Clinical trials: Platelet Disorder
Atypical Hemolytic-Uremic Syndrome
An Open-label, Multi-center Clinical Trial of Eculizumab in Adult Patients With Atypical Hemolytic-uremic Syndrome
The record Primary purpose is to assess the efficacy of eculizumab in adult patients with Atypical Hemolytic- Uremic Syndrome (aHUS) to control Thrombotic Microangiopathy (TMA) as characterized by thrombocytopenia, hemolysis and…
- Trial name
- NCT01194973
- Testing
- Eculizumab
- Where
- 23 sites in United States, Belgium and 5 more
- Volunteers
- 44 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Coronary Artery Disease
A Prospective muLticEnter Registry in chrONic coronARy synDrOme
In patients with chronic coronary syndrome (CCS), clopidogrel has a class I/A indication in patients undergoing elective percutaneous coronary intervention (PCI).
- Trial name
- LEONARDO (NCT06198673)
- Testing
- Antiplatelet Agents
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Myelofibrosis
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermediate-2 or high-risk Myelofibrosis (MF) who are relapsed/refractory (R/R) to…
- Trial name
- NCT04576156
- Testing
- Imetelstat, Best Available Therapy (BAT)
- Where
- 144 sites in United States, Argentina and 24 more
- Volunteers
- 327 people
- Sponsor
- Geron Corporation
Chronic Asthma
The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma
Cysteinyl leukotrienes (cys-LTs) are lipid inflammatory mediators that abound in mucosal inflammation and play a validated role in the pathogenesis of human asthma.
- Trial name
- PRINA (NCT01305369)
- Testing
- Prasugrel
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Milan
Anosmia, COVID-19
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6…
- Trial name
- NCT05226546
- Testing
- Platelet rich plasma (PRP), olfactory training
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Myelofibrosis
A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis
The main aim of this study is to learn how safe elritercept is and how well it is tolerated when taken alone and in combination with the JAK inhibitor, ruxolitinib.
- Trial name
- NCT05037760
- Testing
- Elritercept, Ruxolitinib
- Where
- 46 sites in Australia, Brazil and 5 more
- Volunteers
- 135 people
- Sponsor
- Takeda
Gingival Recession
Platelet Rich Fibrin in the Treatment of Palatal Wounds
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the epithelialized connective tissue graft palatal donor site healing acceleration and in the patient's morbidity reduction.
- Trial name
- NCT02438046
- Testing
- Palatal wound bandage
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Fistula in Ano
PRP Use in Treatment of Fistula Ano
In treatment of perianal fistula several methods are described. However, since the Hippocrates basics of surgical treatment has not changed very much.
- Trial name
- NCT04187651
- Testing
- platelet rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uşak University
Aortic Valve Stenosis
Platelet Adhesion in the Pathobiology of Aortic Stenosis
Aortic stenosis (AS) is a serious and common condition that affects 2-3% of the population >65 years of age in Western countries.
- Trial name
- NCT05550896
- Testing
- Echocardiogaphy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Virginia
ITP - Immune Thrombocytopenia
Exploring the Efficacy, Safety of a Modified Starting Dosage of Avatrombopag in Immune Throbocytopenia (ITP) - a Pilot Study
This is a single-center, open label pilot trial where patients with primary ITP who require second line treatment will be offered avatrombopag at a reduced starting dose, adjusted thereafter according to the response and…
- Trial name
- Ava dosing (NCT07133659)
- Testing
- Avatrombopag 20 mg Oral Tablet
- Where
- Iraq
- Volunteers
- 25 people
- Sponsor
- Al-Mustansiriyah University
Thrombocythemia Essential
Prospective Study of Different Biological Tests (Multiplate, ROTEM) in a Cohort of Patients Followed for Essential Thrombocytemia (ET)
There is no prospective study published on the Essential Thrombocythemia and the correlation between this specific disease, its complications and the biological variations observed.
- Trial name
- THETE (NCT03212053)
- Testing
- biological tests of haemostasis at each consultation (Multiplate, ROTEM, VASP)
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Hospices Civils de Lyon
Bleeding Disorder
Screening for Bleeding Disorders in Children
The investigators try to improve the screening of bleeding disorders in children by identifying symptoms, laboratory abnormalities and clinical scores discriminating patients congenital bleeding disorders in order to create a…
- Trial name
- NCT05214300
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Montpellier
Diabetic Foot Ulcer
A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers
Foot ulcers represent a significant common complication in patients with diabetes. Wound healing is a challenge. Some wounds do not respond to the best practices in wound care.
- Trial name
- NCT00338702
- Testing
- Autologous Platelet Gel
- Where
- Canada
- Sponsor
- Unity Health Toronto
Androgenetic Alopecia (AGA)
Clinical Study of PRP in the Treatment of Androgenetic Alopecia
A study on the therapeutic effect of platelet-rich plasma in the treatment of androgenetic alopecia
- Trial name
- NCT07551271
- Testing
- PRP
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Platelet Aggregation Onhibitors
The Laboratory AntiPlatelet Efficacy and Clinical Outcome Registry
The ongoing LAPCOR (Laboratory AntiPlatelet efficacy and Clinical Outcome Registry) registry was initiated in 2008 at a tertiary care cardiac center, and consecutive patients, who underwent intracoronary stent implantation, have…
- Trial name
- LAPCOR (NCT02264912)
- Testing
- antiplatelet drugs - P2Y12 antagonists
- Where
- Czechia
- Volunteers
- 2,016 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Cardiovascular Diseases, Acute Coronary Syndrome
Testing P2Y12 Platelet Inhibitors Generics Beyond Bioequivalence
This is a pilot study that was conducted to prove the efficacy and safety of ticagrelor generically named Ticaloguard® compared to its brand Brilique® in healthy volunteers.
- Trial name
- NCT05474053
- Testing
- Ticagrelor 90mg (Brilique), Ticagrelor 90mg (Ticaloguard)
- Where
- Egypt
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myocardial Infarction, Acute
Cilostazol and Endothelial Progenitor Cell
To assess impact of adjunctive cilostazol on endothelial progenitor cell (EPC) mobilization in patients with acute myocardial infarction (To reveal the role of cilostazol in up-regulation of EPC count)
- Trial name
- EPISODE (NCT04407312)
- Testing
- Cilostazol Tablets, Aspirin, Clopidogrel
- Volunteers
- 60 people
- Sponsor
- Gyeongsang National University Hospital
Thrombopenia, Cervical Cancer
Herombopag for the Prevention of Radio-chemotherapy Induced Thrombocytopenia in Cervical Cancer
Exploring and evaluating the efficacy of herombopag in preventing thrombocytopenia due to radiotherapy for cervical cancer
- Conditions
- Thrombopenia, Cervical Cancer, Radiotherapy Side Effect, Chemotherapeutic Toxicity
- Trial name
- NCT06745219
- Testing
- herombopag
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Cancer Hospital & Institute
Idiopathic Thrombocytopenic Purpura, Immune Thrombocytopenia
Lusutrombopag in the Treatment of Immune Thrombocytopenia (ITP)
This exploratory study is to investigate the efficacy, safety and tolerability of Lusutrombopag in the treatment of primary immune thrombocytopenia in Chinese patients who have failed first-line therapy
- Trial name
- NCT06287567
- Testing
- Lusutrombopag Oral Tablet
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Coronary Artery Disease
Clopidogrel and Response Variability Investigation Study 2
To evaluate the role of the genetic variant 2C19*2 on the pharmacodynamic response as assessed by optical aggregometry and on the pharmacokinetic response as assessed by measuring active metabolites following an oral…
- Trial name
- CLOVIS2 (NCT00822666)
- Testing
- clopidogrel
- Where
- France
- Volunteers
- 109 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris