Clinical trials: Placebo-Post
Healthy, Men
Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
This is a Phase IIa multicenter, double-blind, placebo-controlled study in healthy men to evaluate the spermatogenesis suppression after oral administration of Dimethandrolone Undecanoate (DMAU) alone or with Levonorgestrel (LNG)…
- Conditions
- Healthy, Men, Male Contraception
- Trial name
- NCT03455075
- Testing
- Dimethandrolone-Undecanoate, Levonorgestrel 0.03 MG
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Premier Research
Healthy Male Volunteers
First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Phase I Single Ascending Dose (Part 1), phase IIa Proof Of Concept (Part 2)
- Trial name
- NCT01965301
- Testing
- BP1.5375 suspension, Diphenhydramine
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bioprojet
Photobiology
Placebo-controlled Assessment of the Effect of a Food Supplement on Skin Protection After Exposure to UV Radiation
A probiotic bacterial strain was tested in a randomized, double blind , placebo controlled clinical trial with 54 healthy male volunteers.
- Trial name
- NCT00351689
- Testing
- dietary supplement
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Radial Artery Injury, Hematoma
Ankaferd Blood Stopper for Hemostasis After Transradial Coronary Angiography
In 2008 Goker et al, introduced Ankaferd Blood Stopper (ABS) as a new hemostatic drug. Recently, ABS has been shown to produce local hemostasis by implementing topically after major arterial vessel injury.
- Conditions
- Radial Artery Injury, Hematoma, Bleed
- Trial name
- NCT02982733
- Testing
- ABS, TR Band, CS
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Acibadem University
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients
This is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of high-dose short-chain fatty acid (SCFA) supplementation on the gut microbiome and host metabolome in stable kidney…
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Renal Function, Adverse Events
- Trial name
- RENOBIOME (NCT07024238)
- Testing
- SCFA
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Advanced Breast Cancer
A Study of Everolimus Plus Exemestane in Chinese Postmenopausal Women With Estrogen Receptor Positive, Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Non-steroidal Aromatase Inhibitor
This study aimed at evaluating the safety and efficacy of everolimus plus exemestane in Chinese postmenopausal women with ER+ HER2- locally advanced, recurrent, or metastatic breast cancer after recurrence or progression on…
- Trial name
- BOLERO-5 (NCT03312738)
- Testing
- Everolimus, Exemestane
- Where
- 15 sites in China
- Volunteers
- 159 people
- Sponsor
- Novartis Pharmaceuticals
Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors
SGLT2i Effect on PTDM Development and Kidney Allograft Function in Non-diabetic Kidney Transplant Recipients: A Randomized, Doubleblind, Placebo Controlled, National Multicenter Trial
The goal of this clinical trial is to find out whether 12 months of treatment with the SGLT2 inhibitor Forxiga® (dapagliflozin 10 mg once daily), compared with placebo, can reduce the risk of developing post-transplant diabetes…
- Conditions
- Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors, Non-Diabetic Patients, Randomized Controlled Trial (RCT)
- Trial name
- SGL-TX-PTDM (NCT07682350)
- Testing
- SGLT2i
- Where
- 3 sites in Denmark
- Volunteers
- 184 people
- Sponsor
- Odense University Hospital
Meningococcal Disease, Infections, Meningococcal
Immunogenicity, Safety and 1 Year Persistence of Antibodies After Either One or Two Doses of Meningococcal ACWY Conjugate Vaccine in Healthy Children 2 Through 10 Years of Age.
This study was designed to conduct a comparative trial to further evaluate the safety, immunogenicity and antibody persistence of two doses of Novartis MenACWY conjugate vaccine, given 2 months apart, versus one dose of Novartis…
- Trial name
- NCT01682876
- Testing
- MenACWY-CRM
- Where
- 19 sites in United States
- Volunteers
- 715 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Antibiotic Side Effect, Antibiotic-associated Diarrhea
Metagenomic and Metabolomic Reconstitution of Gut Microbiota After Broad Spectrum Antibiotic Therapy
In the United States, healthcare providers prescribe over 270 million antibiotic prescriptions each year. While antibiotics have transformed medicine and methods of treating life-threatening bacterial infection, broad spectrum…
- Conditions
- Antibiotic Side Effect, Antibiotic-associated Diarrhea, Antibiotic-induced Dysbiosis, Antibiotic-induced Epithelial Barrier Disintegrity
- Trial name
- NCT04171466
- Testing
- Ciprofloxacin + Metronidazole, SH-DS01
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Seed Health
Insomnia Disorder
Cannabinol Use in Patients With Insomnia Disorder
This study aims to investigate the acute effects of cannabinol (CBN) 30 mg and 300 mg, versus placebo, on sleep architecture and next-day functioning in adults aged 25-65 years with chronic insomnia disorder.
- Trial name
- CUPID (NCT05344170)
- Testing
- 30 mg Cannabinol (CBN), 300 mg Cannabinol (CBN)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Woolcock Institute of Medical Research
Post-Treatment Lyme Disease Syndrome
Ceftriaxone for Post-Treatment Lyme Disease
Lyme disease is a public health crisis in the US. It is estimated that over 400,000 cases occur every year with 10-20% of those infected going on to develop Post-Treatment Lyme disease Syndrome (PTLDS).
- Trial name
- NCT06785402
- Testing
- Ceftriaxone treatment
- Where
- United States
- Sponsor
- Hackensack Meridian Health
Type 1 Diabetes, Diabetic Ketoacidosis
Study to Explore the Effect of Dapagliflozin and Stress in Adolescent and Adult Subjects With Type 1 Diabetes (T1D)
Type 1 Diabetes is characterized by an absolute lack of insulin caused by autoimmune ß-cell destruction. Looking for different therapeutic approaches, beyond the administration of Insulin SGLT-Inhibitors (SGLT=sodium-glucose…
- Trial name
- Dapa-Stress (NCT04234867)
- Testing
- Dapagliflozin, Stress
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Post-infective Bowel Dysfunction, Functional Gastrointestinal Disorders
Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates
The purpose of the study is explore the issues that relate to testing a particular dietary treatment, the low FODMAP diet, in a randomised trial using an appropriate control diet with which to compare it.
- Trial name
- CEDRIC (NCT02232373)
- Testing
- low FODMAP dietary advice, Maltodextrin, Oligofructose
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Nottingham
Aneurysmal Subarachnoid Hemorrhage
Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)
The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared…
- Trial name
- NCT04148105
- Testing
- Cilostazol 100 MG
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Henry Ford Health System
Surgical Adhesions
Study of PXL01 Versus Placebo to Inhibit Adhesion Formation After Flexor Tendon Surgery
The objectives of the study are to assess efficacy, safety, and handling of PXL01 in patients with flexor tendon injury in zone I or II.
- Trial name
- PHSU02 (NCT01022242)
- Testing
- PXL01
- Where
- 15 sites in Denmark, Germany and 1 more
- Volunteers
- 138 people
- Sponsor
- Pergamum AB
Autism Spectrum Disorder
Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Adults With Autism Spectrum Disorder
Oxytocin (OT) is a small, naturally occurring peptide currently in clinical use to stimulate lactation in breastfeeding women. The intranasal administration of OT has recently attracted attention as a potential novel treatment in…
- Trial name
- NCT02414503
- Testing
- 8IU intranasal oxytocin, 24IU intranasal oxytocin, OptiNose Breath Powered Bi
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- OptiNose AS
Healthy Volunteers
Assess Safety, Tolerability and Pharmacokinetic (PK) of AZD1704 in Healthy Japanese Male and Non-Fertile Female Volunteers
The primary objective of this study is to investigate the safety and tolerability of AZD1704 following single ascending doses in healthy Japanese male and non-fertile female volunteers by assessment of adverse events (AEs), vital…
- Trial name
- NCT00736788
- Testing
- AZD1704
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SIM0278 in Chinese Healthy Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled trial of SIM0278 in healthy subjects. The study will be conducted in 2 parts. Part 1 is single ascending dose study. Part 2 is multiple ascending dose study.
- Trial name
- NCT06022354
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Postpartum Women
The Effects of Acupressure on Pain After Cesarean Section
Purpose: To examine the effect of Pericardium 6 and Large Intestine 4 acupressure on pain and analgesia consumption in women after cesarean section.
- Trial name
- NCT04337801
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
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