Clinical trials: Plaque Control, open to volunteers
Malocclusion
Evaluation of Clinical and Patient-Reported Outcomes of Laceback
The goal of this clinical trial is to evaluate oral hygiene status, archwire complications, laceback complications, and pain while using lacebacks in patients undergoing orthodontic fixed appliance treatment.
- Trial name
- NCT07039071
- Testing
- Laceback
- Where
- Malaysia
- Volunteers
- 38 people
- Sponsor
- International Islamic University Malaysia
Major Adverse Cardiovascular Events (MACE), Prevention
Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease
The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target…
- Conditions
- Major Adverse Cardiovascular Events (MACE), Prevention, Coronary Artery Disease(CAD), CT Angiography
- Trial name
- SUCCESS (NCT06843005)
- Testing
- Coronary Computed Tomography Angiography, Current clinical guidelines
- Where
- China
- Volunteers
- 3,100 people
- Sponsor
- Zhang longjiang,MD
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if screening and early treatment of mild heart disease works.
- Conditions
- Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control, Premature Atherosclerosis
- Trial name
- PRE-EMPT (NCT07232069)
- Testing
- Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- 23 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Duke University
Plaque Psoriasis Subjects
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of RSS0393 Ointment in Adult Patients With Plaque Psoriasis.
Phase III Efficacy and Safety Study of RSS0393 Ointment in Plaque Psoriasis.
- Trial name
- NCT07543224
- Testing
- RSS0393 ointment 0.03%
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Reistone Biopharma Company Limited
Peri-Implantitis, Plaque, Dental
Antibacterial Photodynamic Therapy in the Management of Peri-implantitis
This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term.
- Trial name
- NCT06017817
- Testing
- Lumoral Treatment, Standard oral hygiene instructions, Scaling and root planing (SRP
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Koite Health Oy
Intracranial Atherosclerosis, Intracranial Artery Stenosis
PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis
This is a prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial designed to evaluate the efficacy and safety of PCSK9 inhibitor combined with statin therapy compared to statin monotherapy in…
- Conditions
- Intracranial Atherosclerosis, Intracranial Artery Stenosis, Atherosclerotic Plaque
- Trial name
- PISTIAS-2 (NCT06902740)
- Testing
- Recaticimab and Statin, Statin
- Where
- 19 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease (CAD)
Colchicine Treatment for Non-Flow-Limiting Coronary Plaque by Coronary CTA: A Randomized Controlled Trial
This study is a prospective, multicenter, randomized controlled clinical trial designed to evaluate whether an anti-inflammatory medication can help improve heart health in patients with stable coronary artery disease. 1.
- Trial name
- COLOR (NCT07349875)
- Testing
- Colchicine combined with Guideline-Directed Medical Therapy
- Where
- China
- Volunteers
- 3,826 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gingivitis, Gingival Bleeding
Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush
This is a study to evaluate the safety and the efficacy of an electric flosser (interproximal cleaning aid), when used with a manual toothbrush, on gingivitis and dental plaque removal.
- Conditions
- Gingivitis, Gingival Bleeding, Dental Plaque
- Trial name
- NCT07779564
- Testing
- Electric Flosser, Manual Toothbrush
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Flaus, Inc
Plaque Psoriasis
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque Psoriasis
The purpose of this pediatric study is to evaluate the drug levels, efficacy and safety of Deucravacitinib in children and adolescent participants aged 4 to <18 years with moderate to severe plaque psoriasis.
- Trial name
- NCT04772079
- Testing
- Deucravacitinib
- Where
- 65 sites in Argentina, Australia and 11 more
- Volunteers
- 153 people
- Sponsor
- Bristol-Myers Squibb
Plaque Psoriasis
A Study to Evaluate the Efficacy and Safety of CS32582 in Participants With Moderate to Severe Plaque Psoriasis
" This study consists of two parts: Part 1 (Dose Escalation): A randomized, double-blind, placebo-controlled phase in which approximately 20 to 30 adult patients with plaque psoriasis will receive the investigational treatment…
- Trial name
- MECAP (NCT07129382)
- Testing
- CS32582 capsule（low dose）, CS32582 capsule（medium dose）, CS32582 capsule（high dose）
- Where
- 11 sites in China
- Volunteers
- 220 people
- Sponsor
- Chipscreen Biosciences, Ltd.
Plaque Control, Gingival Health
Sonic Toothbrush Versus an Oscillating-rotating Toothbrush on Plaque Control and Gingival Health
Objective:To evaluate the usefulness of a sonic toothbrush compared to an electric toothbrush for plaque removal and improving gingival health.Patients:Patients over 18 years of age who attend the Master's Degree in Medicine…
- Trial name
- SONICOR (NCT07651982)
- Testing
- sonic toothbrush
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Coronary Artery Disease, Optical Coherence Tomography
Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography
The presence of coronary atherosclerotic vulnerable plaque significantly impacts the clinical outcomes of patients diagnosed with coronary artery disease (CAD).
- Trial name
- NCT06520904
- Testing
- PCSK9 inhibitor, Statin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
Brief Description of Focus of Study
A Study of WD-890 in Participants With Moderate-to-Severe Plaque Psoriasis
Th purpose of the study is to evaluate the dose response of WD-890 in efficacy at Week 16 in participants with moderate-to-severe plaque psoriasis.
- Trial name
- NCT06912165
- Testing
- WD-890 tablet
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Zhejiang Wenda Pharma Technology LTD.
Gingivitis
Clinical Study Examining the Control of Plaque and Gingivitis
The objective of this six-month clinical investigation is to evaluate the efficacy of a silica-free meridol toothpaste versus Colgate Cavity Protection Toothpaste in the control of established dental plaque and gingivitis.
- Trial name
- NCT07842978
- Testing
- Silica Free Meridol, Meridol, Colgate Dental Product
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Plaque Induced Gingivitis, Toothbrushing
Clinical ,Microbiological and Compliance Outcomes of AI-based Toothbrushes in Plaque Induced Gingivitis
Severe periodontitis is widespread and begins with reversible gingivitis, driven by poor oral hygiene and a dysbiotic microbiome. Daily toothbrushing is the simplest prevention, but patients still leave plaque.
- Conditions
- Plaque Induced Gingivitis, Toothbrushing, Compliance
- Trial name
- NCT07308522
- Testing
- AI toothbrush, Manual toothbrush, Electric toothbrush
- Where
- Iraq
- Volunteers
- 33 people
- Sponsor
- University of Baghdad
Atherosclerotic Cardiovascular Disease, Acute Coronary Syndromes
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Followed by an Open-label Patient Cohort
The goal of this clinical trial is to learn if UDP-003 is safe in healthy human participants and patients, assess the pharmacokinetics (PK)/pharmacodynamics (PD) of UDP-003 in healthy human participants and patients and its…
- Trial name
- CTx-001 (NCT06813339)
- Testing
- UDP-003
- Where
- 3 sites in Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cyclarity Therapeutics, Inc.
Plaque Psoriasis
Efficacy and Safety of ICP-332 Versus Placebo in Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is to compare the efficacy and safety of ICP-332 to placebo in participants with moderate-to-severe plaque psoriasis.
- Trial name
- NCT07251998
- Testing
- ICP-332 Tablets
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Root Resorption, Plaque Accumulation
Comparison of Canine Retraction Using Ni-ti Closed-coil Springs Vs Elastomeric Power Chains During Orthodontic Treatment
The objective of this study is to compare the canine retraction rate (in mm with a 100 mm marked scale) using Ni-Ti closed-coil springs versus elastomeric power chains during canine retraction in subjects with first premolar…
- Conditions
- Root Resorption, Plaque Accumulation, Gingivitis
- Trial name
- NCT06567730
- Testing
- Ni-ti Closed-coil Spring, Elastomeric Power chain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Munnal Gulzar
Plaque Psoriasis
A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the efficacy, safety, and drug levels of Deucravacitinib (BMS-986165) in adolescent participants with moderate to severe plaque psoriasis
- Trial name
- POETYK-PsO-Ped (NCT06979453)
- Testing
- Deucravacitinib
- Where
- 133 sites in United States, Argentina and 14 more
- Volunteers
- 366 people
- Sponsor
- Bristol-Myers Squibb