Clinical trials: Platelet Transfusion
Cardiac Disease, Cardiac Surgery
Platelet Transfusion During Neonatal Open Heart Surgery
Hypothesis: Dilutional thrombocytopenia after cardiopulmonary bypass (CPB) is universal and administration of donor apheresis platelets just prior to termination of bypass will assist in early correction of coagulopathy, early…
- Conditions
- Cardiac Disease, Cardiac Surgery, Cardiopulmonary Bypass, Platelet Transfusion
- Trial name
- CPB (NCT03045068)
- Testing
- Platelet Transfusion, FFP and Cryoprecipitate, PRBC and cell saver Transfusion
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The University of Texas Health Science Center, Houston
Platelet Transfusion Refractoriness, Acute Leukemia in Remission
Sequential Infusion of CD19 and BCMA CAR-T Cells to Improve PTR in Patients With AL
Alloimmune-mediated platelet transfusion refractoriness(PTR) was usually caused by repeated blood transfusions and pregnancy and accounts for about 20-25% of PTR patients.
- Trial name
- NCT04846439
- Testing
- CAR-T infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Platelet Transfusion, Hematological Malignancy
Comprehensive Study of Social Representation of Platelet Transfusion in Patients Followed for Advanced Hematological Malignancies (R-PLQ)
Limited data is available for end of life care in hematologic malignancies, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its…
- Conditions
- Platelet Transfusion, Hematological Malignancy, Palliative Care
- Trial name
- R-PLQ (NCT03806712)
- Testing
- multi method questionary (developped by De Rosa, in 1995 and 2014)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Platelet Transfusion, Critical Illness
Platelet Transfusions in Critically Ill Patient
Between 10 and 15% of critically ill patients require platelet transfusion within their intensive care unit (ICU). Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat bleeding as part of massive…
- Trial name
- RE-CCIP (NCT03325140)
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Platelet Transfusion, Palliative Care
Retrospective Descriptive Study of Platelet Transfusion in Patients With Palliative Hematologic Malignancies at the University Hospital of Besançon
Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients.
- Trial name
- NCT03814486
- Testing
- descriptive
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Platelet Transfusion
Cold Apheresis Platelets in PAS
This is a platelet transfusion study. The purpose of this study is to measure the life span and quality of platelets stored in a refrigerator. Participants will give platelets by apheresis.
- Trial name
- CAPP (NCT02754414)
- Testing
- Apheresis platelet collection, Refrigerated storage of apheresis platelets in PAS/plasma, Infusion of aliquot of autologous radiolabeled platelets
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Neonatal Thrombocytopenia, Intraventricular Hemorrhage
Monitoring Outcome in Neonatal Thrombocytopenia
Rationale: Approximately 10% of neonates admitted to neonatal intensive care units develop a major hemorrhage. In an attempt to avert this severe complication various preventive measures have been implemented.
- Conditions
- Neonatal Thrombocytopenia, Intraventricular Hemorrhage, Platelet Transfusion
- Trial name
- MONET (NCT03110887)
- Volunteers
- 700 people
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Ticagrelor, Aspirin
Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets
The specific objective of this study is to investigate the potential for normal platelets to reverse the inhibition of platelet aggregation in patients treated with ticagrelor in combination with aspirin.
- Conditions
- Ticagrelor, Aspirin, Platelet Dysfunction Due to Drugs, Transfusion
- Trial name
- REVSTARTS (NCT03005704)
- Testing
- Antiplatelet treatment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Blood Platelets, Hematologic Diseases
Trial to Reduce Alloimmunization to Platelets (TRAP)
To determine the best, clinically useful procedure to prevent or minimize platelet alloimmunization as a cause of refractoriness to platelet transfusion in patients undergoing marrow ablative chemotherapy for acute myelogenous…
- Conditions
- Blood Platelets, Hematologic Diseases, Immunization, Leukemia, Myelocytic, Acute
- Trial name
- NCT00000589
- Testing
- platelet transfusion
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Blood Platelet Transfusion, Blood Clotting
Study to Reveal if Fibrinogen Treatment Effects Blood Clotting Better Than a Platelet Transfusion
Patients with need of platelet transfusion for any reason will participate in this study. Directly before the start of infusion and one hour after the end of platelet transfusion blood samples will be drawn and treated with…
- Trial name
- FiT2012 (NCT01955811)
- Testing
- Administration of platelet concentrate and taking blood samples
- Where
- 5 sites in Austria, Denmark
- Volunteers
- 130 people
- Sponsor
- Medical University Innsbruck
Poor Platelet Transfusion Outcome
Platelet Products Tested With the ThromboLUX® Platelet Quality Test
The planned minimal risk study is a blinded study on consecutive transfusable platelet products. The aim of the study is to evaluate the quality of platelet components sampled prior to transfusion.
- Trial name
- NCT02158416
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- LightIntegra Technology
Allogenic Transfusion of Platelets During Cardiac Surgery
High Yield Intraoperative, Autologous Platelet Apheresis
The overall aim is to reduce overall allogeneic transfusion requirements during cardiac surgery when compared to standard management.
- Trial name
- NCT01819246
- Testing
- Aphersis Treatment Arm, Control Arm
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University