Clinical trials: Placebo-Post
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital
Posttraumatic Stress Disorder
Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD
The investigators will test whether intranasal oxytocin (24 IU vs placebo) will induce effects on attention bias and startle comparable to those the investigators have shown to be induced by the presence (vs absence) of a service…
- Trial name
- NCT03211013
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Palo Alto Veterans Institute for Research
Knee Pain, Knee Chondroplasty
A Randomized Double-Blind Placebo Controlled Trial to Determine the Status of Post Knee Chondroplasty Patients Administered Theramine Versus Placebo in Addition to Post Surgery Analgesics
The purpose of this study will be to show the patient response to analgesics taken post surgery when taken in combination with Theramine as opposed to Theramine-like placebo.
- Trial name
- NCT01534286
- Testing
- Theramine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Targeted Medical Pharma
Coronary Artery Bypass Surgery, Coronary Heart Disease
Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
The purpose of this study is to assess the effects of nesiritide compared to placebo when given with standard of care therapies, on kidney function, heart function and the need of other treatments in heart failure patients…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00653042
- Testing
- Nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Surgery, Oral, Pain, Postoperative
A Comparison of the Effectiveness and Safety of ULTRACET® (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAM® (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing pain after oral surgery.
- Trial name
- NCT00236483
- Testing
- tramadol hydrochloride + acetaminophen
- Volunteers
- 456 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Joint Contractures
Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures
Injured joints, especially at the elbow, are at risk for permanent motion loss, also known as joint contractures. Joint contractures limit the function of an elbow and are a recognized complication that occurs often after a…
- Trial name
- Ketotifen (NCT01902017)
- Testing
- Ketotifen
- Where
- 3 sites in Canada
- Volunteers
- 152 people
- Sponsor
- University of Calgary
Delirium
Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery
In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.
- Trial name
- NCT00699946
- Testing
- olanzapine
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Low-level Light Therapy, Cryotherapy
Comparison Between Low-level Laser Therapy, Intracanal Cryotherapy and Their Combination, on Post-endodontic Pain Level
Statement of the problem: Postoperative pain following endodontic treatment is a common complication that might require analgesics for pain relief.
- Trial name
- NCT04006717
- Testing
- Low Level Laser therapy, Intra canal Cryotherapy
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Misr International University
Post-Acute COVID-19 Syndrome
Effect of Inhaled Hydroxy Gas on Long COVID Symptoms
The goal of this clinical trial is to see if several weeks of self-administered, home-based, treatment involving breathing hydroxy gas (a mixture of hydrogen and oxygen) for at least 2 hours a day for 3 weeks, will relieve…
- Trial name
- LCHydroxy (NCT06159296)
- Testing
- Hydroxy gas
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford Brookes University
Overactive Bladder, Mild Cognitive Impairment
A Study of Fesoterodine and Oxybutynin on Cognitive Function in Mild Cognitive Impairment
The purpose of this study is to assess the effects of fesoterodine at 4mg and 8mg doses versus a placebo and oxybutynin 5mg bid versus placebo on cognitive abilities in older people with overactive bladder and mild cognitive…
- Trial name
- NCT02240459
- Testing
- fesoterodine 4mg, Oxybutynin, fesoterodine 8mg
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- University of Alberta
Dyslipidemia
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HS-10582 in Healthy Subjects and Subjects With Mildly Elevated LDL-C Levels
This study will assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of HS-10582 following single and multiple dose administration to healthy subjects and subjects with Mildly Elevated LDL-C.
- Trial name
- NCT07777003
- Testing
- HS-10582
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Cholelithiasis
Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy
This is a randomized double-blind placebo-controlled trial with a total of 100 patients who are free of gallstones at baseline. The study involves taking an oral drug (Ursodeoxycholic Acid 250mg) or a placebo twice daily for a…
- Trial name
- NCT02721862
- Testing
- Ursodeoxycholic Acid, Gallbladder Ultrasound
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people
- Sponsor
- American University of Beirut Medical Center
Pancreatitis, Diabetes
Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant
The purpose of the study is to test the effects of sitagliptin on the need for insulin (the hormone that lowers blood sugars) by patients who receive a pancreatectomy and islet autotransplant for chronic pancreatitis.
- Trial name
- NCT01186562
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Minnesota
Influenza
Study to Assess the Efficacy and Safety of GP681 Versus Placebo for Postexposure Prophylaxis Against Influenza
Index patients who are infected with influenza virus (Q-PCR positive) can be treated with anti-influenza drugs if their influenza symptoms onset was within 48 hours of screening.
- Trial name
- NCT06574503
- Testing
- GP681 40mg, GP681 Simulant
- Where
- China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.
Healthy
Placebo Controlled Study for Characterisation of Immunological Effects and Safety of Active O2
The aims of this study are: Characterisation of immunological effects of Active O2 vs. placebo after ingestion during and post standardised strenuous exercise Characterisation of safety and tolerability of Active O2 in comparison…
- Trial name
- NCT01333930
- Testing
- Active O2, Adelholzener Mineralwasser
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Adelholzener Alpenquellen GmbH
Coronary Heart Disease
A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)
This double-blind, randomized, placebo-controlled, multi-center study will evaluate the safety and efficacy of dalcetrapib in patients hospitalized for an acute coronary syndrome (ACS).
- Trial name
- NCT01323153
- Testing
- dalcetrapib
- Where
- 33 sites in United States, Czechia and 2 more
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Knee Arthroscopy, Postoperative Pain
Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy
Patients scheduled for elective knee arthroscopy under general anesthesia will be randomly assigned into three groups in a 1:1:1 ratio: placebo (saline), tramadol, and tramadol plus dexamethasone.
- Trial name
- KATD-PAIN (NCT07064993)
- Testing
- Saline, Tramadol, Tramadol + Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Arzu Esen Tekeli
Tonsillectomy
CT Evaluating the Efficacy of Pre-incisional Local Analgesia With Ropivacaine + Dexamethasone in Pain Management After Tonsillectomy
This study is a randomized, controlled, double-blind clinical trial to evaluate the effect of local infiltration of ropivacaine and dexamethasone, alone or in association, in the reduction of pain and the need for supplementary…
- Trial name
- ORL (NCT05504967)
- Testing
- Oradexon, Ropivacaine, Saline solution
- Where
- Portugal
- Volunteers
- 115 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Metabolic Processes
The Effects of Differing Cognitive Task Demands on Whole-body Energy Metabolism and Cerebral Blood-flow: Modulation by Multivitamins/Minerals and Coenzyme Q10
When completing difficult tasks, the brain requires faster delivery of energy sources (oxygen and glucose) via the blood. There is evidence to suggest that some nutritional supplements may increase blood circulation in the brain…
- Trial name
- NCT02381964
- Testing
- Supradyn® (1RDA+CoQ10), Supradyn® (3RDA)
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy Participants
A Phase I Study in Healthy Participants
A Randomized, Double-Blind, Placebo-Controlled Phase-I Clinical Study to Evaluate the Tolerability, Safety and PK Profiles of Human interferon alfa 1b inhalation solution in Healthy Adult Subjects after Administration of Single…
- Trial name
- NCT06277167
- Testing
- Human interferon alfa 1b inhalation solution
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kexing Biopharm Co., Ltd.