Clinical trials: Pituitary Disease
Growth Hormone Deficiency
Phase 2 Study of LUM-201 in Children With Growth Hormone Deficiency (OraGrowtH210 Trial)
This is a multi-national trial. The goals of the trial are to study LUM-201 as a possible treatment for Pediatric Growth Hormone Deficiency (PGHD) and investigate a predictive enrichment marker (PEM) strategy to select subjects…
- Trial name
- OraGrowtH210 (NCT04614337)
- Testing
- LUM-201, rhGH Norditropin® pen (34 µg/kg)
- Where
- 43 sites in United States, Australia and 4 more
- Volunteers
- 104 people
- Sponsor
- Lumos Pharma
CNS Tumors, Meningioma
68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.
The study population consists of patients who undergo resection for somatostatin receptor-positive (SSTR-positive) CNS tumors, focusing on meningioma, and including esthesioneuroblastoma, hemangioblastoma, medulloblastoma…
- Conditions
- CNS Tumors, Meningioma, Esthesioneuroblastoma, Hemangioblastoma
- Trial name
- DOMINO-START (NCT04081701)
- Testing
- Ga68-DOTATATE-PET/MRI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Pituitary Adenoma
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
Currently, total intravenous anesthesia (TIVA) and inhaled anesthesia are both commonly used for transsphenoidal pituitary adenoma resection.
- Trial name
- NCT05822817
- Testing
- sevoflurane, propofol
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking Union Medical College Hospital
Pituitary Adenomas
The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas
The purpose of this study was to determine whether radiotherapy combined with Temozolomide is more effective than radiotherapy alone in the treatment of patients with refractory pituitary adenomas.
- Trial name
- NCT04244708
- Testing
- Radiotherapy plus temozolomide
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Hypopituitarism, Insulin Resistance
Lipolytic Effects of GH in Hypopituitary Patients in Vivo
Growth hormone (GH) is essential for longitudinal bone growth and somatic development. These protein anabolic effects require sufficient nutritional supply.
- Conditions
- Hypopituitarism, Insulin Resistance, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02782208
- Testing
- Acipimox, GH substitution, GH pause
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Pituitary Macroadenoma
Utilization of iMRI for Transsphenoidal Resection of Pituitary Macroadenomas
The investigators are studying the utility of intra-operative magnetic resonance imaging (iMRI) during transsphenoidal pituitary surgery for large macroadenomas by randomizing patients to either an intra-operative MRI after…
- Trial name
- NCT02396810
- Testing
- intra-operative MRI, Transsphenoidal resection of pituitary macroadenoma
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acromegaly
PegvisOMant and the Immune SystEm (PROMISE)
This is a prospective observational pilot study for the evaluation of immune cells phenotype in acromegalic patients in comparison with a control population and to investigate the impact of disease control and different medical…
- Trial name
- NCT05069324
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Roma La Sapienza
Pituitary Tumors
Safety and Efficacy of FolateScan (Technetium Tc 99m EC20) in Subjects With Pituitary Tumors
Many types of cancers overexpress a receptor for the vitamin folate (Folate Receptor). This Phase 2 study will utilize a standard imaging radionuclide, technetium-99m, conjugated to a ligand (EC20) designed to bind to the folate…
- Trial name
- NCT01689727
- Testing
- Technetium Tc 99m EC20
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Endocyte
Acromegaly
One Year Follow-up of Study 2-79-52030-207 (PRIMARYS) in Acromegalic Patients With Macroadenoma
This non-interventional retrospective study aims to describe the therapeutic procedures and modalities received by patients and the correlation to hormone status, during a one year follow up from completion of the 2-79-52030-207…
- Trial name
- NCT01471405
- Where
- 18 sites in Czechia, France and 4 more
- Volunteers
- 54 people
- Sponsor
- Ipsen
Pituitary Tumor
Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery
This is a prospective, single-blinded, multicenter study evaluating the benefit of sinonasal irrigations following endoscopic pituitary surgery.
- Trial name
- NOSE (NCT05659524)
- Testing
- Nasal saline irrigation
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Lori Wood
Acromegaly, Excessive Growth Hormone Secretion
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
- Conditions
- Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance
- Trial name
- NCT00647179
- Testing
- Transsphenoidal adenomectomy
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Growth Hormone Deficiency
Safety, Pharmacokinetics and Pharmacodynamics Study of HL-032 in Healthy Male Volunteers
The purpose of this study is to evaluate the safety, pharmacokinetics and pharmacodynamics of HL-032 after oral administration in healthy male volunteers.
- Trial name
- HL-032 (NCT01440686)
- Testing
- Somatropin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- HanAll BioPharma Co., Ltd.
Cognitive Dysfunction, Opioid Free Anesthesia
Postoperative Cognitive Dysfunction in Transsphenoidal Pituitary Surgeries
In this study, the patients undergoing pituitary surgery in our clinic have examined in two groups. In the first group, anesthesia maintenance was provided with remifentanil and propofol infusion.
- Trial name
- NCT06793150
- Testing
- Remifentanil, dexmedetomidin
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kocaeli University
Cushing's Disease, Hypercortisolism
Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection
Cushing's disease is a rare condition where the body produces too much of a hormone called cortisol. Cortisol helps with metabolism, the immune system, and managing stress.
- Conditions
- Cushing's Disease, Hypercortisolism, Pituitary Adenoma, Pituitary ACTH Secreting Adenoma
- Trial name
- OPTIMAL (NCT06701838)
- Testing
- 11C-Methionine PET/CT
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Pregnancy, Children
Effectiveness of a multicOmpoNent Behavioural intervenTion to Reduce endocrINe disrUptor Exposure During pErinatal Period (CONTINUE)
The general objective of HYPIEND is to understand the effects of chemical substances called "endocrine disruptors" (EDCs) during the perinatal and pre-pubertal stages.
- Trial name
- CONTINUE (NCT07142447)
- Testing
- Multi-Component Behavioral intervention, Control group
- Where
- Spain
- Volunteers
- 810 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Hyperprolactinemia, Prolactinoma
Treatment of Hyperprolactinemia With the Non-ergoline Dopamine Agonist Ropinirole
The purpose of this study is to evaluate the use of the non-ergoline dopamine agonist ropinirole for the treatment of hyperprolactinemia in patients with idiopathic hyperprolactinemia and prolactinomas.
- Trial name
- NCT03038308
- Testing
- Ropinirole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Dwarfism, Pituitary
A Study to Learn About Somatrogon in Patients With Pediatric Growth Hormone Deficiency (p GHD) in India.
The purpose of this study is to learn about the safety of Somatrogon for the treatment of pediatric growth hormone deficiency (p GHD) in India.
- Trial name
- NCT06587035
- Testing
- Somatrogon
- Where
- 4 sites in India
- Volunteers
- 50 people
- Sponsor
- Pfizer
Aneurismal Subarachnoid Hemorrhage, Hypopituitarism
Hypopituitarism After Aneurismal Subarachnoid Hemorrhage
Introduction: Almost 50% of patients die after aneurismal subarachnoid hemorrhage (aSAH). 30% of the survivors suffer from neurological handicap and need permanent care (Suarez et al.).
- Conditions
- Aneurismal Subarachnoid Hemorrhage, Hypopituitarism, Neuropsychological Deficits
- Trial name
- NCT00962559
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Growth Hormone, Recombinant, Fatty Liver
The Effect of Growth Hormone Replacement on Liver Fat
We will examine a cohort of growth hormone deficient adults starting growth hormone (GH) replacement. The purpose of this study is to determine whether GH replacement reduces the fat content of the liver.
- Trial name
- NCT00774579
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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