Clinical trials: Placental Development
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University
Pregnancy, Healthy
Effect of Physical Exercise Program on Fetoplacental Growth
The aim of this study is to examine the effect of a supervised physical exercise program during pregnancy on fetoplacental growth.
- Trial name
- NCT02420288
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Healthy
Placenta Development Study
This study will help us learn more about how the placenta develops.
- Trial name
- NCT03614312
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Preeclampsia
Second Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Placentation Disorders
The current study included the singleton pregnancies (without history of previous risk factors), had their homocysteine measured as part of a serum-screening program in addition to uterine artery Doppler.
- Trial name
- NCT02854501
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Placenta Diseases
Near-infrared Spectroscopy: Differences in Placental Oxygenation in Relation to Ultrasound Maturation Grade in physiologIcal Term Pregnancies
The aim was to compare placental oxygenation in low risk, uncompli-cated, term pregnancies measured by near-infrared spectroscopy (NIRS) in relation to the placental maturity grade determined by ultrasound assessment according to…
- Trial name
- NCT05771415
- Where
- Croatia
- Volunteers
- 34 people
- Sponsor
- University of Palermo
Obstetric Labor, Premature
Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
- Trial name
- NCT03211338
- Testing
- Culture with progesterone, Culture without progesterone, Culture with growth factors
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Premature Birth, Preeclampsia
A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders
This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture…
- Conditions
- Premature Birth, Preeclampsia, Fetal Growth Retardation, Stillbirth
- Trial name
- NCT02336243
- Testing
- Docosahexaenoic acid (DHA)
- Where
- 5 sites in Chile
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Iron Deficiency, Child Development
Infant Brain Study Follow-Up at 3 and 4 Years of Age
When immediate clamping of the umbilical cord (ICC) occurs at birth, 20 to 30% of the fetal-placental blood volume is left behind in the placenta.
- Trial name
- NCT02619006
- Testing
- Delayed Cord Clamping or Cord Milking
- Volunteers
- 10 people
- Sponsor
- University of Rhode Island
Placenta Accreta Spectrum, Abnormal Placentation
Effect of Methylene Blue Bladder Instillation on Urinary Tract Injuries During Cesarean Hysterectomy for Placenta Accreta Spectrum
This prospective cohort study aims to evaluate whether preoperative bladder filling with methylene blue dye can reduce the incidence of urinary tract injuries during cesarean hysterectomy in patients diagnosed with placenta…
- Conditions
- Placenta Accreta Spectrum, Abnormal Placentation, Cesarean Hysterectomy, Urinary Tract Injury
- Trial name
- NCT07129135
- Testing
- The bladder was filled with 300 ml diluted methylene blue (in normal saline) via Foley's catheter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Usama Ahmed Elsaeed Salem, MD
Iron Deficiency
Delayed Cord Clamping and Infant Brain Study
The purpose of this study is to determine if delaying cord clamping at the birth of term infants effects the early brain development (myelin deposition)as determined by quantitative MRI at 4 and 10 months and developmental…
- Trial name
- IBS (NCT01620008)
- Testing
- Delayed Cord Clamping
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Chorioamnionitis, Cerebral Palsy
Early Identification of Brain Insult in Chorioamnionitis
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus.
- Trial name
- NCT01778725
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Placenta; Implantation
Prospective Randomized Study to Evaluate the Effect of Embryonic Observation on the Gestation (PROdE)
In a conventional in vitro fertilization (IVF) cycle, daily microscopic observation of embryos outside the incubator to assess their morphology and establish a selection process is performed.
- Trial name
- PROdE (NCT02372279)
- Testing
- Embryo observation
- Where
- Spain
- Volunteers
- 193 people
- Sponsor
- Instituto Bernabeu
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up
An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking…
- Trial name
- CORDMILK-FU (NCT03682042)
- Testing
- Umbilical Cord Milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic