Clinical trials: Pituitary Disease
Placenta Previa
Tranexamic Acid vs Vasopressin in Placenta Previa Trial
Placenta previa is a major obstetric condition associated with increased risk of excessive blood loss during cesarean section, leading to maternal morbidity and mortality.
- Trial name
- TXA-VASO-PP (NCT07423156)
- Testing
- Group A: Tranexamic acid, Group B: Vasopressin
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Allama Iqbal Medical College
Pituitary Adenoma
AI in Endoscopic Transsphenoidal Surgery
This study focuses on bringing artificial intelligence into the operating room to assist with pituitary tumour surgeries performed through the nose.
- Trial name
- NCT07568366
- Testing
- Live intra-op AI analysis of endoscopic video feed, with output displayed on supplementary monitor
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain
In 2014, the Spanish Sociedad Española de Oncología Médica (SEOM) algorithm for the treatment of hyponatraemia secondary to to syndrome of inappropriate antidiuretic hormone (SIADH) in oncology patients was developed.
- Trial name
- ALGA (NCT02548845)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
CerebroSpinal Fluid (CSF) Leak
NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery
Postoperative cerebrospinal fluid (CSF) leak is a significant complication of endoscopic endonasal approaches (EEA) to the skull base.
- Trial name
- NoSeal (NCT07216157)
- Testing
- Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant
- Where
- Poland
- Volunteers
- 225 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Hyponatremia, Inappropriate ADH Syndrome
A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia
The primary objective of this study is to assess the efficacy of satavaptan versus placebo in participants with dilutional hyponatremia due to SIADH.
- Trial name
- AQUARIST1 (NCT00728091)
- Testing
- Satavaptan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sanofi
Growth Hormone Deficiency, Short Stature
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy
The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy.
- Trial name
- ETABIOGHD (NCT06294860)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Acromegaly
Study Comparing SOM230 Subcutaneously and Sandostatin Subcutaneously in Acromegalic Patients
5 month study comparing SOM230 s.c. and Sandostatin s.c. in acromegalic patients.
- Trial name
- NCT00088582
- Testing
- Pasireotide (SOM230), Octreotide (Sandostatin)
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Growth Hormone Disorder, Adult Growth Hormone Deficiency
French National Registry of Adults With Growth Hormone Deficiency Treated With Somatropin
This study is conducted in Europe. The aim of this study is to extract data from the French National Registry holding information about patients having initiated growth hormone therapy with the objective to describe patients…
- Trial name
- NCT01580605
- Testing
- somatropin
- Where
- France
- Volunteers
- 331 people
- Sponsor
- Novo Nordisk A/S
Adult Growth Hormone Deficiency
A Phase 3, Multicenter Study To Evaluate The Efficacy And Safety Of MOD-4023 In Adults With Growth Hormone Deficiency
This will be a randomized, double-blind, placebo-controlled, parallel-group, multicenter study in adult subjects with GHD to assess the safety and efficacy of a long-acting, once weekly injection of modified hGH (MOD-4023).
- Trial name
- NCT01909479
- Testing
- MOD-4023
- Where
- Israel
- Volunteers
- 202 people
- Sponsor
- OPKO Health, Inc.
Growth Hormone Deficiency
Study to Assess Safety and Tolerability in Adults With Growth Hormone-Deficiency (GHD)
This study assesses the safety and tolerability of weekly TV-1106 compared to daily rhGH in adults with GHD who have previously been treated with rhGH.
- Trial name
- NCT02410356
- Testing
- TV-1106, dGH
- Where
- 50 sites in United States, Austria and 6 more
- Volunteers
- 34 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Without Aura
PACAP27 Headache Properties in Migraine Without Aura Patients
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a signaling molecule, localized in sensory and parasympathetic perivascular nerves fibres.
- Trial name
- NCT03471039
- Testing
- PACAP27, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Inappropriate ADH Syndrome
Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study
Empagliflozin (Jardiance)® is a sodium glucose co-transporter 2 (SGLT2)-Inhibitor, which is a new treatment option developed for patients with diabetes mellitus type 2.
- Trial name
- DIVE (NCT02729766)
- Testing
- Induced hypotonic hyponatremia - SIAD model, Empagliflozin 25mg Tbl
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Myoma
Topical Tranexamic Acid Plus Perivascular Vasopressin at the Time of Abdominal Myomectomy
In this study, the investigators will investigate the effectiveness of a topical tranexamic acid plus perivascular vasopressin compared with perivascular vasopressin alone for the reduction of blood loss at the time of myomectomy
- Trial name
- NCT03880045
- Testing
- Topical TA, vasopressin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Aswan University Hospital
Fibromyalgia, Chronic Low Back Pain
Mapping Stress and Pain Interactions (G072323N)
The over-arching goal of this observational (case-control, with a cross-sectional and longitudinal arm) study is to comprehensively map stress system (dys)function (including reactivity and recovery) in people with primary…
- Conditions
- Fibromyalgia, Chronic Low Back Pain, Subacute Low Back Pain
- Trial name
- STRAIN (NCT06892977)
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Ghent
Adult Growth Hormone Deficiency
A Safety, Pharmacokinetic and Pharmacodynamic Study of ACP-001 (TransCon hGH) in Adults With Growth Hormone Deficiency
This study investigates the safety, tolerability, pharmacokinetic profile (PK), and pharmacodynamic response (PD) of three different doses of ACP-001 given once-a-week compared to one dose-level of an approved daily human growth…
- Trial name
- NCT01247675
- Testing
- ACP-001 (TransCon hGH), Omnitrope
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 37 people
- Sponsor
- Ascendis Pharma A/S
Shock, Septic
Multimodal Vasopressor Strategy in Septic Shock
The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.
- Trial name
- NCT06155812
- Testing
- Simultaneous administration of vasopressors, Successive administration of vasopressors
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 79 people
- Sponsor
- University Medical Centre Maribor
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Central Diabetes Insipidus
Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls
The investigator hypothesize that low-dose MDMA (3,4-methylenedioxymethamphetamine) will produce a sufficiently strong oxytocin stimulation in healthy controls and no relevant increase in patients.
- Trial name
- OxyMAX (NCT06789705)
- Testing
- MDMA
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pituitary Adenoma
Semi-sitting Versus Supine Position in Endoscopic Skull Base Surgery
This study is to prospectively compare the standard supine (control group) and the semi-sitting position (head elevation of 30°; intervention group) in endoscopic endonasal pituitary surgery.
- Trial name
- PosESS (NCT04584866)
- Testing
- Endonasal endoscopic pituitary surgery in semi-sitting position, Endonasal endoscopic pituitary surgery in supine position
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University Hospital, Basel, Switzerland
Acromegaly
Somatostatin Analog Treatment of Acromegaly Before Pituitary Surgery : Comparison With Neurosurgery Alone
The aim of the study is to evaluate the interest of a six month pre-operative treatment with a long-acting somatostatin analog (Sandostatin LP) versus surgery alone in patients with a pituitary adenoma responsible for acromegaly.
- Trial name
- SAPORO (NCT01029275)
- Testing
- Pre-treatment with octreotide
- Where
- 13 sites in France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Rouen
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