Clinical trials: Pituitary Disease
Acromegaly
Pasireotide LAR and Pegvisomant Study in Acromegaly
The objective of this study is to assess the efficacy of Pasireotide Long Acting Release (LAR) alone and in combination with weekly Pegvisomant (PEGV) in acromegaIy patients previously controlled with combination treatment of…
- Trial name
- PAPE (NCT02668172)
- Testing
- Pasireotide LAR 60 mg, Pegvisomant
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Pituitary Adenoma
Application Research on Endoscopic Pseudocapsule-Based Resection for Pituitary Adenomas
Pituitary adenomas are one of the most common primary central nervous system tumors and have an estimated prevalence of 17%. Management of pituitary adenomas involves a multidisciplinary approach that can incorporate surgical…
- Trial name
- NCT05466357
- Testing
- Excision of pituitary tumor outside pseudocapsule
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Nantong University
Hyponatremia, Syndrome of Inappropriate Antidiuresis
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
- Trial name
- TREASUREx (NCT06821802)
- Testing
- Moltein PURE Protein Powder, Fluid restriction
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Acromegaly
An Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Edge)
An open label exploratory study designed to evaluate the safety, efficacy, and pharmacokinetics of paltusotine (formerly CRN00808) in subjects with acromegaly that are treated with somatostatin analogue (SSA) based treatment…
- Trial name
- NCT03789656
- Testing
- Paltusotine
- Where
- 26 sites in United States, Brazil and 10 more
- Volunteers
- 47 people
- Sponsor
- Crinetics Pharmaceuticals Inc.
Cushing's Disease
Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease
Cushing's disease is a state of chronic endogenous glucocorticoid excess. Cushing's disease is responsible for increased morbidity and mortality.
- Trial name
- MEMOCUSH (NCT02603653)
- Testing
- Virtual radial task in 3D
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Glioblastoma, Glial Tumor
Evaluation of the CONVIVO System
The primary objective of this study is to evaluate the diagnostic performance of the CONVIVO confocal endomicroscope in discriminating between normal and abnormal tissue in vivo during brain tumor surgery.
- Conditions
- Glioblastoma, Glial Tumor, Brain Metastases, Meningioma
- Trial name
- NCT05139277
- Testing
- CONVIVO system, Conventional histologic evaluation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Surgery--Complications
Incidence of Rhinological Morbidities During Endonasal Pituitary Surgery, With or Without Nasoseptal Flap
Determine and compare prospectively the incidence of rhinological adverse events during pituitary surgery with or without nasoseptal flap
- Trial name
- HLNS (NCT04493801)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Brest
Acromegaly Due to Pituitary Adenoma, Ketogenic Diet
KETOgenic Diet Therapy in Patients With ACROmegaly
Acromegaly is caused by a tumour located at the base of the brain in the pituitary gland that produces too much growth hormone (GH).
- Conditions
- Acromegaly Due to Pituitary Adenoma, Ketogenic Diet, Mediterranean Diet
- Trial name
- KETOACRO (NCT06949891)
- Testing
- Ketogenic diet, Mediterranean diet
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Acromegaly
A Phase 1 Study to Evaluate the Relative Bioavailability of Octreotide Acetate Tablets(T25) Compared to MYCAPSSA® and The Food Effect on Pharmacokinetics Of Octreotide Acetate Tablets(T25)
The goal of this clinical trial] is to to Assess the Food Effect on the Relative Bioavailability of Orally Administrated T25 in healthy volunteers. The main questions it aims to answer are： 1.
- Trial name
- NCT07663318
- Testing
- T25-Fast, Mycapssa, T25-Fed
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Triastek (Shanghai) Limited
Metabolic Syndrome, Hypersecretion; Cortisol
Effects of IL-1 Beta on the HPA-axis in Obese Persons
In obese individuals cortisol production and secretion is increased but the underlying mechanism is not known. Obesity leads to a pathological activation of the innate immune system partly driven by tissue production of IL-1β.
- Trial name
- CortIL (NCT02227420)
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- University Hospital, Basel, Switzerland
Acromegaly
Long-term Safety and Efficacy Study of Octreotide Implant in Patients With Acromegaly
This is a long term study to evaluate the safety, tolerability and efficacy of an Octreotide Implant in patients that were previously treated with an Octreotide implant.
- Trial name
- NCT01295060
- Testing
- Octreotide
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Acromegaly, Growth Hormone Deficiency
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States
Growth hormone (GH) is important for growth in childhood, but also has important effects on a number of tissues throughout life.
- Trial name
- NCT00461240
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Barts & The London NHS Trust
Meniere Disease
Vasopressin and V2 Receptor in Meniere's Disease
Summary: Some of sicknesses are well known to be provoked by inadequate adaptation to physical and/or psychogenic stress in their daily life.
- Trial name
- NCT00599560
- Testing
- vasopressin, V2 receptor and cyclic AMP
- Where
- Japan
- Volunteers
- 135 people
- Sponsor
- Osaka University
Acromegaly
A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.
If someone is diagnosed with a pituitary tumor that causes acromegaly (too much growth hormone) the treatment is to have it surgically removed. This study has two phases.
- Trial name
- NCT01861717
- Testing
- lanreotide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Saint John's Cancer Institute
Hyponatremia, Inappropriate ADH Syndrome
A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia
The primary objective of this study is to assess the efficacy of satavaptan versus placebo in participants with dilutional hyponatremia due to SIADH.
- Trial name
- AQUARIST1 (NCT00728091)
- Testing
- Satavaptan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sanofi
Acute Pancreatitis, Pancreatitis
Study of Copeptin as a Diagnostic Marker for Acute Pancreatitis
The purpose of this study is to investigate if there is an association between copeptin level in serum and the severity of pancreatitis and if copeptin can be used as a predictor for organ failure and pancreatic necrosis with or…
- Trial name
- COPA (NCT01293318)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Growth Hormone Deficiency, Endocrine System Diseases
Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Chinese Pediatric Growth Hormone Deficiency
This study is conducted in China only. The purpose is to demonstrate the efficacy and safety of once weekly dosing of TransCon hGH, a long-acting growth hormone product, compare to once-daily dosing of human growth hormone (hGH)…
- Conditions
- Growth Hormone Deficiency, Endocrine System Diseases, Hormones, Pituitary Diseases
- Trial name
- NCT04326374
- Testing
- TransCon hGH, daily hGH
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Visen Pharmaceuticals (Shanghai) Co., Ltd.
Pituitary Adenomas
Predictive Factors of Recurrence of Non Functioning Pituitary Adenomas : a Retrospective Study of 220 Patients in the Reims University Hospital, France
Non functioning pituitary adenomas (NFPAs) are the most common pituitary adenomas. Their growth is usually slow and diagnosis is often made in the context of masse effect .The therapeutic alternatives are surgery and radiotherapy…
- Trial name
- NCT02803697
- Testing
- Patients
- Where
- France
- Volunteers
- 106 people
- Sponsor
- CHU de Reims
Acromegaly
Effects of Sandostatin LAR® in Acromegaly
This study aims primarily to determine the effect Insulin-like Growth Factor 1 (IGF-1) normalization into current IGF-I normal ranges with Sandostatin LAR® therapy on biochemical metabolic, cardiovascular and body composition…
- Trial name
- NCT01424241
- Testing
- Sandostatin LAR
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Columbia University
Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric
A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children
Plain Language Summary: Background Glucocorticoids are stress hormones produced by the human body to control inflammation and regulate the immune system. Cortisol is the most well-known example of a glucocorticoid.
- Conditions
- Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric, Lymphoma, Lymphoblastic
- Trial name
- LeukemiaCort (NCT06861530)
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital Basel
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