Clinical trials: Placebo-Post
Postoperative Ileus
Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery
The purpose of this study is to determine whether TZP-101 is effective in the management of post operative ileus in subjects undergoing major open abdominal surgery (i.e. partial large bowel resection).
- Trial name
- NCT00617552
- Testing
- 5% dextrose in water, TZP-101
- Where
- 27 sites in United States, India and 1 more
- Volunteers
- 267 people
- Sponsor
- Tranzyme, Inc.
Type 2 Diabetes Mellitus
A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test
The study has a randomized, double-blind, placebo-controlled, double dummy and eight-way cross-over design. Males with T2DM on a stable metformin monotherapy will be screened for participation in the study.
- Trial name
- DXM2 (NCT01936025)
- Testing
- Dextromethorphan, Sitagliptin
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Pain, Postoperative, Abdominoplasty
Efficacy and Safety Study of Postsurgical Analgesia With INL-001 in Abdominoplasty
This is a multicenter, randomized, double-blind, placebo-controlled efficacy and safety study of the INL-001 (bupivacaine HCl) implant, at 300 mg, in patients following abdominoplasty to evaluate postoperative analgesia.
- Trial name
- NCT04785625
- Testing
- Bupivacaine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 366 people
- Sponsor
- Innocoll
Long COVID
Study of LAU-7b for the Treatment of Long COVID in Adults
ESSOR is a double-blind, placebo-controlled study of the orally-administered antiviral and inflammation-controlling LAU-7b for the treatment of adults with Long COVID and moderate to severe symptoms.
- Trial name
- ESSOR (NCT05999435)
- Testing
- LAU-7b for 3 cycles
- Where
- 5 sites in Canada
- Volunteers
- 272 people
- Sponsor
- Laurent Pharmaceuticals Inc.
Pain, Postoperative, Hernia, Inguinal
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
The purpose of this study is to test whether pregabalin added to the standard of care with dosing starting preoperatively and continuing for 1 week post surgery will decrease the intensity of acute post-operative pain following…
- Trial name
- NCT00551135
- Testing
- Pregabalin
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 425 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Traumatic Brain Injury
A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.
A Randomized, Double Blind, Placebo Controlled, Phase 2 Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple I.V.
- Trial name
- NCT00735085
- Testing
- SLV334
- Where
- 14 sites in United States, Israel and 2 more
- Volunteers
- 57 people
- Sponsor
- Abbott Products
Gastro-Intestinal Stromal Tumour
Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence
The objective is to compare the efficacy and safety of masitinib at 4.5 mg/kg/day to placebo in the treatment of patients with localized, primary gastrointestinal stromal tumor (GIST) after complete surgery and with high risk of…
- Trial name
- NCT02009423
- Testing
- Masitinib
- Volunteers
- 7 people
- Sponsor
- AB Science
Post-traumatic Stress Disorder, Post Traumatic Stress Disorder
A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder
This trial is comprised of a 4-week randomized, double-blind, placebo-controlled treatment period followed by an optional 8-week open-label extension (OLE) period.
- Conditions
- Post-traumatic Stress Disorder, Post Traumatic Stress Disorder, Stress Disorder, Stress Disorders, Post-Traumatic
- Trial name
- NCT05260541
- Testing
- 60 mg PRAX-114 or 40 mg PRAX-114, 40 mg PRAX-114
- Where
- 17 sites in United States
- Volunteers
- 11 people
- Sponsor
- Praxis Precision Medicines
Post-Operative Pain
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery
The purpose of this study is to compare the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg to the Placebo Sufentanil NanoTab PCA System for the management of acute moderate to severe post-operative pain after…
- Trial name
- NCT01539642
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 12 sites in United States
- Volunteers
- 172 people
- Sponsor
- Talphera, Inc
Healthy Participants
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD3974 in Healthy Participants
The purpose of this study is to assess the safety and tolerability of AZD3974 and characterize the pharmacokinetics (PK) of AZD3974 following oral administration to healthy participants, including participants of Japanese and…
- Trial name
- NCT07290283
- Testing
- AZD3974
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study in Healthy Volunteers to Assess the Tolerability and Blood Levels of a Single Dose of AZD7687
This is a Phase I, first time in human, randomised, blinded, placebo-controlled, single ascending dose study in healthy male volunteers conducted at a single centre.
- Trial name
- NCT01046357
- Testing
- AZD7687
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Safety, Pharmacodynamics, and Pharmacokinetics of BIBT 1011 BS in Healthy Subjects
A study to assess safety, pharmacokinetics and the effect of BIBT 986 BS, given as BIBT 1011 BS, on coagulation parameters.
- Trial name
- NCT02182037
- Testing
- Single rising doses of BIBT 1011 BS
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
COVID-19
Study in Adults to Assess the Safety and Efficacy of Inhaled IBIO123, for Post-exposure Prophylaxis of COVID-19
This is a Phase 2, randomized, double-blind, multicentre, placebo-controlled study in adults to assess the safety and efficacy of inhaled IBIO123, for post-exposure prophylaxis of COVID-19.
- Trial name
- NCT05639166
- Testing
- IBIO123
- Where
- 5 sites in South Africa, Ukraine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Immune Biosolutions Inc
Healthy
A Multiple Increasing Dose Safety and Tolerability Study After Inhalation Administration of BIIX 1 XX in Healthy Male Volunteers
The objective of the present study is to obtain information about the safety and tolerability of multiple increasing doses of BIIX 1 XX and to obtain preliminary pharmacokinetic data
- Trial name
- NCT02198313
- Testing
- BIIX 1 XX - D1, BIIX 1 XX - D2, BIIX 1 XX - D3
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Postherpetic Neuralgia
Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Post-Herpetic Neuralgia
The primary objective of the study is to assess the efficacy of eslicarbazepine acetate (ESL) as therapy for patients with post-herpetic neuralgia.
- Trial name
- NCT00981227
- Testing
- Eslicarbazepine acetate
- Volunteers
- 567 people
- Sponsor
- Bial - Portela C S.A.
Post-acute COVID-19 Syndrome
Сlinical Trial of Efficacy and Safety of Prospekta in the Treatment of Post-COVID-19 Asthenia.
The multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial. The objective of this study is to evaluate the efficacy and safety of Prospekta in the treatment of asthenia in patients after the…
- Trial name
- NCT05074888
- Testing
- Prospekta
- Where
- 32 sites in Russia
- Volunteers
- 676 people
- Sponsor
- Materia Medica Holding
Type 2 Diabetes Mellitus
Dextromethorphan, Amantadine and Glucose Homeostasis in Diabetes Subjects
The purpose of this trial is to demonstrate that dextromethorphan (DXM) and amantadine compared to placebo exert blood glucose (BG) lowering effects following an oral glucose tolerance test (OGTT) in male subjects with T2DM.
- Trial name
- DXM/AMT (NCT01441986)
- Testing
- Dextromethorphan hydrobromide, Amantadine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Chronic Kidney Disease, Hypertension
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
Researchers are looking for a better way to treat people who have chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly.
- Trial name
- NCT05491642
- Testing
- BAY3283142
- Where
- 4 sites in Bulgaria, Germany
- Volunteers
- 56 people
- Sponsor
- Bayer
Abdominoplasty
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in the Management of Acute Postoperative Pain
Evaluate the Safety and Pharmacokinetic Profile of CPL-01 in patients after mini-abdominoplasty
- Trial name
- NCT04182880
- Testing
- CPL-01
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cali Pharmaceuticals LLC
Neoplasms, Prostate, Prostate Cancer After a Radical Treatment
ARTS - AVODART After Radical Therapy For Prostate Cancer Study
ARI109924 will be a 2-year, multicentre, randomised, double-blind, placebo-controlled trial assessing the efficacy and safety of dutasteride in extending time to prostate specific antigen (PSA) doubling in men who have been…
- Trial name
- ARTS (NCT00558363)
- Testing
- Avodart
- Where
- 66 sites in Estonia, Finland and 7 more
- Volunteers
- 294 people
- Sponsor
- GlaxoSmithKline
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