Clinical trials: Placebo Analgesia
Nephrolithotomy, Percutaneous
ESP Block vs Control for Pain Control Following Percutaneous Nephrolithotomy
The purpose of this study is to investigate the use of the erector spinae (ESP) block in reducing the morphine milligram equivalent (MME) consumption post percutaneous nephrolithotomy. Objectives: 1.
- Trial name
- NCT05024344
- Testing
- Erector Spinae Plane Block, Ropivacaine 0.5% Injectable Solution, Dexamethasone
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Tennessee Medical Center
Osteoarthritis of the Hip
Fascia Iliaca Block for Post-Operative Pain Control After Total Hip Arthroplasty
This study evaluates post-operative pain management and narcotic consumption in patients receiving a fascia iliaca block with local anesthetic versus patients receiving fascia iliaca block with saline for total hip arthroplasty.
- Trial name
- NCT02299271
- Testing
- Ropivacaine, Saline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- The Christ Hospital
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Anxiety
Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery
Pain prior to surgery is of particular concern in patients undergoing total hip arthroplasty (THA) since it is the most important predictor of pain and poor function 2-3 years after surgery.
- Trial name
- RCT (NCT00762099)
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Sunnybrook Health Sciences Centre
Shoulder Pain, Post-operative Pain
Can Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain?
The purpose of this study is to compare the efficacy of parecoxib with placebo on the incidence and severity of postthoracotomy shoulder pain, the amount of analgesic requirement for relieving severity of postthoracotomy shoulder…
- Trial name
- NCT01288924
- Testing
- Parecoxib, Control
- Where
- 2 sites in Thailand
- Volunteers
- 160 people
- Sponsor
- Chiang Mai University
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Undergoing Hysterectomy
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing hysterectomy on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993226
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 115 people
- Sponsor
- Durect
Surgery
Analgesic Efficacy of Intravenous Dexmedetomidine for Supraclavicular Plexus Block
The goal of the study is to compare the duration of analgesia in patients undergoing forearm or hand surgery with a supraclavicular brachial plexus block, who receive either iv dexmedetomidine or placebo.
- Trial name
- TwoDex (NCT05389852)
- Testing
- Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Hôpital du Valais
Postoperative Pain, Ultrasound Guided Transmuscular Quadratus Lumborum Block
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Laparoscopic Hand-assisted Nephrectomy and Robot Assisted Partiel Nephrectomy
Patients with kidney cancer often undergo hand-assisted laparoscopic nephrectomy or Robot assisted partiel nephrectomy. The investigators performed a one-year retrospective study.
- Trial name
- NCT03571490
- Testing
- Ropivacaine, Saline
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Zealand University Hospital
Postoperative Pain, Third Molar
Effect of Oral Magnesium on Anesthesia and Postoperative Analgesia After Surgical Removal of the Lower Third Molars.
The operation of the lower third molars is one of the most common oral surgery procedures in the world. The surgery is mostly done in local anesthesia which makes the surgery as pleasant as possible for the patient.
- Conditions
- Postoperative Pain, Third Molar, Postoperative Complications
- Trial name
- NCT03398382
- Testing
- Magnesium tablet group, Magnesium lozenge group
- Where
- 2 sites in Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Daniel Jerković
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA).
- Trial name
- NCT00348010
- Testing
- Tramadol HCl ER
- Volunteers
- 245 people
- Sponsor
- Bausch Health Americas, Inc.
Pain
Peripheral KV7 Activation for Pain Relief
The goal of this clinical trial is to learn if the drug Flupirtine can safely lower pain when used in tiny amounts directly in the skin.
- Trial name
- NCT06971250
- Testing
- Capsaicin only (7.6 ng), Capsaicin + Flupirtine 0.5 µg, Capsaicin + Flupirtine 1.2 µg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stefan Heber
Contraception
Naproxen for Pain Control With Intrauterine Device Insertion
The purpose of this study is: 1. To evaluate whether 550 mg of naproxen sodium reduces pain scores with IUD insertion on a 0-10cm visual analogue scale compared to placebo (primary outcome). 2.
- Trial name
- NCT02388191
- Testing
- Naproxen sodium
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Burn
Instilled Lidocaine vs Placebo for Pain Management During Vacuum Assisted Closure (VAC) Dressing Changes
Patients will be randomized prospectively to one of two groups. One group will receive 5 mg/kg of 1% lidocaine, and the other will receive .9 normal saline, instilled into their VAC sponge ½ hour prior to VAC dressing change.
- Trial name
- NCT00585325
- Testing
- Instilled 1% Lidocaine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Myofacial Pain, Pelvic Pain
Lidocaine-prilocaine Cream as Analgesia for In-office Levator Muscle Trigger Point Injections
Levator muscle trigger point injections (TPI) are a commonly performed procedure in the office for treatment of pelvic pain related to pelvic floor muscles. The most common concern related to in-office TPI is pain.
- Trial name
- NCT07778043
- Testing
- Lidocaine-Prilocaine Cream 2.5-2.5%, Permeation-enhancing vanishing cream
- Volunteers
- 36 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Post-operative Pain, Cesarean Section
Post-operative Cesarean Trial of Pain Control
This study plans to learn more about postoperative pain management after cesarean deliveries (C-sections). As a part of standard of care, the Children's Hospital Colorado's Colorado Fetal Care Center (CFCC) follows the standard…
- Trial name
- NCT05131178
- Testing
- ON-Q Pump® with continuous infusion of bupivacaine, ON-Q Pump® with continuous infusion of saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Post Operative Pain, Acute, Laparoscopic Appendectomy
Intraoperative Intravenous Lidocaine for Pain After Laparoscopic Appendectomy
This randomized, double-blind, placebo-controlled clinical trial evaluated whether intraoperative intravenous lidocaine infusion improves postoperative analgesia and recovery in patients undergoing laparoscopic appendectomy.
- Trial name
- LIDO-APP (NCT07678385)
- Testing
- Lidocaine (drug)
- Where
- Venezuela
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetic Peripheral Neuropathy, Diabetic Neuralgia
Neuragen for Peripheral Diabetic Neuropathy
The purpose of this study is to determine if the use of Neuragen (a natural health product oil rubbed into the skin) is effective at reducing pain and improving the quality of life in people with diabetic peripheral neuropathy.
- Trial name
- NCT00861952
- Testing
- Neuragen, Mineral oil
- Where
- 2 sites in Canada
- Sponsor
- The Canadian College of Naturopathic Medicine
Postoperative Pain
Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection
Since VAT bears with it severe postopearive pain, and since ketamine has been shown to be an optimal analgesics adjuvant for postoperative pain, we wish to assess to effects of ketamie vs.
- Trial name
- NCT00822133
- Testing
- lidocaine, ketamine, non-active drug cream
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Analgesia
Analgesic Protocol With Gabapentin Dexmedetomidine For Postoperative Pain Managment
Assessment of quality of post mastectomy analgesic protocol of Gabapentin and Dexmedetomedine in a placebo-controlled study
- Trial name
- NCT04976374
- Testing
- Dexmedetomidine and Gabapentin, Saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute, Egypt