Clinical trials: Platelet
Chronic Kidney Diseases
Appropriate Duration of Anti-Platelet straTegy in Patients With Advance Chronic Kidney Disease After New Generation Drug Eluting Stents (ADAPT-CKD)
The purpose of this prospective randomized clinical trial is to compare the clinical outcomes according to the duration of aspirin and clopidogrel or prasugrel with dual anti-platelet therapy after percutaneous coronary…
- Trial name
- NCT04708587
- Testing
- dual anti-platelet therapy at least 6 months, dual anti-platelet therapy 3months or less
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Yonsei University
Liver Cirrhosis, Coagulation Disorder
Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes
Rifaximin is an antibiotic that acts locally in the gastrointestinal tract with a broad spectrum of antibacterial activity. The efficacy of rifaximin is well documented in the prevention of acute hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Coagulation Disorder, Platelet Disorder, Endotoxemia
- Trial name
- NCT06630572
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Solid Tumor, Solid Tumor, Childhood
A Study of Romiplostim to Prevent Low Platelet Counts in Children and Young Adults Receiving Chemotherapy for Solid Tumors
The purpose of this study is to find out whether romiplostim can help prevent low platelet counts caused by N8 or EFT chemotherapy, reduce the number of platelet transfusions required during chemotherapy, and prevent treatment…
- Conditions
- Solid Tumor, Solid Tumor, Childhood, Solid Carcinoma
- Trial name
- NCT04671901
- Testing
- Romiplostim
- Where
- 7 sites in United States
- Volunteers
- 2 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anastomotic Leak, Platelet-Rich Fibrin
Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomosis
Anastomotic leak rate in colorectal surgery is estimated between 4 and 20 percent. Leukocyte and and platelet-rich fibrin plasma (L-PRF) is second generation platelet concentrate whose application in colorectal anastomosis in…
- Conditions
- Anastomotic Leak, Platelet-Rich Fibrin, Colorectal Surgery
- Trial name
- NCT05264467
- Testing
- Platelet rich fibrin on colorectal anastomosis
- Where
- Chile
- Volunteers
- 106 people
- Sponsor
- Universidad de Concepcion
Cardiovascular Diseases
In Vitro Interaction Between Ticagrelor and Its Active Metabolite and Their Effects on Salicylic Acid
This is a in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor and its active metabolite (AR-C124910XX) and their effects on the pharmacodynamics of salicylic acid.
- Trial name
- In_vitro_PAT (NCT01777516)
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Knee Osteoarthritis
Platelet-rich Plasma Intra-articular Knee Injections for Knee Osteoarthritis
The benefit of using platelet rich plasma (PRP) in cartilage injuries, and specifically in degenerative ones, has not been assessed yet.
- Trial name
- NCT01381081
- Testing
- platelet-rich plasma, Corticosteroid
- Where
- Spain
- Volunteers
- 74 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES)
A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)
The purpose of this study is to investigate the tolerability of ianalumab (9 mg/kg) with investigator's choice thrombopoietin receptor agonist (IC TPO-RA) in participants diagnosed with primary immune thrombocytopenia (ITP) who…
- Trial name
- VAY2EXPLORE (NCT07421167)
- Testing
- ianalumab, thrombopoietin receptor agonist (TPO-RA)
- Where
- 19 sites in United States
- Volunteers
- 164 people
- Sponsor
- Novartis Pharmaceuticals
Gingival Recession
Evaluation of the Modified VISTA Technique Using ALB-PRF vs CTG in the Treatment of Multiple Miller Class III Recessions
treatment of miller class III RT2 gingival recession using modified vista technique using connective tissue graft vs albumin PRF
- Trial name
- NCT06643507
- Testing
- Connective tissue graft, ALB-PRF
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease
Reversal of the Anti-platelet Effects of Ticagrelor
The purpose of this study is to determine the proportion of untreated donor platelets required to fully reverse the platelet inhibitory effects of ticagrelor and aspirin in healthy persons and patients with coronary artery…
- Trial name
- REVERSAL (NCT02383771)
- Testing
- Ticagrelor, Aspirin + Ticagrelor, Control
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atypical Hemolytic Uremic Syndrome
Ravulizumab Outcomes in Polish Patients With aHUS
This multicenter, observational cohort study uses retrospective collection of past medical history and prospective follow-up to capture longitudinal data on the management and clinical outcomes of patients with atypical hemolytic…
- Trial name
- aHUS-OPTIMUM (NCT07399730)
- Testing
- Ravulizumab
- Where
- 10 sites in Poland
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical
Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium
Thrombotic microangiopathy (TMA) is a severe and life-threatening condition, often affecting the kidneys and brain. It can occur on the background of various clinical conditions.
- Conditions
- Thrombotic Microangiopathies, Hemolytic Uremic Syndrome, Atypical, Hemolytic-Uremic Syndrome
- Trial name
- COMPETE (NCT04745195)
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Periodontitis
Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels
Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.
- Trial name
- NCT05178771
- Testing
- Platelet rich fibrin
- Where
- Iraq
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Primary Immune Thrombocytopenia (ITP)
rhTPO Dose Escalation vs Eltrombopag Switch in ITP
This study is a prospective, multicenter, randomized controlled study, planning to enroll 110 ITP patients who failed to respond to conventional-dose rhTPO (300 IU/kg/d) after 14 days of treatment (PLT < 30×10⁹/L).
- Trial name
- NCT07476846
- Testing
- Recombinant Human Thrombopoietin（rhTPO）, Eltrombopag PfOS
- Volunteers
- 112 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Cardiovascular Disease
Effect of Wine Consumption on Cardiovascular Markers in CHDs Patients
Many epidemiological studies support that 20-30gr of alcohol consumption per day is related with lower risk for cardiovascular diseases, heart attack as well as mortality related to these diseases.
- Trial name
- NCT04438122
- Testing
- Cabernet Sauvignon, Tsipouro
- Where
- Greece
- Volunteers
- 57 people
- Sponsor
- Harokopio University
Head and Neck Cancer
Free Skin Grafting to Reconstruct Donor Sites After Radial Forearm Flap Harvesting
Reconstruction of the donor site after radial forearm flap harvesting is a common procedure in maxillofacial plastic surgery. Unfortunately, free skin graft transplantation faces wound healing impairments such as necrosis…
- Trial name
- NCT05137639
- Testing
- Platelet-rich fibrin (PRF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Wound Healing, Pain, Postoperative
Evaluation of the Effects of Platelet Rich Fibrin on the Palatal Mucosal Healing
Subepithelial connective tissue graft (SCTG) has greater predictability for root coverage and causes minimal discomfort to patient.
- Conditions
- Wound Healing, Pain, Postoperative, Bleeding Wound
- Trial name
- NCT03734328
- Testing
- connective tissue graft, connective tissue graft&PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Tooth Socket
Immediately Placed Implant Sealed With Platelets Rich Fibrin Versus Cyanoacrylate Glue
The health of peri-implant soft tissues is one of the most important aspects necessary for the long-term survival of dental implants.
- Trial name
- NCT05437744
- Testing
- Cyanoacrylate glue, Platelet-rich fibrin (PRF)
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Myocardial Infarction, STEMI
Early Thienopyridine Treatment to Improve Primary PCI in Patients With Acute MI
Acute myocardial infarction is generally caused by a thrombotic occlusion of coronary arteries. Primary aim of early therapy is a fast and complete reperfusion of the infarcted myocardium.
- Trial name
- ETAMI (NCT01327534)
- Testing
- Prasugrel, Clopidogrel
- Where
- 3 sites in France, Germany
- Volunteers
- 63 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Thrombocytopenia, Cytarabine Causing Adverse Effects in Therapeutic Use
Avatrombopag for the Primary Prevention of Thrombocytopenia Induced by Cytarabine-based Chemotherapy in Patients With Lymphoma
This phase 2 trial studies the efficacy and safety of Avatrombopag for the primary prevention of thrombocytopenia induced by cytarabine-based chemotherapy in patients with lymphoma
- Conditions
- Thrombocytopenia, Cytarabine Causing Adverse Effects in Therapeutic Use, Lymphoma
- Trial name
- NCT04797182
- Testing
- avatrombopag
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sun Yat-sen University