Clinical trials: Placebo-Pre
Pain, Anxiety
Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture
The purpose of this study is to evaluate the amount of anxiety and pain felt by children during procedures that require a needle stick after using a topical anesthetic or placebo cream.
- Trial name
- NCT00676364
- Testing
- 4% lidocaine topical anesthetic cream
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Jenny Boucher, PharmD
Arthritis, Rheumatoid, Healthy
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effects of Multiple Rising Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate Therapy
To evaluate the safety and tolerability of multiple doses of BI 655064 administered subcutaneously in healthy volunteers (HVs) and in rheumatoid arthritis (RA) patients.
- Trial name
- NCT01751776
- Testing
- BI 655064
- Where
- 25 sites in Czechia, Germany and 4 more
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Constipation
Pre-biotics and Probiotics for Constipation in Parkinson's Disease
Constipation is the most frequent (prevalence, about 60%) dysautonomic non motor symptom affecting Parkinson's disease (PD) patients.
- Trial name
- NCT02459717
- Testing
- Probiotics and prebiotic
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Emanuele Cereda
Pre-Eclampsia
Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia?
The purpose of the study is to test the hypothesis that a short course of atorvastatin can improve vascular function in women with a history of preeclampsia, compared to placebo.
- Trial name
- PVS3 (NCT01278459)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Oxford
Healthy
A Study to Evaluate the Safety and Immunogenicity of Seasonal Influenza Vaccine and an Adenovirus Serotype 26- Based Vaccine Encoding for the Respiratory Syncytial Virus Pre-fusion F Protein (Ad26.RSV.preF), With and Without Co-administration, in Adults Aged 60 Years and Older in Stable Health
The purpose of this study is to demonstrate the non-inferiority of the concomitant administration of an adenovirus serotype 26- based vaccine encoding for the respiratory syncytial virus pre-fusion F protein (Ad26.RSV.preF) and…
- Trial name
- NCT03339713
- Testing
- Ad26.RSV.preF, Fluarix
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Psoriasis
Study of Secukinumab With 2 mL Pre-filled Syringes
The aim of the study was to demonstrate efficacy, safety and tolerability of 2 mL pre-filled syringe of 300 mg secukinumab in treatment of moderate to severe plaque psoriasis.
- Trial name
- ALLURE (NCT02748863)
- Testing
- Secukinumab 2 mL form, Secukinumab 1 mL form
- Where
- 52 sites in United States, Belgium and 9 more
- Volunteers
- 214 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
The Effect of Grape Seed Extract on Blood Pressure in People With Pre-Hypertension
In this research study, the investigators are interested in learning how extracts from grape seeds can help those individuals with high blood pressure.
- Trial name
- GSE (NCT00979732)
- Testing
- grape seed extract
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Primary Hyperparathyroidism
Bisphosphonate Prior to Parathyroidectomy in Primary Hyperparathyroidism
This study is a randomized, double-blinded, placebo-controlled trial investigating the effects of zoledronic acid (ZOL) versus placebo in patients with primary hyperparathyroidism (PHPT) undergoing parathyroidectomy (PTX).
- Trial name
- ZOLPHPT (NCT06859580)
- Testing
- Zoledronic acid 4 mg, Natriumklorid 9 mg/ml, Fresenius Kabi
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Postmenopause, Premenopause
Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks.
- Trial name
- NCT00901589
- Testing
- marine n-3 polyunsaturated fatty acids, thistle oil
- Where
- Denmark
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Obstetric Labour, Premature
The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor
Pre-Term Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00404768
- Testing
- GSK221149A
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 93 people
- Sponsor
- GlaxoSmithKline
Anemia
A Study to Evaluate the Effectiveness and Safety of Epoetin Alfa During the Period When One is Donating One's Own Blood Before Surgery.
The purpose of this study is to evaluate the whether epoetin alfa stimulates the bone marrow to produce red blood cells and therefore increases a patient's ability to self-donate blood prior to major surgery.
- Trial name
- NCT00270179
- Testing
- epoetin alfa
- Volunteers
- 17 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
PreDiabetes
To Evaluate the Impact of Consumption of a Bioactive Compound on Fasting Blood Glucose Levels in Asian Indians With Pre-diabetes
This is randomized placebo controlled, double-blinded, parallel arm study on free living Asian Indians. Eligible subjects will undergo one-week run-in period and subjects will be asked to maintain their usual diet and exercise…
- Trial name
- NCT06417840
- Testing
- N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT)
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Brightseed
Diabetes Mellitus, Type 2, Renal Insufficiency
Efficacy and Safety of Empagliflozin (BI 10773) in Patients With Type 2 Diabetes and Renal Impairment
This study will investigate the efficacy and safety of the BI 10773 in type 2 diabetic patients with renal impairment in order to provide these data for approval for BI 10773 as an antidiabetic agent by regulatory authorities.
- Trial name
- NCT01164501
- Testing
- BI 10773
- Where
- 127 sites in United States, Canada and 13 more
- Volunteers
- 741 people
- Sponsor
- Boehringer Ingelheim
Pre-exposure Prophylaxis Against Pneumonic Plague in Healthy Adults
Ph1, Randomized, Double-Blind and Controlled, Dose Escalation and Expansion Study to Assess the Safety and Pharmacokinetics of JST-010 in Healthy Adults
The goal of this clinical trial is to learn if a single dose of the study drug, JST-010, is safe and tolerable when administered by injection into the arm or thigh muscle of healthy men and women aged 18 to 55.
- Trial name
- NCT06943378
- Testing
- Monoclonal antibody JST-010
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Just-Evotec Biologics
HIV-1 Infections, HIV Infections
Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples
Randomized, blinded, placebo-controlled trial to demonstrate if pre-exposure prophylaxis decreases HIV-1 acquisition among HIV-1 uninfected individuals within HIV-1 discordant couples.
- Trial name
- Partners PrEP (NCT00557245)
- Testing
- Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)
- Where
- 9 sites in Kenya, Uganda
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tonsillectomy
CT Evaluating the Efficacy of Pre-incisional Local Analgesia With Ropivacaine + Dexamethasone in Pain Management After Tonsillectomy
This study is a randomized, controlled, double-blind clinical trial to evaluate the effect of local infiltration of ropivacaine and dexamethasone, alone or in association, in the reduction of pain and the need for supplementary…
- Trial name
- ORL (NCT05504967)
- Testing
- Oradexon, Ropivacaine, Saline solution
- Where
- Portugal
- Volunteers
- 115 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Vascular Access Ports
Randomized Assessment of Antibiotic Prophylaxis Prior to Port Placement
A randomized, double blind, placebo-controlled clinical trial assessing the utility of antibiotic prophylaxis prior to Totally Implanted Venous Access Device (TIVAD) insertion.
- Trial name
- NCT05304871
- Testing
- Cefazolin, saline
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pre-Exposure Prophylaxis, Coronavirus
Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus?
On 11 March 2020, the World Health Organization declared SARS-CoV-2 (commonly called COVID-19) a global pandemic. As in any pandemic, maintaining the health and safety of the healthcare workforce is of great importance as health…
- Conditions
- Pre-Exposure Prophylaxis, Coronavirus, SARS-CoV 2
- Trial name
- HEROs (NCT04374942)
- Testing
- Hydroxychloroquine
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Megan Landes
Post Traumatic Stress Disorder
Effect of Exercise on Post-traumatic Growth Among Health Care Providers With Post-traumatic Stress
The purpose of designing this randomized control trial is to observe the effect of nature-based walk on post-traumatic growth and Psychophysiological alterations associated with it, in traumatic stress among health care providers…
- Trial name
- NCT04592770
- Testing
- Nature based walk therapy, Sit in nature
- Where
- Pakistan
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Patients Referred for an Isolated or a Combined Surgical Correction of Functional Moderate to Severe Tricuspid
Levosimendan Versus Placebo Before Tricuspid Valve Surgery in Patients With Right Ventricular Dysfunction
A Prospective, multicenter, randomized (two arms, parallel groups); double-blind, placebo-controlled in order to assess the ability of preoperative levosimendan to prevent post-operative low cardiac output in high-risk patients…
- Trial name
- LEONARD (NCT05233202)
- Testing
- Levosimendan
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris