Clinical trials: Placebo-Pre
Crohn's Disease
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.
- Trial name
- NCT03104413
- Testing
- risankizumab SC, risankizumab IV
- Where
- 403 sites in United States, Argentina and 41 more
- Volunteers
- 618 people
- Sponsor
- AbbVie
Breast Cancer
JYP0035 Capsules Plus Fulvestrant in PIK3CA-Mutant HR+/HER2- Advanced Breast Cancer
This is a Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of JYP0035 Capsules in Combination With Fulvestrant in Patients With PIK3CA-Mutated, Hormone…
- Trial name
- NCT07784036
- Testing
- JYP0035 plus Fulvestrant
- Volunteers
- 171 people
- Sponsor
- Chengdu JOYO pharma Co., Ltd.
Respiratory Syncytial Virus (RSV)
Safety and Immunogenicity of the RSV-F Vaccine in Older Adults Previously Treated With the Same Vaccine or Placebo in the Prior Year.
This study will enroll subjects who received the RSV F vaccine or placebo in the earlier study (RSV-E-201, Year 1) and re-randomize them to receive either vaccine or placebo in a second season.
- Trial name
- NCT02593071
- Testing
- RSV-F Vaccine
- Where
- 10 sites in United States
- Volunteers
- 1,330 people, healthy volunteers welcome
- Sponsor
- Novavax
Urge Incontinence, Overactive Bladder
The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder
The purpose of this study is to investigate the effect of Lidocaine solution versus placebo (isotonic Sodium Chloride NaCl) disposed inside the urinary bladder as intravesical anesthesia prior to onabotulinum toxin A injections…
- Conditions
- Urge Incontinence, Overactive Bladder, Anesthesia, Local, Pain, Procedural
- Trial name
- NCT05415865
- Testing
- Alkalinized Lidocaine
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Herlev and Gentofte Hospital
Advanced Hepatocellular Carcinoma
A Trial of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With FOLFOX4 in Subjects With Advanced HCC Who Have Never Received Prior Systemic Treatment.
The study is being conducted to evaluate the efficacy and safety of SHR-1210 plus FOLFOX4 in subjects with advanced HCC who have never received prior systemic treatment compared to placebo plus FOLFOX4.
- Trial name
- NCT03605706
- Testing
- SHR-1210, FOLFOX4
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Primary Myelofibrosis, Myeloproliferative Neoplasm
P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk
This is a phase 3 double-blind clinical trial arm to test Ropeginterferon alfa-2b (P1101) in adult patients with Primary Myelofibrosis (PMF) at early stage or low to medium risk.
- Trial name
- NCT06468033
- Testing
- Ropeginterferon alfa-2b
- Where
- 73 sites in United States, Canada and 7 more
- Volunteers
- 160 people
- Sponsor
- PharmaEssentia
Cutaneous Leishmaniasis
Safety, False-Positive Reactions and Sensitizing Properties of Leishmania Tropica Skin Test Antigen
The efficacy of LtSTA as a skin test antigen depends upon the sensitivity and specificity of the product. This study has been designed to measure the skin test responses to 15, 30, or 50µg doses of LtSTA.
- Trial name
- NCT00633009
- Testing
- Leishmania tropica Skin Test Antigen (LtSTA)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nielsen BioSciences, Inc.
Type 2 Diabetes Mellitus
Safety, Tolerability, and Activity of ISIS 113715 in People With Type 2 Diabetes Mellitus Who Have Not Received Prior Treatment
The aim of this study is to evaluate the safety, tolerability, and pharmacokinetics of five ISIS 113715 intravenous dose cohorts in drug-naïve type 2 diabetics.
- Trial name
- NCT00330330
- Testing
- ISIS 113715
- Where
- 10 sites in Poland, Russia
- Volunteers
- 96 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Hysterectomy, Blood Loss, Surgical
IV Tranexamic Acid Prior to Hysterectomy
The objective of this study is to determine the effect of 1g of IV tranexamic acid given within 1 hour pre-operatively on intraoperative blood loss at time of hysterectomy.
- Trial name
- NCT02911831
- Testing
- Tranexamic Acid, Sodium Chloride
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Northwestern University
NSCLC
Iressa vs Best Supportive Care - 2nd/3rd Line Survival Study
This study is being carried out to see if adding ZD1839 to other standard supportive care is more effective than standard supportive care alone for the treatment of patients with NSCLC whose disease has recurred after previous…
- Trial name
- NCT00242801
- Testing
- Gefitinib
- Where
- 211 sites in Argentina, Australia and 30 more
- Volunteers
- 1,692 people
- Sponsor
- AstraZeneca
Cancer
Procrit Versus Placebo to Determine Efficacy in Pre-Operative Major Surgical Oncology Operations
The purpose of this study is to evaluate the effectiveness of a two-dose regimen of Procrit prior to a major surgical oncology operation.
- Trial name
- NCT00624312
- Testing
- Procrit
- Where
- United States
- Sponsor
- University of Louisville
HIV Infections
A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients
The purpose of this study is to compare 4 different combinations of anti-HIV drugs and to determine the number of people whose HIV blood levels decrease to 200 copies/ml or less while on the treatment.
- Trial name
- NCT00000912
- Testing
- Indinavir sulfate, Abacavir sulfate, Amprenavir
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 475 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Elective Laproscopic Bilateral Inguinal Hernia, Elective Laproscopic Cholecystectomy
Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy
A Prospective Double Blind RCT: Controlled Release Oxycodone 10 mg On a 12 h Dosing Schedule Started With The Premedication ,Placebo Controlled Study,On Post Operative Analgesia Management in Laparoscopic Cholecystectomy and…
- Trial name
- NCT00480142
- Testing
- Oxycodone 10 mg
- Volunteers
- 100 people
- Sponsor
- Kaplan Medical Center
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hypogonadism, Pre-frail Seniors
Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors
The overall purpose of this study is to test the individual and combined effect of transdermal testosterone and/or Vitamin D in reducing fall risk and improve function in pre-frail hypogonadal senior men.
- Trial name
- T&D (NCT02419105)
- Testing
- Testosterone, Colecalciferol
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University of Zurich
ST-elevation Myocardial Infarction (STEMI)
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI
This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the ambulance if they meet all eligibility criteria.
- Trial name
- CELEBRATE (NCT04825743)
- Testing
- zalunfiban
- Where
- 45 sites in United States, Canada and 6 more
- Volunteers
- 2,463 people
- Sponsor
- CeleCor Therapeutics
Knee Arthropathy, Hip Arthritis
Concepts for Analgosedation During Placement of Regional Anaesthesia Before Operations.
Aim of the study is to specify the best analgosedation technique during placement of regional anaesthesia from the patients' view.
- Conditions
- Knee Arthropathy, Hip Arthritis, Fractures, Closed
- Trial name
- NCT04026074
- Testing
- Fentanyl, Remifentanil, Clonidine
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Postoperative Pain
Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy
The purpose of this study is to prospectively determine the influence of immediate pre-operative gabapentin administration on acute postoperative pain.
- Trial name
- Gabapentin (NCT02359110)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Migraine Prophylaxis
An Efficacy and Safety Study of Fremanezumab in Adults With Migraine
The purpose of this study is to evaluate the efficacy, safety, and tolerability of monthly and quarterly subcutaneous (sc) injections of fremanezumab compared with sc injections of placebo in participants with chronic migraine…
- Trial name
- FOCUS (NCT03308968)
- Testing
- Fremanezumab
- Where
- 113 sites in United States, Belgium and 12 more
- Volunteers
- 838 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Hepatocellular Carcinoma
Ph 3 ADI-PEG 20 Versus Placebo in Subjects With Advanced Hepatocellular Carcinoma Who Have Failed Prior Systemic Therapy
This is a study of ADI-PEG 20 (pegylated arginine deiminase), an arginine degrading enzyme versus placebo in patients with hepatocellular carcinoma who have failed prior systemic treatment (chemotherapy).
- Trial name
- ADI-PEG 20 (NCT01287585)
- Testing
- ADI-PEG 20 (arginine deiminase formulated with polyethylene glycol), Best Supportive Care
- Where
- 73 sites in United States, China and 4 more
- Volunteers
- 636 people
- Sponsor
- Polaris Group