Clinical trials: Pituitary Disease
Metabolic Syndrome, Hypersecretion; Cortisol
Effects of IL-1 Beta on the HPA-axis in Obese Persons
In obese individuals cortisol production and secretion is increased but the underlying mechanism is not known. Obesity leads to a pathological activation of the innate immune system partly driven by tissue production of IL-1β.
- Trial name
- CortIL (NCT02227420)
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- University Hospital, Basel, Switzerland
Pituitary Adenoma
Surgical Debulking of Pituitary Adenomas
This is a randomized, multicenter trial with stratification done by a single radiologist at the coordinating center (NYU), and patients with comparable disease will be randomized to Sandostatin LAR treatment administered 1 time…
- Trial name
- NCT01371643
- Testing
- Octreotide LAR, transsphenoidal surgery
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels
The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU
Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and characerized by polyuria, is a common complication after neurosurgerical…
- Conditions
- Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels, Copeptin, Neurosurgical Intervention
- Trial name
- NCT06742060
- Testing
- serum copeptin levels
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Dwarfism, Pituitary
National Cooperative Growth Study (NCGS) of Optimal Nutropin AQ and Nutropin Dosing in Pubertal Growth Hormone-Deficient (GHD) Patients
This study is a multicenter, open-label, observational, postmarketing surveillance study that will collect information on the use of Genentech GH preparations to treat GH-deficient subjects with optimal GH dosing during puberty.
- Trial name
- NCT00097513
- Where
- United States
- Sponsor
- Genentech, Inc.
Acromegaly
ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly
The primary objective of this study is to evaluate the efficacy of 15-week treatment with ALXN2420 versus placebo for decreasing insulin-like growth factor IGF-1 levels, when administered in combination with somatostatin analog…
- Trial name
- ASTERIA (NCT07037420)
- Testing
- ALXN2420
- Where
- 6 sites in United States, Italy and 2 more
- Volunteers
- 8 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Arginine Vasopressin Deficiency, Primary Polydipsia
Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP…
- Trial name
- URANOS (NCT05890690)
- Testing
- Urea
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pituitary Tumor, Meningioma
Long-Term Longitudinal QoL in Patients Undergoing EEA
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
- Conditions
- Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma
- Trial name
- NCT04087902
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University
Acromegaly
A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly
The purpose of the study is to determine if Pegvisomant is more efficacious than Sandostatin LAR Depot in normalizing IGF-I levels in treatment naive patients with acromegaly.
- Trial name
- NCT00068042
- Testing
- Pegvisomant, Sandostatin LAR
- Where
- 55 sites in United States, Australia and 11 more
- Volunteers
- 100 people
- Sponsor
- Pfizer
Cushing Syndrome
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)
This is an observational, open, prospective multi-centre study designed to evaluate melatonin and cortisol circadian rhythm, immunological profile and anthropometric parameters in Cushing Syndrome patients during active Remission…
- Trial name
- TheHOURS (NCT03343470)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Prolactinoma
Exercise Capacity and Physical Activity Level in Prolactinoma Patients
Prolactinoma, one of the most common pituitary adenomas, is an adenoma that causes excessive prolactin (PRL) secretion. An increase in prolactin level can cause weakness, decrease in muscle mass and fatigue.
- Trial name
- NCT05236829
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hyperprolactinemia
Double-Blind Placebo Controlled Study of Adjunctive Aripiprazole for Symptomatic Hyperprolactinemia In Premenopausal Women With Schizophrenia
Prolactin is a hormone that naturally occurs in the body. Some women taking antipsychotic medications may have high levels of prolactin in their bodies.
- Trial name
- DAAMSEL (NCT01338298)
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Pituitary Neoplasms
Radiomic and Pathomic Study of Pituitary Adenoma Using Machine Learning
Refractory pituitary adenoma is characterized by invasive tumor growth, continuous growth and/or hormone hypersecretion in spite of standardized multi-modal treatment such as surgeries, medications or radiations.
- Trial name
- NCT05108064
- Testing
- Artificial intelligence model
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Type 1 Diabetes, Diabetes Insipidus
Tracking Neurodegeneration in Early Wolfram Syndrome
The goal of this study is to determine the pattern of early neurodegenerative changes in WFS (Wolfram Syndrome). The investigator will perform cross-sectional and longitudinal assessments of youth with WFS, targeting sensitive…
- Conditions
- Type 1 Diabetes, Diabetes Insipidus, Diabetes Mellitus, Wolfram Syndrome
- Trial name
- TRACK (NCT02455414)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Headache, Pituitary Tumor
The TMS Treatment for Postoperative Headache in GH Tumor
Headache is a very common main complaint of patients with GH pituitary tumor, which has seriously affected the normal work and life of patients.
- Conditions
- Headache, Pituitary Tumor, Acromegaly
- Trial name
- NCT04529356
- Testing
- Transcranial magnetic stimulation, Acetaminophen
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hyponatremias, Water Intoxication
"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia
This study's purpose is to determine whether tolvaptan can safely and effectively return the body's balance of sodium and water toward normal, and to characterize and quantify the potential clinical benefits of this treatment.
- Conditions
- Hyponatremias, Water Intoxication, Inappropriate ADH Syndrome, Water-Electrolyte Imbalances
- Trial name
- NCT00072683
- Testing
- tolvaptan
- Where
- 23 sites in United States
- Volunteers
- 205 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Acromegaly
Treatment of Acromegaly With Somatostatin Analogs: GH vs. IGF-I as Primary Biochemical Target
Treatment of acromegaly with somatostatin analogs (SA) is well-established and are primarily used after insufficient surgical intervention, but also as primary medical treatment in selected patients.
- Trial name
- NCT01618513
- Testing
- Sandostatin® LAR
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Autism Spectrum Disorders
Brain Imaging Study of Adults With Autism Spectrum Disorders
This research study investigates the effects of oxytocin and vasopressin on brain activity in adults with Autism Spectrum Disorders using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT01093768
- Testing
- Oxytocin, Vasopressin
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Inappropriate ADH Syndrome, Hyponatremia
Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
To determine the long-term safety and tolerability of SR121463B in patients with syndrome of inappropriate antidiuretic secretion (SIADH).
- Trial name
- SIADH Safety (NCT00264914)
- Testing
- SR121463B
- Where
- 11 sites in United States, Australia and 9 more
- Volunteers
- 57 people
- Sponsor
- Sanofi
Pregnancy, Stress
Effects of Stress on Glucose Tolerance During Pregnancy
The objective of the study is to investigate the effect of stress on glucose tolerance during pregnancy. The main objectives of the study are to investigate if various measures of stress (stressful life events, the perceived…
- Conditions
- Pregnancy, Stress, Gestational Diabetes
- Trial name
- NCT01707784
- Where
- Switzerland
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Growth Hormone Deficiency, Pituitary Tumor
Assessment of Cardiovascular Risk Markers in Growth Hormone Deficient Patients With Nonsecreting Pituitary Adenomas
The purpose of this study is to determine if patients with a history of nonsecreting pituitary adenomas with untreated GH deficient patients have profiles consistent with increased cardiovascular risk compared to patients without…
- Trial name
- NCT00646308
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
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