Clinical trials: Placebo-Post
Autoimmune Diseases
A Study of the Safety, Tolerability, Pharmacokinetics and Food Effect After Single and Multiple Ascending Oral Doses
This is a Phase I Healthy volunteer study with the primary objective to evaluate the safety and pharmacokinetics profile of AX-158. The first part will evaluate single ascending dose administrations.
- Trial name
- NCT05218434
- Testing
- AX-158
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Artax Biopharma Inc
Healthy
Safety, Tolerability, and Pharmacokinetic Evaluations of CKR-051 After Transdermal Administration in Healthy Male Subjects
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of CKR-051 in healthy participants. This study aiming to develop an agent for skin regeneration; potential treatments include acute and chronic wounds…
- Trial name
- NCT05833906
- Testing
- CKR-051 Dose 1, CKR-051 Dose 2, CKR-051 Dose 3
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- CK Regeon Inc.
Posttraumatic Stress Disorder
Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel
The goal of this clinical trial is to learn if MDMA-assisted therapy can treat PTSD in participants with PTSD. Researchers will compare two sessions of MDMA-assisted therapy with two sessions of low dose (active placebo)…
- Trial name
- NCT00402298
- Testing
- Full Dose Midomafetamine HCl, Low Dose Midomafetamine HCl
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Resilient Pharmaceuticals
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Healthy
Interaction Study of Clopidogrel 600/150 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects
Primary objective: Assess the effects of clopidogrel (600 mg loading dose followed by 4 days 150 mg/day) on Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with omeprazole 80 mg/day compared to…
- Trial name
- NCT01129414
- Testing
- Clopidogrel, Omeprazole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sanofi
Breast Cancer
Placebo-controlled Evaluation of Cocculine® Efficacy in the Management of Nausea After Chemotherapy in Breast Cancer.
The purpose of the study is to determine whether a homeopathic remedy (Cocculine®) is effective in the prevention of chemotherapy-induced nausea in non metastatic breast cancer.
- Trial name
- NCT00409071
- Testing
- Cocculine®
- Where
- France
- Volunteers
- 431 people
- Sponsor
- Centre Leon Berard
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy
VVZ-149 is a novel analgesic drug candidate that shows a potential analgesic activity inhibiting GlyT2 and 5HT2A simultaneously.
- Trial name
- NCT02522598
- Testing
- VVZ-149 injections
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Vivozon, Inc.
Poststroke/CVA Paresis
Efficacy of Hand Exoskeleton Controlled by BCI in Post Stroke Patients
The purpose of this study is to assess the efficacy of non-invasive BCI-exoskeleton technology based on EEG patterns recognition matching to motor imagery in post-stroke patients with hand paresis.
- Trial name
- iMove (NCT02325947)
- Testing
- hand exoskeleton, brain-computer interface (BCI),
- Where
- Russia
- Volunteers
- 75 people
- Sponsor
- Russian Academy of Medical Sciences
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Post Traumatic Stress Disorder
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
This study will enroll patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD).
- Trial name
- NCT05391971
- Testing
- Bupivacaine, Saline
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- NYU Langone Health
Xerophthalmia
Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
The objective is to evaluate the safety, local tolerability, and pharmacokinetics of NCP112 eye drops through single and multiple dose-escalation ocular administrations in healthy adults.
- Trial name
- NCT06263998
- Testing
- NCP112
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Cholangiocarcinoma
Regorafenib Versus Placebo to Treat Cholangiocarcinoma
The study is a multicenter randomized (1:1) placebo-controlled, double-blinded phase II trial aiming to demonstrate an improvement of median PFS when treating locally advanced unresectable or metastatic patients suffering from an…
- Trial name
- REACHIN (NCT02162914)
- Testing
- Regorafenib/active
- Where
- 12 sites in Belgium
- Volunteers
- 66 people
- Sponsor
- Erasme University Hospital
Human Immunodeficiency Virus
Single Ascending Dose (SAD)/Multiple Ascending Dose(MAD) Safety/Pharmacokinetic (PK) Study of KM-023
The purpose of this study is to investigate the safety and pharmacokinetics of KM-023 after single/multiple dosing.
- Trial name
- NCT01348516
- Testing
- KM-023
- Where
- South Korea
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Kainos Medicine Inc.
PTSD
Quetiapine Treatment for Post-Traumatic Stress Disorder (PTSD)
The purpose of the study is to determine if quetiapine is effective in the treatment of PTSD.
- Trial name
- PTSD (NCT00237393)
- Testing
- Quetiapine
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Ralph H. Johnson VA Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Changes in Cardiac Function in COPD Patients After Administration of Budesonide/Formoterol (Symbicort®) Versus Placebo
To investigate whether Budesonide/Formoterol (Symbicort ®) therapy can improve heart function at rest by decreasing lung hyperinflation in patients with COPD (Chronic Obstructive Pulmonary Disease).
- Trial name
- AZCO (NCT01760304)
- Testing
- Budesonide / Formoterol
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brigham and Women's Hospital
Healthy Volunteers
Double-blind, Randomized, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Doses of XC243 After Single and Multiple Oral Administration in Healthy Volunteers.
A double-blind, randomized, placebo-controlled, Phase I clinical study of the safety, tolerability and pharmacokinetics (PK) of ascending doses of XC243 after single and multiple oral administration in healthy volunteers.
- Trial name
- NCT05628116
- Testing
- XC243 50 mg single, XC243 100 mg single, XC243 200 mg single-dose food effect
- Where
- Russia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- PHARMENTERPRISES LLC
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Post-Tonsillectomy
Traumeel for Post-Tonsillectomy Pain
Tonsillectomy is one the most common procedures in ear, nose and throat (ENT) medicine. Following surgery patients suffer from severe pain and difficulty on swallowing, while analgesic treatment has limited efficacy and potential…
- Trial name
- NCT00410332
- Testing
- Traumeel S
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Long COVID, Sars-CoV-2 Infection
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of…
- Conditions
- Long COVID, Sars-CoV-2 Infection, Coronavirus Infections, COVID-19
- Trial name
- REVERSE-LC (NCT06631287)
- Testing
- Baricitinib
- Where
- 17 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wes Ely
IDA in the Post-bariatric Surgical Patient
Intravenous (IV) Versus Oral Iron Treatment of Iron Deficiency Anemia in the Post-operative Bariatric Surgical Patient
The aim of the study is to compare two accepted treatments for iron deficiency anemia (oral ferrous sulfate and intravenous ferumoxytol) for efficacy and speed of response in the treatment of iron deficiency anemia (IDA) in the…
- Trial name
- NCT03777514
- Testing
- Ferumoxytol, Ferrous sulfate, Oral vitamin C
- Sponsor
- Johns Hopkins University
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