Clinical trials: Placebo Response
COVID-19
Brequinar Combined With Dipyridamole in Patients With Mild to Moderate COVID-19
A Phase 2 multi-center, assessor-blind, randomized study to assess the safety, tolerability, and antiviral activity of brequinar in combination with dipyridamole.
- Trial name
- CCBCRISIS04 (NCT05166876)
- Testing
- Brequinar Sodium, Dipyridamole 75 MG
- Where
- 7 sites in India
- Volunteers
- 26 people
- Sponsor
- Clear Creek Bio, Inc.
Septic Shock
A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic Response
The FLUDRO-SHOCK trial is a large international randomised controlled double-blinded study aiming to improve treatment for people with septic shock, a life-threatening condition caused by severe infection.
- Trial name
- FLUDRO-SHOCK (NCT07898462)
- Testing
- Fludrocortisone 50 mcg daily, Fludrocortisone 100 mcg daily
- Where
- 8 sites in Australia
- Volunteers
- 2,200 people
- Sponsor
- The George Institute
Primary Biliary Cirrhosis (PBC)
Study to Evaluate the Effects of Two Doses of Seladelpar (MBX-8025) in Subjects With Primary Biliary Cirrhosis (PBC)
The primary objective of this study is to evaluate the effect of seladelpar (MBX-8025) on alkaline phosphatase (AP) levels in participants with primary biliary cirrhosis (PBC).
- Trial name
- NCT02609048
- Testing
- Experimental: Seladelpar 50 mg, Experimental: Seladelpar / MBX-8025 200 mg
- Where
- 49 sites in United States, Canada and 3 more
- Volunteers
- 41 people
- Sponsor
- Gilead Sciences
Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD)
The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The goal of this clinical trial is to learn if daily supplementation with Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), can reduce…
- Conditions
- Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD), MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD
- Trial name
- PEC-MASLD (NCT07093346)
- Testing
- Pectin, Cocoa Powder, Magnetic Resonance Imaging with Contrast
- Where
- 3 sites in United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Rheumatoid Arthritis
A Study Evaluating the Efficacy and Safety of CKD-506 in Adult Subjects With Moderate-to-Severe Rheumatoid Arthritis and Inadequate Response to Methotrexate
The primary objective of this study is to evaluate the effects of CKD-506 on signs and symptoms of RA in subjects with moderate-to-severe RA who are inadequate responders to methotrexate.
- Trial name
- NCT04204603
- Testing
- CKD-506
- Where
- 38 sites in Czechia, Georgia and 3 more
- Volunteers
- 122 people
- Sponsor
- Chong Kun Dang Pharmaceutical
ARDS
Protective Effect of Sivelestat Sodium on ARDS in Patients With Sepsis
Sivelestat sodium has been approved for use in patients with SIRS and ALI, but whether it can protect patients with sepsis from developing ARDS remains unknown.The aim of this study was to determine whether sivelestat sodium has…
- Trial name
- NCT04973670
- Testing
- Sivelestat sodium
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Southeast University, China
Beetroot Juice, Placebo
Dose-Response Effects of Beetroot Juice on Neuromuscular Performance in the Bench Press
Beetroot juice is rich in dietary nitrate, a compound that may improve muscle function and exercise performance. However, the effects of different nitrate doses on upper-body strength and muscular endurance are lees explored.
- Trial name
- BEET_BP (NCT07911072)
- Testing
- Nitrate-Rich Beetroot Juice
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
Acute Kidney Injury Due to Sepsis
Pharmacokinetics and Safety of TIN816 in Patients With Sepsis-associated Acute Kidney Injury
The purpose of this study was to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) profile and to evaluate the safety and tolerability of TIN816 in hospitalized adult participants in an intensive care setting with a…
- Trial name
- NCT05507437
- Testing
- TIN816 70 mg lyophilisate powder
- Where
- 7 sites in Belgium, France and 3 more
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Hemodynamic Stability Post Intubation in Laryngoscopy Surgery
Intravenous Lignocaine vs Placebo
To assess the mean hemodynamic responses post-intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation in patients undergoing laryngoscopy surgery
- Trial name
- NCT03787069
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indus Hospital and Health Network
Dysglycemia
A Study to Investigate the Effect of MCE on Glucose and Insulin Responses in Healthy Males
Maize Cob Extract (MCE) is intended to be used as a bulking agent in food. The purpose of this study is to determine the glycaemic and insulinemic response of MCE consumed in isolation compared to glucose; the glycaemic and…
- Trial name
- NCT04296045
- Testing
- MCE, Glucose
- Where
- Ireland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cambridge Glycoscience
Infection Associated With Catheter, Bacteremia
Safety and Efficacy Study of Ethanol Locking to Prevent Central Line Infection in Premature Neonates
Appropriate delivery of adequate nutrition and medications in premature infants often requires central venous access in the form of a special IV called a PICC (peripherally inserted central catheter).
- Conditions
- Infection Associated With Catheter, Bacteremia, Sepsis
- Trial name
- NCT01365312
- Testing
- Ethanol lock, Heparinized saline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- East Carolina University
Septic Shock
Acetyl-L-Carnitine in the Treatment of Septic Shock
This placebo-controlled study investigates acetyl-L-carnitine in the treatment of septic shock requiring vasopressors.
- Trial name
- ALC (NCT00592488)
- Testing
- Acetyl-L-Carnitine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Major Depressive Disorder
Study to Evaluate the Effect and Safety of Quetiapine Extended Release (XR) (FK949E) in Major Depressive Disorder
In this study, quetiapine XR or placebo will be administered orally for 6 weeks to major depressive disorder patients with lack of response to existing antidepressants, with the aim of evaluating the efficacy of quetiapine XR and…
- Trial name
- NCT01725282
- Testing
- quetiapine extended release (XR)
- Where
- 3 sites in Japan
- Volunteers
- 172 people
- Sponsor
- Astellas Pharma Inc
Rheumatoid Arthritis
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
The purpose of this study was to assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib versus placebo and versus an active comparator, adalimumab, in adults with with moderately to…
- Trial name
- SELECT-COMPARE (NCT02629159)
- Testing
- Adalimumab, Upadacitinib
- Where
- 370 sites in United States, Argentina and 42 more
- Volunteers
- 1,629 people
- Sponsor
- AbbVie
Rotator Cuff Related Shoulder Pain, Shoulder Pain
Contextually Enhanced Exercise Programs for Rotator Cuff-Related Shoulder Pain
The goal of this clinical trial is to learn whether adding personalized contextual factors to an exercise program can improve pain and function in people with rotator cuff-related shoulder pain.
- Conditions
- Rotator Cuff Related Shoulder Pain, Shoulder Pain, Rotator Cuff Injuries
- Trial name
- CONTEXT-RCRSP (NCT07428070)
- Testing
- Contextually Fixed Exercise Program, Contextually Enriched Personalized Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Istanbul Nisantasi University
Ulcerative Colitis
The Role of Gut Bacteria in the Immune Response to Vaccination in Patients With Ulcerative Colitis
Patients with the inflammatory bowel disease ulcerative colitis (UC) are a high-risk group encouraged to get vaccinated against seasonal influenza. It is also known that UC patients may have an altered gut microbiota.
- Trial name
- NCT06504784
- Testing
- Dietary Fiber Mixture
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Chronic Plaque-type Psoriasis
A Dose Ranging Study of AIN457 in Patients With Moderate to Severe Chronic Plaque-type Psoriasis
The purpose of the study is to determine whether, in patients with moderate to severe plaque-type psoriasis, AIN457 administered subcutaneously reduces the severity of psoriasis symptoms and the extent to which the patient's body…
- Trial name
- NCT01071252
- Testing
- AIN457
- Where
- 19 sites in United States, Canada and 4 more
- Volunteers
- 125 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
Impact of Dietary Flavanols on Microvascular Function in Young Females During Mental Stress
The aim of this project is to examine whether flavonoids, which are small molecules naturally present in cocoa, as well as fruits and vegetables such as berries, tea, citrus fruits, apple (typically responsible for giving these…
- Trial name
- NCT07864545
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Hepatitis B
Safety and Efficacy Study of L-FMAU in Chronic HBV Patients of L-FMAU-201 Placebo Group
The purpose of this study is to evaluate the safety and antiviral activity of clevudine 30 mg QD for treatment of longer period (24 weeks) in patients chronically infected with HBV.
- Trial name
- NCT00313261
- Testing
- Clevudine
- Where
- 7 sites in South Korea
- Sponsor
- Bukwang Pharmaceutical
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