Clinical trials: Plaque Reduction
Gingivitis, Periodontal Diseases
Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems
Although the well-known detrimental effects of conventional cigarette smoking on oral health, there are still lack of evidences about the impact of less harmful alternatives (such as electronic cigarettes or heat not burn…
- Trial name
- SMILE (NCT04649645)
- Testing
- TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS), NOT SMOKING
- Where
- Italy
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Eclat Srl.
Oral Hygiene, Toothbrushing
Open-label Trial Evaluating Four Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste, and Mouthwash
The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and…
- Conditions
- Oral Hygiene, Toothbrushing, Dental Plaque
- Trial name
- NCT05999175
- Testing
- the toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
- Where
- 2 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Biokosmes Srl
Gingivitis, Dental Plaque
Effect of Toothpaste on the Reduction of Plaque and Inflammation
The purpose of this double blind study is to prove whether a fluoride containing toothpaste is able to reduce dental plaque and gingival inflammation in patients who have gingivitis when applied twice daily during brushing at…
- Trial name
- NCT02552589
- Testing
- Amine fluoride
- Where
- Germany
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Gingivitis, Gingival Diseases
Effectiveness in Dental Plaque Reduction of Mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous Fluoride
Comparative study on the efficacy of two mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous Fluoride in the reduction of plaque score in individuals with spontaneous gengivitis
- Trial name
- NCT04977778
- Testing
- Fatty Acids Compounds (F.A.G.) Mouthwash, Stannous Fluoride (SF) Mouthwash
- Where
- Italy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Coronary Artery Disease
Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy
The study will assess the regression of yellow plaque content of the lipid pool after aggressive lipid therapy by utilizing NIR spectroscopy.
- Trial name
- YELLOW (NCT01567826)
- Testing
- standard of care lipid therapy, Aggressive lipid therapy
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Annapoorna Kini
Gingivitis
Comparing the Inter-dental Brush to Dental Floss
The study's purpose is to find an easy and effective alternative to dental floss for those persons who cannot or choose not to dental floss so that they can maintain and/or achieve optimal oral health.
- Trial name
- NCT00743548
- Testing
- IB = Interdental brush, the intervention, DF = Dental floss, the positive control
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dental Caries
SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children
This randomized split-mouth clinical trial will compare the effectiveness of 38% silver diamine fluoride (SDF) versus 5% sodium fluoride varnish (FV) in reducing salivary Streptococcus mutans levels in children with bilateral…
- Trial name
- Streptococcus (NCT07181967)
- Testing
- Sodium Fluoride Varnish (5%), Silver Diamine Fluoride (38%)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Assiut University
Gingivitis
Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste
The objective of this study is to evaluate the clinical efficacy of a toothpaste containing stannous fluoride as compared to Colgate Fluoride Toothpaste in reducing plaque and gingivitis - a three- month study.
- Trial name
- CP_Total (NCT04033575)
- Testing
- Colgate Total SF, Colgate Cavity Protection toothpaste
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Plaque
Safety and Efficacy of the ToothWave -12 Weeks Calculus Study
The objective of the study is to evaluate the safety and efficacy of the home-use device Silk'n toothbrush (ToothWave) for the improvement in dental health through the reduction of plaque, gingivitis, and calculus.
- Conditions
- Gingivitis, Plaque, Calculus, Dental
- Trial name
- NCT04092075
- Testing
- RF-utilizing powered toothbrush
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Gingival Bleeding, Plaque Induced Gingival Disease
Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction
Clinical study evaluating the effectiveness of an alcohol-free mouthwash containing CPC+Zn compared to dental flossing and an essential oils-containing alcohol mouthwash in reducing dental plaque and gingivitis.
- Conditions
- Gingival Bleeding, Plaque Induced Gingival Disease, Gingivitis and Periodontal Diseases
- Trial name
- PGMWI (NCT06607263)
- Testing
- Mouthwash CPC+Zn+F, Essential oils mouthrinse, Dental floss
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Colgate Palmolive
Cardiovascular Disease
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).
- Trial name
- OCEAN(a)-CCTA (NCT07293260)
- Testing
- Olpasiran
- Where
- 40 sites in United States, Australia and 9 more
- Volunteers
- 406 people
- Sponsor
- Amgen
Hyperlipidemia, Coronary Artery Disease
Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume
This multicentre, open-label, single-arm Study is to evaluate the effect of Rosuvastatin 20 mg 76 weeks on coronary atherosclerosis plaque versus baseline in Chinese coronary heart disease (CHD) patients with hyperlipidemia by…
- Trial name
- REDUCT (NCT01382277)
- Testing
- Rosuvastatin
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Peking University First Hospital
Dental Plaque, Gingivitis
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens
The objective of this twelve-week clinical research study is to assess the efficacy of two brushing regimens: 1) toothpaste with mouthwash containing sodium fluoride/zinc and manual toothbrush as compared to 2) regular fluoride…
- Trial name
- NCT06240481
- Testing
- Test Regimen, Control Regimen
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Good Health, Gingival Inflammation and Bleeding
Oil Pulling Reduction
The goal of this study is to scientifically evaluate the efficacy of this oil pulling oral rinse in reducing dental plaque, gingival inflammation, gingival bleeding, and selectively reducing caries- and periodontal…
- Conditions
- Good Health, Gingival Inflammation and Bleeding, Dental Plaque
- Trial name
- NCT07706647
- Testing
- GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Toothbrushing, Periimplant Diseases
Manual Versus Sonic-powered Toothbrushing for Plaque Reduction in Patients with Peri-implant Mucositis
Aim: To compare the effect of manual and sonic-powered toothbrushing on biofilm control in patients with peri-implant mucositis.
- Trial name
- NCT06800625
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University
Plaque, Dental Plaque
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores.
- Conditions
- Plaque, Dental Plaque, Gingivitis
- Trial name
- NCT07842991
- Testing
- 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis
The objective of this clinical research study is to evaluate the efficacy of floss to an essential oil alcohol-containing mouthwash, an essential oil alcohol-free mouthwash, and a CPC+Zn alcohol-free mouthwash in reducing dental…
- Trial name
- NCT07029438
- Testing
- Mouthwash, Floss, Toothbrush
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Bleeding, Dental Plaque Accumulation
Adjunctive Oral Hygiene Aids in Reducing Oral Hygiene Parameters Among Orthodontic Patients
Adult orthodontic patients aged 18-30 were included in a randomised, singleblind clinical research using a split-mouth design at a dental clinic.
- Trial name
- D-F-H-17-Dec (NCT06779279)
- Testing
- Water flosser and super flosser, Orthodontic brush
- Where
- United Arab Emirates
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- sudhir rama varma
Cardiovascular Disease
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction
Background: Coronary artery disease causes plaque in arteries. This can cause stroke or heart disease. Drugs called statins might shrink plaque.
- Trial name
- NCT02740699
- Testing
- Rosuvastatin, Atorvastatin, Cardiac Computed Tomography (CT)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Gingivitis, Plaque
Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.
The objective of this six-month clinical research study is to evaluate the clinical efficacy of two dentifrices - Toothpaste containing zinc lactate and Colgate Cavity Protection Toothpaste in reducing gingivitis and dental…
- Trial name
- NCT06563518
- Testing
- Meridol, Colgate Cavity Protection
- Where
- Thailand
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive