Clinical trials: Placebo Analgesia
Postoperative Pain
Acupuncture for Pain Control After Elective Caesarean Section
The study entitled "Acupuncture vs. placebo acupuncture and vs. standard therapy for pain control after elective caesarian section - a randomized controlled trial" aims to investigate whether acupuncture with indwelling fixed…
- Trial name
- ACUSEC (NCT02364167)
- Testing
- Standard therapy, Verum acupuncture
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University Medicine Greifswald
Central Neuropathic Pain in Multiple Sclerosis
Efficacy and Safety of the Pain Relieving Effect of Dronabinol in Central Neuropathic Pain Related to Multiple Sclerosis
The purpose of this study is to determine whether Dronabinol is effective and safe in relieving central neuropathic pain in multiple sclerosis patients.
- Trial name
- NCT00959218
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Bionorica Research GmbH
Blood Gas Analysis, Topical Analgesia
Evaluation of Analgesic Efficacy of Lidocaine and Diclofenac Spray in Radial Artery Blood Gas Sampling by Visual Analogue Scale and Perfusion Index
The aim of this clinical trial is to evaluate the analgesic efficacy of lidocaine and diclofenac sprays to be administered before the procedure in cases admitted to the emergency department and requiring radial artery blood gas…
- Trial name
- NCT06918340
- Testing
- Diclofenac, Lidocaine spray
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Invasive Ventilation, Infant Pain
Dexmedetomidine for Invasive Ventilation In the NEOnate
Despite the increasing use of non-invasive ventilation, a large majority of premature neonates still receive invasive ventilation during their NICU (neonatal intensive care unit) stay.
- Conditions
- Invasive Ventilation, Infant Pain, Infant Discomfort, Infant Neurodevelopment
- Trial name
- NCT07493785
- Testing
- Dexmedetomidine Injectable Solution, Glucose 5% Injectable Solution
- Where
- 12 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Pain, Postoperative, Abdominoplasty
Efficacy and Safety Study of Postsurgical Analgesia With INL-001 in Abdominoplasty
This is a multicenter, randomized, double-blind, placebo-controlled efficacy and safety study of the INL-001 (bupivacaine HCl) implant, at 300 mg, in patients following abdominoplasty to evaluate postoperative analgesia.
- Trial name
- NCT04785625
- Testing
- Bupivacaine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 366 people
- Sponsor
- Innocoll
Postoperative Pain
Bunionectomy Study for Postoperative Analgesia (EPOCH 1)
This is a Phase 3, randomized, double-blind, saline placebo- and active-controlled, multicenter study to evaluate the analgesic efficacy and safety of HTX 011 administered via local administration into the surgical site in…
- Trial name
- NCT03295721
- Testing
- HTX-011, Bupivacaine HCl, Luer-lock applicator
- Where
- 15 sites in United States
- Volunteers
- 412 people
- Sponsor
- Heron Therapeutics
Critical Illness, Pain
Treatment of Procedural Pain Associated With Turning in Patients With Mechanical Ventilation
Background: Few studies have addressed the situation of procedural pain and the use of preemptive analgesia for turning in patients under mechanical ventilation.
- Trial name
- NCT01950000
- Testing
- Fentanyl
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pain, Postoperative
Safety and Efficacy of Intranasal Ketamine for the Treatment of Postoperative Dental Pain
Once patients' postoperative pain intensity reaches a moderate-to-severe level, they are randomized to receive intranasal ketamine or placebo.
- Trial name
- NCT00488787
- Testing
- intranasal ketamine
- Volunteers
- 40 people
- Sponsor
- Javelin Pharmaceuticals
Analgesia
Improving Quality of Bier Block
Intravenous regional anesthesia is one of the well-known techniques of regional anesthesia for short surgical operations on the upper and lower limbs. It was first introduced back in 1908.
- Trial name
- NCT04393610
- Testing
- Lidocaine, Magnesium Sulphate, Fentanyl
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
Anesthesia
Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia
The research will be conducted between March 2021 and June 2023. All patients scheduled electively for one of four surgeries (Laparoscopic Cholecystectomy, Submucosal resection, Breast lumpectomy, and median laparotomy) at that…
- Trial name
- NCT05389813
- Testing
- Oxycodone 20 Mg Oral Tablet, Pregabalin 150mg, Multivitamin with Minerals
- Where
- Palestinian Territories
- Volunteers
- 150 people
- Sponsor
- An-Najah National University
Acute Pain
XG005 for Pain Control in Subjects Undergoing Bunionectomy
This study will evaluate the safety, efficacy, and PK of low dose (750 mg) and high-dose (1250 mg) XG005 oral tablets compared with placebo in subjects undergoing bunionectomy.
- Trial name
- NCT06017999
- Testing
- XG005 tablet
- Where
- 8 sites in United States
- Volunteers
- 450 people
- Sponsor
- Xgene Pharmaceutical Group
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Chronic Pain, Low Back Pain
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain
The primary objective of the study is to determine the analgesic efficacy and safety of ALO-02 extended-release capsules, when compared to placebo, in subjects with moderate to severe chronic low back pain.
- Conditions
- Chronic Pain, Low Back Pain, Analgesia
- Trial name
- NCT01571362
- Testing
- ALO-02
- Where
- 52 sites in United States
- Volunteers
- 410 people
- Sponsor
- Pfizer
Spondylolisthesis, Lumbar Disc Herniation
Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery
Rationale: Lumbar spine surgery is associated with high postoperative pain scores and analgesic use, despite use of multimodal analgesia.
- Conditions
- Spondylolisthesis, Lumbar Disc Herniation, Lumbar Spinal Stenosis, Lumbar Disc Disease
- Trial name
- RCT-ESPB (NCT05345249)
- Testing
- Ropivacaine Hydrochloride Injection, Sodium chloride
- Where
- Netherlands
- Volunteers
- 76 people
- Sponsor
- Ilse van de Wijgert
Pain, Cancer
A Phase 2a, Proof-of-Concept Study of GIC-1001 in the Management of Visceral Pain During Sedation-Free, Full Colonoscopy
GIC-1001 is a novel, orally-administered, colonic analgesic drug developed as an alternative to i.v. sedation during full colonoscopy.
- Conditions
- Pain, Cancer, Colonic Diseases
- Trial name
- NCT01926444
- Testing
- GIC-1001
- Where
- 15 sites in United States, Canada
- Volunteers
- 308 people
- Sponsor
- gicare Pharma Inc.
Cataract
A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)
The primary purpose of the study is to evaluate the efficacy and safety of MELT-300 (Midazolam and Ketamine Sublingual Tablets) and the contribution of midazolam and ketamine components to sedation and during the surgery or…
- Trial name
- NCT05133518
- Testing
- MELT-300, Midazolam alone, Ketamine alone
- Where
- 3 sites in United States
- Volunteers
- 338 people
- Sponsor
- Melt Pharmaceuticals
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended-release Tramadol Versus Placebo in the Treatment of Chronic Low Back Pain
The purpose of this study is to compare the analgesic efficacy of oral, once-daily tramadol ER 300 mg and 200 mg to placebo in patients with moderate to severe chronic low back pain requiring daily analgesic treatment.
- Trial name
- NCT00347724
- Testing
- Tramadol HCl ER
- Volunteers
- 600 people
- Sponsor
- Bausch Health Americas, Inc.
Pain, Postoperative
Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery
This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill).
- Trial name
- NCT07720791
- Testing
- Acetaminophen
- Volunteers
- 1,504 people
- Sponsor
- Konya City Hospital
Pain Control
Efficacy of TAP Block in Cesarean Section Patients
TAP Block done with 2 different concentrations of bupivacaine and placebo
- Trial name
- NCT03493828
- Testing
- TAP block using Bupivacaine 0.5%, TAP block using Bupivacaine 0.25%, TAP block using Normal Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Pain, Postoperative
Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
- Trial name
- NCT02272660
- Testing
- Parecoxib sodium, Normal saline injection
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital