Clinical trials: Plasmodium Falciparum
Falciparum Malaria
Biological Mechanisms in Afebrile P. Falciparum Malaria
This project aims to disentangle the role of host immune resistance and disease tolerance in afebrile malaria infections, with the goal of guiding context-adapted tactics to target this hidden reservoir, as well as to develop new…
- Trial name
- AsintMal (NCT04422015)
- Testing
- No intervention
- Where
- Mozambique
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Alfredo Mayor
Malaria,Falciparum
Safety and Immunogenicity of SUM-101 Malaria Vaccine in Children and Infants Living in Burkina Faso
This clinical trial aims to learn about the safety and immunogenicity of the blood-stage malaria vaccine candidate SUM-101 in infants and children, paving the way for its incorporation into a multi-stage malaria vaccine.
- Trial name
- SUM-101 (NCT06618885)
- Testing
- SUM-101
- Where
- Burkina Faso
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria
Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)
This is an initial efficacy study of a candidate antimalarial in human subjects with uncomplicated malaria caused by the most common and most important parasite in Africa (Plasmodium falciparum).
- Trial name
- NCT01614964
- Testing
- AQ-13 Treatment, Coartem Treatment
- Where
- Mali
- Volunteers
- 66 people
- Sponsor
- Tulane University
Malaria
Efficacy and Safety of Artemisinin-based Combination Treatments in the Democratic Republic of the Congo
The Democratic Republic of the Congo (DRC) is among the countries most affected by malaria in Sub-Saharan Africa. Condidering its size and the geographic position, the DRC is meant to play a major role in the malaria control in…
- Trial name
- TETRDC2016 (NCT02940756)
- Testing
- artesunate-amodiaquine, artemether-lumefantrine, Dihydroartemisinine-piperaquine
- Where
- 6 sites in Democratic Republic of the Congo
- Volunteers
- 1,615 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Malaria
Safety and Efficacy of Recommended Antimalarial in the Democratic Republic of the Congo
Despite all efforts, malaria remains a public health concern, in particular in the Democratic Republic of the Congo (DRC). The National Malaria Control program recommends artemisinin-based combination treatments (ACTs), in…
- Trial name
- TET2020 (NCT04618523)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 6 sites in Democratic Republic of the Congo
- Volunteers
- 1,117 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Malaria
Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria.
To compare Azithromycin plus Chloroquine versus Mefloquine to treat uncomplicated plasmodium falciparum malaria.
- Trial name
- NCT00367653
- Testing
- Azithromycin plus Chloroquine, Mefloquine
- Where
- 8 sites in Burkina Faso, Ghana and 4 more
- Volunteers
- 397 people
- Sponsor
- Pfizer
Plasmodium Falciparum Malaria
Pharmacokinetics, Safety, Tolerability and Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium Falciparum Malaria
The purpose of this study was to evaluate PK, safety, tolerability and efficacy of a new formulation of artemether-lumefantrine dispersible tablet in neonates and infants <5 kg body weight with acute uncomplicated Plasmodium…
- Trial name
- CALINA (NCT04300309)
- Testing
- artemether:lumefantrine (2.5 mg:30 mg)
- Where
- 3 sites in Burkina Faso, Democratic Republic of the Congo
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Malaria,Falciparum
Pyramax in Asymptomatic Carriers of P. Falciparum Monoinfections
This study will assess the efficacy of Pyramax administered for three-day, two-day or one day, in clearing a P. falciparum infection in asymptomatic carriers. .
- Trial name
- NCT03814616
- Testing
- Pyronaridine tetraphosphate 180mg:artesunate 60mg
- Where
- 2 sites in The Gambia, Zambia
- Volunteers
- 300 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Malaria,Falciparum, Feasibility
Malaria Vaccine Pilot Evaluation
The RTS,S/AS01 malaria vaccine is being introduced sub-nationally in phased pilot introductions through the EPI programmes in Malawi Ghana and Kenya.
- Conditions
- Malaria,Falciparum, Feasibility, Safety, Mortality
- Trial name
- MVPE (NCT03806465)
- Testing
- Feasibility survey, Sentinel hospital surveillance, Community mortality surveillance
- Where
- 3 sites in Ghana, Kenya and 1 more
- Volunteers
- 30,124 people, healthy volunteers welcome
- Sponsor
- Rafiq OKINE
Plasmodium Falciparum Malaria (Drug Resistant)
Drug Combinations of Atovaquone-Proguanil (AP) With ACT
Investigators are conducting this study due to recent reports of many of existing malaria drugs becoming less effective for treatment of malaria.
- Trial name
- APACT (NCT03726593)
- Testing
- Artesunate and Pyronaridine, Atovaquone Proguanil and Artesunate Pyronaridine, Atovaquone Proguanil and Artesunate Mefloquine
- Where
- 3 sites in Cambodia
- Volunteers
- 252 people
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Malaria,Falciparum
A Pharmacokinetic/Pharmacodynamic Study of Eurartesim Dispersible Formulation in Infants With P.Falciparum Malaria
There is a need for paediatric formulations that permit accurate dosing and enhance patient compliance. However, for the treatment of malaria, scarce paediatric-friendly formulations are available on the market.
- Trial name
- NCT01992900
- Testing
- Eurartesim dispersible oral tablet, eurartesim film coated tablet
- Where
- 7 sites in Burkina Faso, Democratic Republic of the Congo and 3 more
- Volunteers
- 300 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Malaria
Investigation of the Efficacy of Quinine Sulphate Administered Via Taste-Masked Pellets to Children With Falciparum Malaria
No pediatric formulations of quinine exist. Therefore, quinine tablets are broken into 2 or 4 parts, according to the body weight. Based on the body weight, 1/2 or 1/4 a tablet is administered to the child.
- Trial name
- NCT00329134
- Testing
- Administration of quinine sulphate taste-masked pellets
- Where
- Rwanda
- Volunteers
- 56 people
- Sponsor
- University Ghent
Malaria,Falciparum
Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention
In areas of the Sahel sub-region of Africa with intense seasonal malaria transmission, seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP+AQ) has become the standard-of-care for the…
- Trial name
- DRUMARS (NCT04969185)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 310 people
- Sponsor
- University of California, San Francisco
Malaria,Falciparum
Safety, Pharmacokinetics, and Plasmodium Falciparum Transmission-reducing Activity of Monoclonal Antibody TB31F in Mali
Mali faces a significant challenge with malaria, particularly among its younger population. While existing measures like seasonal chemoprevention and vaccination have shown efficacy, further innovations are necessary to combat…
- Trial name
- NCT06413108
- Testing
- TB31F, Normal saline
- Where
- Mali
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum
Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.
This is a household randomized trial of a new tool for house modification, Insecticide-Treated Eave nets (ITENs) in combination with insecticide-treated window screens (ITWS), coated with a dual active ingredient (dual AI)…
- Trial name
- ITENs (NCT05125133)
- Testing
- ITENs + ITWS
- Where
- Tanzania
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Ifakara Health Institute
Plasmodium Falciparum, Malaria
DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria
Study to evaluate the efficacy of DSM265 as a causal prophylactic in a standardized and validated Human Challenge model using direct venous inoculation of aseptic, purified, cryopreserved, vialed Plasmodium falciparum sporozoites.
- Trial name
- NCT02450578
- Testing
- DSM265 400mg, Plasmodium falciparum sporozoite challenge, Malarone
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria in Pregnancy, Birth Weight
Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance
Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease.
- Conditions
- Malaria in Pregnancy, Birth Weight, Anaemia
- Trial name
- NCT00140517
- Testing
- sulphadoxine-pyrimethamine, chloroquine
- Where
- Burkina Faso
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Falciparum
Food Interaction Study on the Pharmacokinetics of Eurartesim™ (DHA and PQP)in Healthy Male Adult Volunteers
The study was designed to assess the effect of food on the extent and rate of absorption of Dihydroartemisinin (DHA) and Piperaquine Phosphate (PQP) administered as a fixed dose combination (Eurartesim™).
- Trial name
- NCT01222962
- Testing
- Eurartesim
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- sigma-tau i.f.r. S.p.A.
Malaria
Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes
Study designed to evaluate safety and tolerability of a genetically attenuated P. falciparum (GAP3KO) that arrests early in the liver stage of the parasite life cycle.
- Trial name
- NCT02313376
- Testing
- GAP3KO
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Malaria, Malaria,Falciparum
Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC)
Seasonal Malaria Chemoprophylaxis (SMC) is a fundamental component of malaria control. The SMC program involves that sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) is given to children below the age of 5 years during the peak…
- Trial name
- INDIE-SMC (NCT05878366)
- Testing
- Seasonal Malaria Chemoprophylaxis (under 5 year old) implemented by the MoH without DOT, Seasonal Malaria Chemoprophylaxis (under 5 years old) with DOT, Seasonal Malaria Chemoprophylaxis (under 10 years old) with DOT
- Where
- Burkina Faso
- Volunteers
- 2,978 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine