Clinical trials: Plasma Volume, open to volunteers
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute on Chronic Liver Failure (ACLF)
Very Low-volume Plasma Exchange in ACLF
This is a prospective, multicenter, open-label, non-inferiority, randomized controlled trial evaluating the efficacy and safety of very low plasma exchange (400 mL plasma + prothrombin complex concentrate) and plasma-free…
- Trial name
- VLPE-ACLF (NCT07857434)
- Testing
- Double Plasma Molecular Adsorption System (DPMAS), Low-volume plasma exchange, Prothrombin Complex Concentrate (PCC)
- Volunteers
- 840 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Sleep Deprivation
Effects of Partial Sleep Deprivation on Cardiac Output During Cycling
The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50…
- Trial name
- NCT06679543
- Testing
- Partial sleep deprivation
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Acute Liver Failure, Cerebral Edema
High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial Investigator aim to evaluate the impact of high versus standard volume plasma-exchange in patients with acute liver failure with cerebral edema and clinical outcomes.
- Trial name
- NCT06515145
- Testing
- High Volume Therapeutic Plasma Exchange, Standard volume therapeutic plasma exchange
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Liver Failure
Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure
Acute liver failure is a multisystem disorder characterized by a syndrome of jaundice, coagulopathy, and encephalopathy with high mortality in the absence of liver transplantation.
- Trial name
- NCT06831643
- Testing
- Standard Medical treatment, Therapeutic Plasma Excahnge
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Colorectal Cancer, Urologic Cancer
Fluid Challenge and Plasma Volume, During Surgery
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique.
- Conditions
- Colorectal Cancer, Urologic Cancer, Gynecologic Cancer, Colorectal Disorders
- Trial name
- FC-VE (NCT05726136)
- Testing
- acetated Ringers, albumin 5%, albumin 20%
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Joachim Zdolsek
Burn Injury, Thermal Burn
Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial
The Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) trial will be a 5-year (3-year enrollment), open label, phase-3, multi-center, early in-hospital phase randomized trial…
- Trial name
- PREEVEnT (NCT07212998)
- Testing
- Plasma, Standard care
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Jason Sperry
Heat Exposure, Exercise Performance
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes.
- Conditions
- Heat Exposure, Exercise Performance, Hydration, Body Fluid Compartments
- Trial name
- NCT07593014
- Testing
- Creatine Monohydrate
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Windsor
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT