Clinical trials: Pituitary Disease
Adult Growth Hormone Deficiency, Hypothalamic-pituitary Disorders
The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis
The purpose of this study is to find out if the Glucagon Stimulation Test (GST) is a reliable alternative to the Insulin Tolerance Test (ITT) for diagnosis of Growth Hormone Deficiency (GHD) and adrenal insufficiency.
- Trial name
- GST (NCT01282164)
- Testing
- Glucagon stimulation test and insulin tolerance test
- Where
- 4 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alcohol Dependence
Stress, Hypothalamic-pituitary-adrenal (HPA) Dysfunction, and Relapse in Alcoholism
This proposal is part of the INIA Stress Consortium. This study will 1. explore the contributions of lifetime trauma, recent stress, and alcohol use on stress-hormone axis disruption in treatment seeking, one-month abstinent…
- Trial name
- NCT00744588
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Pituitary Adenoma Invasive, Nasal Obstruction
Nasal Obstruction Compared by Rhinomanometry and Nasal Inspiratory Peak Flow After Endoscopic Nasal Surgery
The aim of the project is to determine whether nasal inspiratory peak flow is sufficient for preoperative and postoperative measurement of nasal patency compared to rhinomanometry.
- Trial name
- NCT05921396
- Testing
- Nasal patency - rhinomanometry, Nasal patency - nasal inspiratory peak flow
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Cardiac Surgery, Hypertension, Pulmonary
The Effect of Pituitrin on the Patients With Pulmonary Hypertension Undergoing Cardiac Surgery
This study is a parallel group, single blind, randomized controlled trial. Patients with pulmonary hypertension who met the inclusion criteria and planned to undergo elective cardiac surgery under cardiopulmonary bypass from July…
- Trial name
- NCT05727618
- Testing
- Pituitrin, normal saline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Enhanced Recovery After Surgery, Pituitary Tumor
To Assess the Impact of theERAS Consensus on Patients With Endoscopic Pituitary Tumor Surgery
The goal of this observational study is to evaluate the effectiveness and impact of Enhanced Recovery After Surgery (ERAS) on patients with pituitary gland tumors.
- Conditions
- Enhanced Recovery After Surgery, Pituitary Tumor, Postoperative Complications
- Trial name
- NCT06221020
- Testing
- Malnutrition Universal Screening Tool, TIB Olfactory Test Device, Apfel Score for Postoperative nausea and vomiting
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Growth Hormone Deficiency
Development and Validation of a Self-assessment System Based on a Mobile App to Manage Adult Growth Hormone Deficiency
Adult Growth Hormone Deficiency (AGHD) is a recognized clinical entity but several barriers concerning patient-clinician communication, inadequate patients' awareness of the disease, low perceived benefit of replacement therapy…
- Trial name
- GrASS (NCT03525587)
- Testing
- Use of "MAGHD App/MAGHD Framework"
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Acromegaly, Obstructive Sleep Apnea
Sleep Apnea Syndrome on Acromegaly: Impact of the Treatment on the Carbohydrates Metabolism.
Sleep apnea is a common situation that affects up to 80% of acromegalic patients. This disease is linked to disturbance on the carbohydrate metabolism increasing the rates of diabetes.
- Conditions
- Acromegaly, Obstructive Sleep Apnea, Insulin Resistance
- Trial name
- NCT01265121
- Testing
- Continuous positive air pressure device (CPAP), External nasal dilator adhesive
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- University of Sao Paulo General Hospital
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Craniopharyngioma
Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma
With the preliminary anatomical and histological study, the membranous structures of the sellar region was considered to be closely related with the growth pattern of Craniopharyngiomas(CP).
- Trial name
- NCT00949156
- Testing
- Different surgical approach and techniques being used to treat three subtype of CP
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Southern Medical University, China
Iron Overload
Changes in Pituitary Iron and Volume With Deferasirox
Despite continuing advances in iron chelation therapy, iron toxicity of endocrine glands, particularly the pituitary gland, remains common in patients with transfusion dependent anemias.
- Trial name
- NCT01376622
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Growth Hormone-Deficiency
A Phase 2, Safety and Dose-Finding Study in Treatment-Naive, Pre-Pubertal, Growth Hormone-Deficient Children
The purpose of this study is to support selection of an appropriate safe and efficacious dose for study in further development.
- Trial name
- NCT02092077
- Testing
- TV-1106, somatropin
- Where
- 34 sites in Belarus, Bulgaria and 11 more
- Volunteers
- 65 people
- Sponsor
- Teva Pharmaceutical Industries, Ltd.
Growth Hormone Deficiency
A Study of Zomacton in Children With Growth Hormone Deficiency
This trial is set up to compare Zomacton to Genotropin for the treatment of growth hormone deficiency in children. The children will be treated for 1 year.
- Trial name
- NCT00884000
- Testing
- Genotropin, Zomacton
- Where
- 43 sites in Hungary, India and 5 more
- Volunteers
- 165 people
- Sponsor
- Ferring Pharmaceuticals
Pituitary Tumor
Nasal Irrigation Apply in Patients After Transsphenoidal Pituitary Tumor Resection
Transsphenoidal pituitary tumor resection is currently recognized as an effective and safe surgical method,nowadays it is widely used in clinical practice .
- Trial name
- NCT03933241
- Testing
- nasal irrigation
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypoosmolality, Hyperosmolality
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2.
- Conditions
- Hypoosmolality, Hyperosmolality, Renal Failure
- Trial name
- NCT00696605
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Centre Biel/Bienne
Healthy
Differential Effects of Vasopressin and Oxytocin on Attention Control
The main aim of the present study is to investigate whether intranasal vasopressin (20IU) and oxytocin (24IU) have differential effects on attention control in a social-emotional saccade/antisaccade eye-tracking paradigm.
- Trial name
- NCT04715737
- Testing
- Vasopressin, Oxytocin
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Pituitary Adenoma, Pituitary Cancer
A Twenty-years' Experience in Pituitary Disease.
Pituitary tumors represent a heterogeneous group of neoplasms by histotype. The pituitary adenomas are the most frequent heteroformation, among those affecting the pituitary gland, followed by meningiomas, craniopharyngiomas…
- Conditions
- Pituitary Adenoma, Pituitary Cancer, Pituitary Disease
- Trial name
- TYEPDD (NCT06973824)
- Testing
- Frequency of disease recurrence
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Autosomal Dominant Polycystic Kidney Disease
High Water Intake in Polycystic Kidney Disease
DRINK is an open-label randomised controlled feasibility trial of high versus ad libitum water intake in ADPKD.
- Trial name
- DRINK (NCT02933268)
- Testing
- High water intake, Ad libitum water intake
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Growth Hormone Deficiency, Idiopathic Short Stature
Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature
This study evaluates long-term safety and effectiveness of Growtropin®-II treatment in children with short stature.
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Turner Syndrome, Small for Gestational Age
- Trial name
- NCT04798690
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Dong-A ST Co., Ltd.
Septic Shock, Vasodilatory Shock
Vasopressin Use in Septic Shock From Türkiye
The goal of this observational study is to examine the early hemodynamic effects and clinical outcomes of vasopressin use in patients with septic shock.
- Conditions
- Septic Shock, Vasodilatory Shock, Critical Illness Sepsis, Severe, Critical Illness
- Trial name
- (VASCO-TURK) (NCT06953297)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Karadeniz Technical University
Obstructive Sleep Apnea Syndrome, Obesity
Influence of nCPAP on Metabolic Consequences Associated With OSAS
Context: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity. Recurrent episodes of occlusion of upper airways during sleep result in hormonal changes that may predispose to high cardiovascular…
- Trial name
- NCT00435643
- Testing
- nasal continuous positive airway pressure
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
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