Clinical trials: Placebo-Post
Constipation
Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients
Constipation is a known complication of the postoperative period after spinal surgery, where prescription pain medicines called opioids are traditionally used in high doses for the treatment of surgery-related pain.
- Trial name
- NCT02946580
- Testing
- MOVANTIK™ (naloxegol), Sugar Pill
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Massachusetts General Hospital
Stomach Cancer
Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic Gastrectomy
"Mosapride citrate is a 5-hydroxytryptamine 4 receptor agonist, and is widely used as an agent to increase intestinal motility. Mosapride citrate has been demonstrated in in vitro and in vivo studies to increase both gastric and…
- Trial name
- NCT04493125
- Testing
- Mosapride citrate
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Gangnam Severance Hospital
Post-Extubation Laryngeal Edema
Prevention of Post-Extubation Laryngeal Edema With Intravenous Corticosteroids
Tracheal intubation is a frequent procedure in intensive care units (ICU). Post-extubation laryngeal edema is a frequent complication with potential morbidity and mortality, and may lead to urgent tracheal re-intubation.
- Trial name
- NCT00199576
- Testing
- Methylprednisolone
- Where
- 15 sites in France
- Volunteers
- 670 people
- Sponsor
- University Hospital, Limoges
Acute Pain
Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty
The purpose of this study was to evaluate the efficacy and safety of Suzetrigine (SUZ) in treating acute pain after an abdominoplasty.
- Trial name
- NCT05558410
- Testing
- Suzetrigine (SUZ), HB/APAP
- Where
- 12 sites in United States
- Volunteers
- 1,118 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Postoperative Pain
The Effect of Intravenous Lidocaine on Pain After Thyroidectomy
This prospective randomized study aims to evaluate the effectiveness of intravenous lidocaine injection on the relief of pain in patients undergoing thyroidectomy.
- Trial name
- NCT01608360
- Testing
- Intravenous lidocaine injection, Intravenous normal saline injection
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Chung-Ang University Hospital
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Post Hallux Valgus Repair Pain
TRAUMEEL S in Reducing Pain After Correction of Hallux Valgus-Clinical Trial
Hallux valgus is a common deformity of the big toe, defined as medial deflection of the first metatarsal bone along with lateral deflection of the first toe.
- Trial name
- NCT00279513
- Testing
- Traumeel S
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Post-menopausal Period
Pharmacokinetics, Pharmacodinamic and Safety of Testosterone Gel 1%
This is a Phase I, open-label, parallel trial to evaluate Pharmacokinetics, Pharmacodynamics and Safety of Testosterone gel 1% for topic usage in post-menopausal women, for 28 days
- Trial name
- NCT02667561
- Testing
- Testosterone gel 1% 2.2 mg, Testosterone gel 1% 4.4 mg, Testosterone gel 1% 8.8 mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Functional Dyspepsia
Functional Dyspepsia: Validation of the Leuven Postprandial Distress Scale (LPDS) in a Placebo-controlled Trial
No instrument is available for the assessment of the symptoms in patients suffering from functional dyspepsia - postprandial distress syndrome patients - PDS. Indeed PDS is an unmet clinical need in drug development.
- Trial name
- NCT04464369
- Testing
- itopride
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Total Knee Arthroplasty
Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion
Total knee replacement is often associated with severe postoperative pain, especially in the first 24 hours. Patient controlled analgesia (PCA) and continuous femoral block with PCA are commonly used to treat postoperative pain…
- Trial name
- NCT00616850
- Testing
- Continuous femoral catheter block, Lidocaine, Preservative free normal saline
- Where
- United States
- Sponsor
- Loma Linda University
Pruritus in Patients With Atopic Dermatitis
Safety and Efficacy of DNK333 in Atopic Dermatitis Patients
This study will assess the safety and efficacy of DNK333 in patients with atopic dermatitis suffering from pruritus, who require systemic treatment of the disease.
- Trial name
- NCT01033097
- Testing
- DNK333 5 mg, DNK333 25 mg, DNK333 100 mg
- Where
- 5 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Novartis Pharmaceuticals
Neuropathic Pain, Postmastectomy Pain
Symptom Management After Breast Cancer Surgery
This trial is part of a larger, longitudinal study of symptoms that occur in the breast surgical scar area and/or ipsilateral arm following breast cancer surgery.
- Trial name
- NCT00686127
- Testing
- Lidoderm patch
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease
REVASC is a randomized, double-blind, placebo-controlled study which will involve 150 patients with chronic bronchitis and COPD diagnosed cardiovascular disease.
- Trial name
- REVASC (NCT01595750)
- Testing
- Roflumilast 500
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Spanish Research Center for Respiratory Diseases
Metastatic Breast Cancer
A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi
This study was a multicenter, randomized, double-blind, placebo-controlled Phase III study to determine the efficacy and safety of treatment with Buparlisib plus Fulvestrant vs.
- Trial name
- BELLE-3 (NCT01633060)
- Testing
- Fulvestrant, BKM120
- Where
- 197 sites in United States, Argentina and 20 more
- Volunteers
- 432 people
- Sponsor
- Novartis Pharmaceuticals
Pain, Postoperative, Dental Pain
A Study of Acetaminophen for Post Surgical Dental Pain
To assess the safety, tolerability, analgesic, efficacy and pharmacokinetics of high dose acetaminophen relative to placebo and low dose acetaminophen relative to placebo over a 24 hour period in patient experiencing moderate to…
- Trial name
- NCT04018612
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Postpartum Hemorrhage
Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women at Higher Risk
Heavy bleeding after childbirth, known as a postpartum haemorrhage (PPH), causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a lifesaving treatment for women with PPH.
- Trial name
- I'M-WOMAN (NCT05562609)
- Testing
- Tranexamic acid
- Where
- Tanzania
- Volunteers
- 40,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Covid19
Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise
This is a Phase 2a randomized, placebo-controlled study designed to investigate the efficacy, safety and tolerability of COVI-MSC in treating post COVID-19 "long haul" pulmonary compromise.
- Trial name
- BR (NCT04992247)
- Testing
- COVI-MSC
- Sponsor
- Sorrento Therapeutics, Inc.
Impotence
To Determine How Different Doses of Tadalafil Work on Getting and Keeping an Erection 26 or 36 Hours After Taking
Study to see how effective different doses of tadalafil are for getting and keeping an erection when sex is attempted after a certain number of hours.
- Trial name
- NCT00547508
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 485 people
- Sponsor
- Eli Lilly and Company
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
The Danish Out-of-Hospital Cardiac Arrest Study
After resuscitation from Out-of-Hospital Cardiac Arrest (OHCA) patients experience Post Cardiac Arrest Syndrome due to ischemia and reperfusion injury.
- Trial name
- DANOHCA (NCT05895838)
- Testing
- Dexamethasone, Backrest elevation, Early wakeup call
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Hassager
Prevention of Venous Thromboembolism
Rivaroxaban or Placebo for Extended Antithrombotic Prophylaxis After Laparoscopic Surgery for Colorectal Cancer.
Rivaroxaban or placebo for extended antithrombotic prophylaxis after laparoscopic surgery for colorectal cancer: a randomized, double blind, placebo-controlled study.
- Trial name
- PRO-LAPSII (NCT03055026)
- Testing
- Rivaroxaban
- Where
- 17 sites in Italy
- Volunteers
- 582 people
- Sponsor
- Fadoi Foundation, Italy
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