Clinical trials: Placebo-Pre
Pain
Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
The purpose of this study is to see if using misoprostol makes the intrauterine device insertion easier and less painful in women who have never had a baby.
- Trial name
- NCT01307111
- Testing
- Misoprostol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Upper Respiratory Tract Infections
Nasal Spray With Glucose Oxidase Preventing Common Cold in Pre-school Children
To investigate if use of glucosoxidas nasal spray can reduce the number of days with upper respiratory tract infections in children beyond 4 years.
- Trial name
- NCT01883427
- Testing
- Glucose oxidase
- Where
- 4 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Krister Tano
Multi-drug Resistant Tuberculosis
A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis
The purpose of this study is to provide safety and efficacy data for TMC207 and to demonstrate that TMC207 added to a background regimen (BR) is superior to treatment with the BR plus placebo.
- Trial name
- NCT01600963
- Testing
- Arm A Double-blind Phase: TMC207, Treatment Failure During Double-blind Phase: TMC207, Treatment Failure During Follow-up Phase: TMC207
- Where
- 44 sites in Brazil, Cambodia and 15 more
- Sponsor
- Janssen Infectious Diseases BVBA
Major Depressive Disorder
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
The main research hypothesis for this study is that, among patients with Major Depressive Disorder (MDD) who have responded inadequately to treatment with SSRIs or SNRIs, the degree of improvement, as measured by the change from…
- Trial name
- NCT01318434
- Testing
- EB-1010 25mg BID, SSRI Active, EB-1010 50mg BID
- Where
- 43 sites in United States
- Volunteers
- 342 people
- Sponsor
- Euthymics BioScience, Inc.
Pain, Postoperative
Pre-Emptive Analgesia in Dental Implant Surgery
To determine the clinical effectiveness of combined use of pre-emptive analgesia and long acting anesthesia for pain suppression following dental implant surgery as measured by a validated numerical rating scale and the…
- Trial name
- NCT03243032
- Testing
- Ibuprofen 600 mg, Local anesthetic Group 1, Local anesthetic Control
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Satheesh Elangovan
Healthy Subjects
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects
The purpose of this study is to evaluate the safety and tolerability of single and multiple oral doses of ESN364 in healthy Japanese male and pre- and post-menopausal female subjects.
- Trial name
- NCT03436849
- Testing
- ESN364
- Where
- Japan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
RSV Infection
Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults
CLO-SCB-1019-002 is the first study of SCB-1019T vaccine for revaccination in older adults who were previously vaccinated with AREXVY. The safety, tolerability and immunogenicity of SCB-1019T are assessed.
- Trial name
- NCT06843317
- Testing
- Candidate vaccine, SCB-1019T, AREXVY
- Where
- 5 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clover Biopharmaceuticals USA, LLC
Moderate to Severe Plaque-type Psoriasis
First Study of Secukinumab in Pre-filled Syringes in Subjects With Chronic Plaque-type Psoriasis: Response at 12 Weeks
The purpose of this study is to demonstrate efficacy of secukinumab at Week 12 based on PASI and IGA response rates versus placebo in subjects with moderate to severe chronic plaque-type psoriasis.
- Trial name
- FEATURE (NCT01555125)
- Testing
- secukinumab 150 mg, secukinumab 300 mg
- Where
- 33 sites in United States, Canada and 3 more
- Volunteers
- 177 people
- Sponsor
- Novartis Pharmaceuticals
Pain, Post Procedural, Pain, Procedural
Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy
The purpose of this study is to compare the effectiveness of Tramadol and diclofenac in reducing pain during outpatient hysteroscopy.
- Trial name
- NCT02419651
- Testing
- Tramadol, Diclofenac
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Cairo University
Ocular Infection
A Phase 2, Open-Label, Randomized, Parallel Group, Placebo-Controlled, Single-Center Study to Assess Anti-microbial Efficacy and Safety of DCN01 Compared to Unisol® Following Topical Periocular Administration in Healthy Volunteers
This proof-of-concept study evaluates the clinical efficacy and safety of DCN01 in prepping of the periocular region.
- Trial name
- NCT01853722
- Testing
- DCN01, Unisol
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Deacon Biosciences, Inc.
Atrial Fibrillation With Rapid Ventricular Response, Hypotension Drug-Induced
Diltiazem in the Treatment of Atrial Fibrillation or Atrial Flutter With Rapid Ventricular Rate
The purpose of this study is to see how well calcium pre-treatment works for decreasing incidence of drug-induced hypotension after diltiazem administration for treatment of atrial flutter with rapid ventricular rate.
- Trial name
- AFFRVR (NCT05661942)
- Testing
- Calcium pre-treatment
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Wake Forest University Health Sciences
HIV Infections
FEM-PrEP (Truvada®): Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women
This Phase III, double-blind, randomized, placebo-controlled trial enrolled HIV-negative women from 4 sites in 3 countries (Kenya, Tanzania, South Africa).
- Trial name
- NCT00625404
- Testing
- Truvada
- Where
- 4 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- FHI 360
Induced Vaginal Delivery
IV PAPAVERINE Prior to Propess for Labor Induction
The investigators aim to evaluate the effect of administering papaverine prior to PGE2 insertion on changes in Bishop-scores and on the induction-to-delivery interval. Researchers will compare drug papaverine to a placebo
- Trial name
- NCT06550232
- Testing
- Papaverine
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI)
Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients
The goal of this clinical trial is to learn if giving the drug empagliflozin before versus after a heart procedure called primary PCI (percutaneous coronary intervention) affects how much heart muscle is damaged during a heart…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI), Coronary Artery Disease
- Trial name
- TEMPO-STEMI (NCT07749014)
- Testing
- empagliflozin
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- Rehman Medical Institute - RMI
Ovarian Cancer, Cervical Cancer
Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates.
The prevalence of anemia in gynecologic oncology new patients has been seen in previous studies to be as high as 35-59%. this population includes women with several types of gynecologic malignancies.
- Conditions
- Ovarian Cancer, Cervical Cancer, Uterine Cancer, Anemia
- Trial name
- NCT01953107
- Testing
- Oral Ferrous Fumarate
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anesthesia
Magnesium for Shivering in Epidural Lidocaine Deliveries
Magnesium has been shown to decrease the shivering experienced from neuraxial anesthesia. This study aims to investigate whether magnesium decreases the shivering experienced in parturients undergoing labor epidural anesthesia…
- Trial name
- Mag-SHIELD (NCT03439358)
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Polycystic Ovary Syndrome, in Vitro Fertilization
Vitamin D and Pregnancy Outcome in PCOS Patients
This multicenter double-blinded placebo-controlled randomised trial aims to evaluate the effectiveness of vitamin D supplementation prior to IVF on the live birth rate in women with PCOS.
- Trial name
- NCT04082650
- Testing
- vitamin D
- Where
- 2 sites in China
- Volunteers
- 876 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Human Metapneumovirus and Human Parainfluenza Infection
Safety and Immunogenicity of mRNA-1653, a Combined Human Metapneumovirus (hMPV) and Parainfluenza Virus Type 3 (PIV3) Vaccine, in Healthy Adults, and Children 12 to 59 Months of Age With Serologic Evidence of Prior Exposure
This clinical study will assess the safety and immunogenicity of 2 dose levels of mRNA-1653, a combined human metapneumovirus and human parainfluenza virus type 3 vaccine, in healthy adults (18 to 49 years of age) and 2 dose…
- Trial name
- NCT04144348
- Testing
- mRNA-1653
- Where
- 19 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Metastatic Pancreatic Ductal Adenocarcinoma
Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma
There will be two phases to this study. The lead-in phase will evaluate the safety, pharmacokinetics, and define the maximum tolerated dose (MTD) of momelotinib (MMB) combined with nab-paclitaxel and gemcitabine (nab-P + G) in…
- Trial name
- NCT02101021
- Testing
- Momelotinib, Nab-paclitaxel, Gemcitabine
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Social Anxiety Disorder
fMRI Study Comparing BOLD Activation Patterns Using GW679769 In Subjects With Social Anxiety Disorder
Evidence suggests the use of neuroimaging to detect therapeutic effects of anxiolytic treatment when appropriate cognitive-emotional tasks are use to activate the emotional brain neurocircuitry believed to be involved in the core…
- Trial name
- NCT00332046
- Testing
- GW679769
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- GlaxoSmithKline