Clinical trials: Placebo-Pre
Endometriosis
A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain
The purpose of this global Phase 2 study is to determine the efficacy, safety, and tolerability of 3 dose levels of OG-6219 in pre-menopausal women between 18 and 49 years of age (inclusive), who have moderate to severe…
- Trial name
- ELENA (NCT05560646)
- Testing
- OG-6219
- Where
- 86 sites in United States, Belgium and 9 more
- Volunteers
- 354 people
- Sponsor
- Organon and Co
Hypoactive Sexual Desire Disorder
Lybridos in Pre-and Postmenopausal Women With Hypoactive Sexual Desire Disorder
A double-blind, randomized, placebo-controlled, dose-finding study to investigate the safety and efficacy of Lybridos in the domestic setting in healthy female subjects with hypoactive sexual desire disorder and maladaptive…
- Trial name
- NCT02101203
- Testing
- 0.5 mgTestosterone + 10 mg Buspirone
- Where
- 10 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emotional Brain NY Inc.
Renal Dialysis
Mannitol Use During Cadaveric Kidney Transplantation
We propose a placebo controlled randomized study on the use of mannitol as an agent to protect against delayed graft function, during the surgical procedure of kidney transplantation from a cadaver.
- Trial name
- NCT04705402
- Testing
- Mannitol, Saline
- Volunteers
- 32 people
- Sponsor
- Rabin Medical Center
Atrial Fibrillation With Rapid Ventricular Response, Hypotension
Pre-diltiazem, Calcium Versus Placebo for Atrial Fibrillation With Rapid Ventricular Response
The goal of this randomized double blind controlled trial is to learn about the effects of calcium when it is given prior to diltiazem for patients with atrial fibrillation ( a type of irregular heart beat) who have rapid…
- Trial name
- NCT05691959
- Testing
- Calcium
- Volunteers
- 378 people
- Sponsor
- Ascension Health
Intervention
To Evaluate the Impact of Consumption of Bioactive Compounds Extracted From Hemp Hull and Black Pepper on Fasting Blood Glucose Levels in People With Pre-diabetes: A Randomized Placebo-Controlled Parallel Arm Trial
This is randomized controlled parallel arm study on free living Asian Indians. Eligible subjects will undergo one-week run-in period and subjects will be asked to maintain their usual diet and exercise regime.
- Trial name
- NCT06454773
- Testing
- NCT/NFT
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Anemia, Renal Insufficiency, Chronic
15141 Fixed Dose Correction / naïve and Pre Dialysis (Europe and Asia Pacific)
Anaemia is a condition in which blood has a lower than normal number of red blood cells. It can also occur if red blood cells do not contain enough haemoglobin, an oxygen carrying part of blood.
- Trial name
- DIALOGUE 1 (NCT02021370)
- Testing
- BAY85-3934
- Where
- 56 sites in Australia, Bulgaria and 12 more
- Volunteers
- 121 people
- Sponsor
- Bayer
Pre-diabetes
7-Ketolithocholic Acid in Prediabetes
7-Ketolithocholic Acid, a naturally occurring bile acid, is a novel food currently under investigation for potential metabolic benefits, including glucose-lowering effects.
- Trial name
- NCT07650123
- Testing
- 7-KLCA, Diet and Physical Activity
- Where
- 8 sites in Italy
- Volunteers
- 100 people
- Sponsor
- ICE S.p.A.
Placebo-Pre, Placebo-Post
TetraSOD® Supplementation and Exercise Performance
Tetraselmis chuii (TetraSOD) is a marine microalgae that has been reported to improve antioxidant responses in human skeletal muscle cells treated with TetraSOD and to improve recovery from muscle damaging exercise in humans…
- Conditions
- Placebo-Pre, Placebo-Post, Tetraselmis Chuii-Pre, Tetraselmis Chuii-Post
- Trial name
- NCT06831656
- Testing
- Tetraselmis chuii-Pre, Tetraselmis chuii-Post
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Bowel Preparation for Colonoscopy
Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy
The primary outcomes of this procedure will be: 1. The cleanliness of the prep as measured by the Ottawa Scale (attachment a). Secondary outcomes will be: 1.
- Trial name
- NCT00611442
- Testing
- lubiprostone
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Uterine Fibroids, Anemia
Safety and Efficacy of Proellex in Pre-menopausal Anemic Women With Symptomatic Uterine Fibroids
Eligible female subjects will be randomly assigned to one of the three treatment groups. Subjects will receive 325 mg (65 mg elemental iron) iron supplements to be taken twice daily during study drug treatment.
- Trial name
- NCT00702702
- Testing
- Proellex 25 mg, Proellex 50 mg
- Where
- 30 sites in United States
- Volunteers
- 56 people
- Sponsor
- Repros Therapeutics Inc.
Healthy
The Effects of Pre-Loaded Betaine Supplementation on Thermoregulation and Exercise Metabolism in the Heat
This will be a double blind, placebo-controlled, randomized, counterbalanced, crossover study designed to assess the impact of preloaded betaine supplementation on thermoregulation and exercise metabolism in the heat.
- Trial name
- NCT04585295
- Testing
- Betaine, BCAA Big 6
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Florida State University
Myocardial Infarction, Reperfusion Injury
Myocardial Infarction Size Reduction With Atorvastatin
The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as compared to placebo.
- Trial name
- NCT00286312
- Testing
- Atorvastatin
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- R&D Cardiologie
Pancreatic Cancer
Study of XNW28012 in Subjects With Metastatic Pancreatic Cancer Who Received Prior Systemic Therapy
This study was a randomized, double-blind, multicenter phase III clinical study. A total of 226 patients with metastatic pancreatic ductal carcinoma who had failed or were intolerant to two previous standard therapies were…
- Trial name
- NCT07823049
- Testing
- XNW28012 for injection, XNW28012 Mimetic for Injection
- Where
- 48 sites in China
- Volunteers
- 226 people
- Sponsor
- Evopoint Biosciences Inc.
Trauma, Massive Hemorrhage
Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC)
Severe traumatized patients with visible significant bleeding and/or with clinical signs of internal significant bleeding treated by an emergency doctor of the helicopter service or the ground team will be enrolled in the study…
- Trial name
- NCT01475344
- Testing
- Human Fibrinogen Concentrate
- Where
- 16 sites in Austria, Czechia and 1 more
- Volunteers
- 67 people
- Sponsor
- Medical University Innsbruck
Type 2 Diabetes Mellitus
Efficacy of add-on Therapy With Vildagliptin in Chinese Patients With Type 2 Diabetes Inadequately Controlled With Prior Metformin Monotherapy
The purpose of this study is to assess the efficacy and safety of vildagliptin 50 mg bid compared to placebo as an add-on therapy to metformin in Chinese patients with T2DM inadequately controlled by metformin alone.
- Trial name
- NCT00822211
- Testing
- Vildagliptin 50 mg bid, Vildagliptin 50 mg qd
- Where
- 17 sites in China
- Volunteers
- 404 people
- Sponsor
- Novartis
Burn Out, Psychological Disturbance
A Specialized Nutraceutical for Pre-burnout
High demands, professional overload and emotional stress are well known negative influences on mental health. Chronic stress-related occupational diseases, especially Burnout, are becoming an important issue.
- Trial name
- WELBI (NCT04532892)
- Testing
- Meta 18.06 Day and Meta 18.06 Night
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Herpes Zoster
Safety and Immunogenicity Study of GlaxoSmithKline's Herpes Zoster Subunit Vaccine (HZ/su) When Given on a Two-dose Schedule to Adults at Least 50 Years of Age (YOA) With a Prior Episode of Herpes Zoster
The purpose of this study was to assess the safety and immunogenicity of GSK Biologicals' HZ/su vaccine when given on a two-dose schedule to adults aged 50 years and above who had a previous episode of Herpes Zoster (HZ).
- Trial name
- NCT04091451
- Testing
- Herpes Zoster subunit (HZ/su) vaccine (GSK1437173A)
- Where
- 3 sites in Russia
- Volunteers
- 1,430 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain, Postoperative, Anesthesia
Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.
We propose a double-blind randomized controlled trial to evaluate the effect of intravenously administered morphine at surgery conclusion on acute postoperative pain in patients recovering from craniotomy surgery.
- Conditions
- Pain, Postoperative, Anesthesia, Analgesia
- Trial name
- NCT05117034
- Testing
- Morphine, Nacl 0.9%
- Where
- Israel
- Volunteers
- 115 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Depressive Disorder, Major
Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy
The proposed study is a randomized, placebo-controlled, double-blind trial to evaluate the safety and efficacy of antidepressant combination for the treatment of depression.
- Trial name
- COATS (NCT00150839)
- Testing
- Mirtazapine, Venlafaxine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Erlangen-Nürnberg Medical School