Clinical trials: Placebo-Post
Post-Dural Puncture Headache, Ganglion Sphenopalatine Block
The Effect of Ganglion Sphenopalatine Block (GSP-block) Follow-Up
The purpose of this study is to evaluate the long term effects of the ganglion sphenopalatine block (GSP block) on postdural puncture headache.
- Trial name
- GSP-FOLLOW (NCT05301387)
- Testing
- Ganglion Sphenopalatine Block
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Chronic Obstructive Pulmonary Disease
A Phase 2a Study to Assess Safety, Daily Symptoms, PK, and Biomarkers of YPL-001 in COPD Patients
This is a Phase 2a, proof-of-concept, multicenter, randomized, double-blind, double dummy, 3-treatment, parallel study, with low and high YPL 001 doses (low dose and high dose twice daily [BID]) and a placebo control in moderate…
- Trial name
- NCT02272634
- Testing
- YPL-001 80 mg, YPL-001 160 mg
- Where
- 4 sites in United States
- Volunteers
- 61 people
- Sponsor
- Yungjin Pharm. Co., Ltd.
Autism Spectrum Disorder
Intranasal Oxytocin in Youth With Autism
Growing evidence demonstrates the critical contribution of the neuropeptide oxytocin in the development and maintenance of autism, due to its role in social behaviour and learning processes.
- Trial name
- NCT05934812
- Testing
- Oxytocin nasal spray
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Oslo University Hospital
Post Operative Pain
Transversus Abdominis Plane Blocks With Abdominoplasty
Comparing morphine consumption and recovery with two different TAP block techniques after abdominoplasty.
- Trial name
- TAPA (NCT01278264)
- Testing
- Ropivacaine 0.25%, 0.5 ml/kg
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinique Saint-Jean, Bruxelles
Postoperative Pain
Intravenous Dexamethasone as an Adjuvant to Dexmedetomidine After Superior Trunk Block for Arthroscopic Shoulder Surgery
This study aims to evaluate whether adding intravenous dexamethasone to standard intravenous dexmedetomidine improves pain control after shoulder arthroscopy performed under a superior trunk block.
- Trial name
- STB-DEXA (NCT07525934)
- Testing
- Dexamethasone, Dexmedetomidine, Sodium Chloride 0.9%
- Volunteers
- 70 people
- Sponsor
- Recep Karakaşoğlu
Parkinson Disease
Continued Efficacy of Apomorphine After Previous Exposure of at Least Three Months
The objective of this study was to measure the continued efficacy of apomorphine after previous exposure of at least three months duration.
- Trial name
- NCT00200512
- Testing
- apomorphine HCl injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Postoperative Pain, Tonsillectomy
Ketamine Gargle for Pain After Pediatric Tonsillectomy
Post-tonsillectomy pain in children is a common and clinically significant problem that may lead to poor oral intake, dehydration, and delayed recovery.
- Conditions
- Postoperative Pain, Tonsillectomy, Adenotonsillectomy
- Trial name
- KET-TONSIL (NCT07558044)
- Testing
- Ketamine Hydrochloride in saline, Normal Saline (0.9% NaCl)
- Where
- Venezuela
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Depressive Disorder, Major Depression
A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder
The purpose of the study is to assess whether treatment with SR58611A can prevent relapse of depressive symptoms in patients with major depressive disorder.
- Trial name
- CALYPSO (NCT00345098)
- Testing
- SR58611A
- Where
- 13 sites in Argentina, Bulgaria and 11 more
- Volunteers
- 704 people
- Sponsor
- Sanofi
Healthy Subjects
UP-818-CC Injection in Healthy Chinese Subjects
The objectives of this study are to evaluate the safety, tolerability and pharmacokinetic characteristics in healthy Chinese volunteers after single and multiple dose of intravenous infusion of UP-818-CC.
- Trial name
- UP-818-CC (NCT07355621)
- Testing
- UP-818-CC injection
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- EnliTISA (Shanghai) Pharmaceutical Co., Ltd.
Long COVID, Long Covid19
RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine)
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06305806
- Testing
- Ivabradine, Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Kanecia Obie Zimmerman
Athlete
The Effect of Inspiratory Muscle Warm-up on Decreased Diffusing Capacity for Carbon Monoxide After Maximal Exercise in Athletes
This study aims to examine the effects of inspiratory muscle warm-up (IMW) on the gas exchange capacity of the lungs (DLCO) and its potential contribution to recovery and athletic performance in elite athletes from various…
- Trial name
- NCT06751511
- Testing
- General warm-up, Inspiratory muscle warm-up (%40 IMW)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Emre Karaduman
Brain Swelling, Large Hemispheric Infarction
A Trial of HRS8179 on Brain Swelling After Large Hemispheric Infarction
The primary objective is to explore if HRS8179 could improve midline shift at 72 hours (or at time of decompressive craniectomy or comfort measures only, if earlier) in participants with large hemispheric infarction.
- Trial name
- NCT05690711
- Testing
- HRS8179
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Post-stroke Spasticity of the Upper Limb
Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the upper limb are effective in treating spasticity in patients after stroke.
- Trial name
- PURE (NCT01392300)
- Testing
- IncobotulinumtoxinA (400 Units)
- Where
- 47 sites in United States, Czechia and 5 more
- Volunteers
- 317 people
- Sponsor
- Merz Pharmaceuticals GmbH
Athletic Performance, Muscle Fatigue
The Effect of Hydrogen Rich Water Intake on Acute Body Response and Following Recovery After 5 km Run in Untrained Men
The aim of this randomized, double blinded, placebo controlled cross-over study is to evaluate the effect of hydrogen rich water intake on running performance, physiological and biochemical variables during endurance exercise and…
- Conditions
- Athletic Performance, Muscle Fatigue, Oxidative Stress
- Trial name
- NCT05862987
- Testing
- Hydrogen rich water
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Palacky University
Post-Traumatic Stress Disorder
A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder
This study is open to people aged 18 to 65 who have post-traumatic stress disorder. The purpose of this study is to find out whether a medicine called BI 1358894 improves symptoms in people with post-traumatic stress disorder.
- Trial name
- NCT05103657
- Testing
- BI 1358894
- Where
- 61 sites in United States, Croatia and 6 more
- Volunteers
- 318 people
- Sponsor
- Boehringer Ingelheim
Post-surgical Pain
Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection in patients undergoing unilateral total knee arthroplasty.
- Trial name
- NCT02807428
- Testing
- AYX1 Injection 660 mg/6 mL
- Where
- 9 sites in United States
- Volunteers
- 210 people
- Sponsor
- Adynxx, Inc.
Blepharoplasty, Upper Eyelid Blepharoplasty
Efficacy of Arnica D1 Ointment After Upper Blepharoplasty
Arnica ointment is currently used in homeopathic preparations for strains and bruises. In the field of plastic surgery, some surgeons advise patients undergoing blepharoplasty to use Arnica in order to prevent postoperative…
- Trial name
- ARINE (NCT01598909)
- Testing
- Arnica
- Where
- Netherlands
- Volunteers
- 136 people
- Sponsor
- Wynand BWH Melenhorst, MD
Primary Immune Thrombocytopenia
A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids
The purpose of this study is to evaluate the effect of two different doses of ianalumab added to eltrombopag to prolong Time to Treatment Failure (TTF) in adults with primary ITP who failed previous first-line treatment with…
- Trial name
- VAYHIT2 (NCT05653219)
- Testing
- Ianalumab, Eltrombopag
- Where
- 74 sites in United States, Argentina and 22 more
- Volunteers
- 152 people
- Sponsor
- Novartis Pharmaceuticals
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative
Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
- Trial name
- NCT02272660
- Testing
- Parecoxib sodium, Normal saline injection
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
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