Clinical trials: Pituitary Disease
Female Infertility
Single Dose FSH-GEX™ in Healthy Volunteers
The aim of the current study was the pharmacokinetic and pharmacodynamic characterization of a single dose administration of four doses of FSH-GEX™ in healthy pituitary-suppressed female volunteers, in comparison with two…
- Trial name
- NCT01354886
- Testing
- FSH-GEX™, Gonal-f, Bravelle
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Glycotope GmbH
ULTRASOUND-GUIDED PERCUTANEOUS VERSUS TRANS-NASAL PTERYGOPALATINE FOSSA BLOCK IN ENDOSCOPIC TRANS-SPHENOIDAL PITUITARY GLAND SURGERY
Sphenopalatine Ganglion Block in Endoscopic Transphenoidal Pituitary Gland Surgery
The primary aim of this study is to compare the effect of bilateral US guided percutaneous PPFB versus transnasal approach on intraoperative anaesthetic requirements (guided by entropy) in patients undergoing endoscopic…
- Trial name
- NCT06836583
- Testing
- trans-nasal pterygopalatine Fossa block, US-guided infrazygomatic percutaneous pterygopalatine Fossa block
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Donia Hany Saad
Pituitary Tumor
Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia
Investigators hypothesized that propofol dose for pituitary somatotroph patients might differ from nonfunctioning pituitary tumor, and investigators will evaluate a target controlled infusion (TCI) effect site concentration (Ce)…
- Trial name
- NCT03465423
- Testing
- Not applicable (measuring subject's effect site concentration of propofol during the induction of general anesthesia)
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Yonsei University
Menopause, Hypertension
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
Calcitonin, calcitonin gene-related peptides (CGRPs), adrenomedullin, and amylin belong to a unique group of peptide hormones important for the regulation of calcium balance, neurotransmission, cardiovascular homeostasis, and…
- Trial name
- NCT00133783
- Testing
- intermedin
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cushing's Syndrome
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
This is an observational study to confirm the presence of recurrent or persistent endogenous Cushing's syndrome in patients who have had primary surgical and/or radiation therapy for Cushing's disease and continue to manifest…
- Trial name
- NCT00796783
- Testing
- Cushing's syndrome confirmation
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Corcept Therapeutics
Pituitary Adenoma
OCT-angiography as a Pronostic Marker for Visual Impairment in Patients Undergoing Neurosurgery for Compressive Macroadenoma : a Prospective Study.
The aim of the study is to assess accurancy of OCT angiography as a pronostic marker for patients undergoing neurosurgery for compressiver macroadenoma as compared with visual acuity, visual field and OCT.
- Trial name
- FIRST (NCT04074642)
- Testing
- Neurosurgery
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Central Precocious Puberty (CPP), Puberty Disorders
Spexin and Phoenixin-20 in Girls With Central Precocious Puberty
Central precocious puberty (CPP) is characterized by the early activation of the hypothalamic-pituitary-gonadal axis in girls and may be difficult to distinguish from benign variants such as premature thelarche.
- Conditions
- Central Precocious Puberty (CPP), Puberty Disorders, Puberty, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
- Trial name
- SPX-PNX-CPP-20 (NCT07359092)
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
SIAD - Syndrome of Inappropriate Antidiuresis, Hyponatremia
Water Load Test Value for Hyponatremia
Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test.
- Trial name
- WATERLINE (NCT04256499)
- Testing
- Acute water load test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- European Georges Pompidou Hospital
Oxytocin Deficiency, Hypopituitarism
Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Oxytocin Deficiency, Hypopituitarism, Hypothalamic Obesity, Pituitary Dysfunction
- Trial name
- NCT05319301
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Vasopressin Causing Adverse Effects in Therapeutic Use, Shock
Registry of Patients in Shock Treated With Vasopressin
Arginine-vasopressin (AVP) is a non-catecholaminergic hormone produced in the hypothalamus and released into the circulation via the neurohypophysis.
- Conditions
- Vasopressin Causing Adverse Effects in Therapeutic Use, Shock, Vasopressor Adverse Reaction, Vasopressin Deficiency
- Trial name
- NCT06422975
- Testing
- Vasopressin
- Where
- 24 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario 12 de Octubre
Acromegaly
A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)
A phase 2, open label, long-term extension study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with…
- Trial name
- NCT04261712
- Testing
- Paltusotine
- Where
- 22 sites in United States, Brazil and 5 more
- Volunteers
- 43 people
- Sponsor
- Crinetics Pharmaceuticals Inc.
Healthy
Common and Differentiated Representations Between Social Exclusion and Social Separation
Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.
- Trial name
- NCT05920707
- Testing
- Intranasal Oxytocin, Intranasal Arginine Vasopressin
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Secondary Adrenal Insufficiency
Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function
The use of intravitreal corticosteroids in the management ocular inflammatory diseases has recently gained widespread acceptance.
- Trial name
- NCT00561236
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- HaEmek Medical Center, Israel
Schizophrenia Spectrum and Other Psychotic Disorders, Periodontal Diseases
Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
The aim of the present cohort retrospective study is to explore the effect of antipsychotics on periodontal health and the possible effect of antipsychotic-induced hyperprolactinemia as a risk factor for periodontal disease…
- Trial name
- NCT06040944
- Testing
- antipsychotic drugs inducing hyperprolactinemia
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Fayoum University
Gulf War Syndrome, Adult Growth Hormone Deficiency
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)
The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD).
- Trial name
- GWIT (NCT05355272)
- Testing
- Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Pituitary Adenoma
Nasoseptal Double Flap Versus Rescue Flap in Endoscopic Transsphenoidal Pituitary Surgery
This paper investigates the outcomes of two surgical techniques-nasoseptal double flap and nasoseptal rescue flap-used in endoscopic transsphenoidal surgery for pituitary tumors.
- Trial name
- NCT06526481
- Testing
- Endoscopic Transsphenoidal pituitary surgery : Double Nasoseptal Flap Technique, Endoscopic Transsphenoidal pituitary surgery : Rescue Flap Technique
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Acromegaly, Pituitary Gigantism
Efficacy and Safety of Pasireotide LAR (Long-acting Release) in Japanese Patients With Acromegaly or Pituitary Gigantism
To evaluate efficacy, safety, pharmacokinetics and pharmacodynamics of pasireotide LAR in Japanese patients with active acromegaly or pituitary gigantism.
- Trial name
- NCT01673646
- Testing
- Pasireotide LAR
- Where
- 27 sites in Japan
- Volunteers
- 33 people
- Sponsor
- Novartis Pharmaceuticals
Excess Intake of Macronutrients, Excess Intake of Micronutrients
Water and Coffee Intervention in Humans
39 healthy subjects without medication (except oral contraceptives) aged 20-70 years are recruited via advertisements or through telephone contacts with individuals that had previously participated in population-based cohort…
- Conditions
- Excess Intake of Macronutrients, Excess Intake of Micronutrients, Vasopressin Low
- Trial name
- NCT06165185
- Testing
- Water, Coffee, Control
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Region Skane
Adult Growth Hormone Deficiency
Versartis International Trial in Adults With Long-Acting Growth Hormone
A Phase 2, open-label dose-finding safety study of individualized monthly VRS-317 dosing for five months in adults with GHD.
- Trial name
- VITAL (NCT02526420)
- Testing
- somavaratan
- Where
- 18 sites in United States, Australia and 2 more
- Volunteers
- 36 people
- Sponsor
- Versartis Inc.
Pituitary Adenoma
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
Currently, total intravenous anesthesia (TIVA) and inhaled anesthesia are both commonly used for transsphenoidal pituitary adenoma resection.
- Trial name
- NCT05822817
- Testing
- sevoflurane, propofol
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking Union Medical College Hospital
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