mega-Becquerel (MBq) 18F-FDG will be…
- Trial name
- NCT03404414
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pituitary Adenomas
The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas
The purpose of this study was to determine whether radiotherapy combined with Temozolomide is more effective than radiotherapy alone in the treatment of patients with refractory pituitary adenomas.
- Trial name
- NCT04244708
- Testing
- Radiotherapy plus temozolomide
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Pituitary Adenoma, Cushing Disease
Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors
This pilot and feasibility study aims to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for…
- Trial name
- NCT07335315
- Testing
- Contrast enhanced pituitary magnetic resonance imaging (MRI), Contrast enhanced ultrasound, Non-Contrast Ultrasound
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Osteopenia
Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density
The purpose of this project is to evaluate the hypothesis that bisphosphonate treatment given to growth hormone deficient patients (regardless of current growth hormone replacement therapy status and without changing that status)…
- Trial name
- NCT00145704
- Testing
- bisphosphonate therapy (risedronate), Vitamin D supplement, Calcium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
Craniopharyngiomas, Pituitary Macroadenoma
Randomized Controlled Clinical Study on the Prophylactic Intraoperative Use of Desmopressin in Complex Sellar Region Tumors
Craniopharyngiomas and giant invasive pituitary adenomas, with lesions originating from the pituitary stalk, are frequently associated with intraoperative and postoperative diabetes insipidus (DI).
- Conditions
- Craniopharyngiomas, Pituitary Macroadenoma, Sellar and Suprasellar Masses
- Trial name
- RCT-PIDST (NCT07712328)
- Testing
- Desmopressin (DDAVP), Control
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Zhaoyun Zhang
Cushing's Syndrome
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Participants in study C-1073-400 (NCT00569582) will be invited to participate in this extension study to examine the long term safety of mifepristone in the treatment of the signs and symptoms of endogenous Cushing's syndrome.
- Trial name
- NCT00936741
- Testing
- mifepristone
- Where
- 15 sites in United States
- Volunteers
- 30 people
- Sponsor
- Corcept Therapeutics