Clinical trials: Platelets
Surgical Complication, Pain, Postoperative
Anti-inflammatory Effect of Platelet-Rıch Fıbrın
This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters.
- Conditions
- Surgical Complication, Pain, Postoperative, Edema Face
- Trial name
- NCT05336578
- Testing
- Platelet rich fibrin application
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nilay Er
Thrombelastography,Acute on Chronic Liver Failure, Platelet
A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of…
- Trial name
- NCT03281278
- Testing
- standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Idiopathic Thrombocytopenic Purpura
Comparative Study of Clinical Efficacy and Safety of GNR-069 and Nplate in Patients With ITP
It is a phase III multicenter randomized double-blinded comparative study of clinical efficacy and safety of GNR-069 and Nplate in patients with idiopathic thrombocytopenic purpura
- Trial name
- NCT05220878
- Testing
- GNR-069, Nplate
- Where
- 18 sites in Russia
- Volunteers
- 160 people
- Sponsor
- AO GENERIUM
Multi-drug Resistant Tuberculosis, Extensively Drug Resistant Tuberculosis
TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB
This study evaluated the safety and tolerability of low-dose linezolid (600 mg once daily) administered for 16 weeks as part of an optimized background regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB).
- Trial name
- LiMiT (NCT00664313)
- Testing
- Linezolid
- Where
- South Africa
- Volunteers
- 36 people
- Sponsor
- Centers for Disease Control and Prevention
Body Weight Changes
Cryolipolysis Induced Gluteal Fat Change
There was no difference in efficacy in removal of local fat on thigh by cryolipolysis through Zeltiq machine. Cryolipolysis was found to be safe for 12 week clinical trial.
- Trial name
- NCT04568187
- Testing
- zeltiq
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wonik Trade Company, Korea
Peridontal Disease
Efficacy of Injectable Platelet-rich Fibrin Versus Platelet-Rich Plasma As Adjunctive to Scaling and Root Planning in Non-surgical Periodontal Therapy of Periodontitis Patients
The study aims to evaluate the Efficacy of Injectable Platelet-rich Fibrin versus Platelet-Rich Plasma as adjunctive to scaling and root planning in non-surgical periodontal therapy of Periodontitis patients (Randomized…
- Trial name
- PRP-IPRF (NCT06685393)
- Testing
- Platelet rich plasma (PRP), INJECTABLE PLATELET RICH FIBRIN(I-PRF)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ELsabbahy Ahmed Mohamed Youssef
Congenital Heart Disease in Children
Amotosalen and Platelet Transfusion in Pediatric Heart Surgery
High level of security during blood transfusion has been achieved by donor selection and pathogen detection using serology or direct identification.
- Trial name
- TransPédia (NCT05128084)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Bone Loss, Alveolar
L-PRF in Alveolar Ridge Preservation
The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate.
- Trial name
- L-PRF (NCT03408418)
- Testing
- Platelet-rich fibrin
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Alopecia, Androgenetic
Comparing Platelet-Rich Plasma (PRP) Centrifugation Methods on Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia
This research is a preliminary, randomized, double blind clinical trial, which will examine the differences in PRP preparation methods, a single-spin centrifugation of 3000 rpm in 15 minutes compared to a double-spin…
- Trial name
- NCT05681897
- Testing
- Platelet-Rich Plasma Injections (PRP) on the Scalp
- Where
- 2 sites in Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Indonesia
Left Atrial Appendage Closure, WATCHMAN Device Implantation
The Evaluation of Thrombogenicity in Patients Undergoing WATCHMAN Left Atrial Appendage Closure Trial
This study will evaluate thrombogenicity in patients undergoing left atrial appendage closure using the WATCHMAN device. Parameters of thrombosis and platelet function, as well as other bio-markers, will be measure before…
- Trial name
- NCT03040622
- Testing
- WATCHMAN Left Atrial Appendage Closure
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Inova Health Care Services
Anterior Cruciate Ligament Injury
Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma
No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.
- Trial name
- NCT07269522
- Testing
- ACL reconstruction by hamstring graft with PRP, ACL reconstruction by hamstring graft
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Muhammad Aamir Latif
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Wound Healing
Effect of Leucocyte- and Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting
Autogenous palatal free gingival graft harvesting presents challenges for patients due to the increased risk of postoperative morbidity related to a second intraoral surgical wound that heals with secondary intention.
- Trial name
- NCT06777069
- Testing
- Leucocyte and platelet rich fibrin membrane application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istanbul Medipol University Hospital
Bleeding Disorders, Iron
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders
This is a prospective, single-arm, single-center observational study evaluating the impact of intravenous (IV) iron replacement in patients with inherited bleeding disorders and iron deficiency (ferritin <50ng/dL).
- Conditions
- Bleeding Disorders, Iron, Platelet, Bleeding
- Trial name
- IRON-BD (NCT07083583)
- Testing
- IV Iron (standard of care)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nicoletta C Machin
Healthy
Validation of an Assay to Measure Cyclooxygenase-1 Activity
The purpose of this study is to obtain a reference range for a newly developed assay of ex vivo platelet COX-1 activity in normal volunteers taking a routine clinical dose of aspirin.
- Trial name
- NCT00761891
- Testing
- Chewable aspirin
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dry Age-related Macular Degeneration
Atrophic Age-related Macular Degeneration Treated With Intravitreal Injections of Umbilical Cord Blood Platelet-rich Plasma
The objective of the study will be to evaluate the efficacy of intravitreal injections of Umbilical Cord Blood Platelet-rich Plasma (CB-PRP) in order to reduce or stabilize the atrophic progression in dry Age-related Macular…
- Trial name
- CORD-IV (NCT05706896)
- Testing
- Intravitreal injection of CB-PRP
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Otitis Media Chronic, Tympanic Membrane Perforation
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations.
- Trial name
- NCT04761562
- Testing
- Platelet- and extracellular vesicle-rich plasma, Control group
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Calcaneal Spur
Effect of Extracorporeal Shockwave Therapy, High Power-LASER & Platelet-rich Protein on Pain and Function in Patients With Calcaneal Spur A Randomized Comparative Study.
PURPOSE: To compare the effect of Extracorporeal shock wave therapy and high-power LASER therapy for the treatment of patients with calcaneal spur Background: Calcaneal spur is a common musculoskeletal disorder of the foot that…
- Trial name
- NCT06510673
- Testing
- Platelet rich plasma, High power LASER, Shockwave therapy
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Cairo University
Crowding of Anterior Maxillary Teeth
Repeated Injections of i-PRF for Decreasing Root Resorption After the Orthodontic Treatment.
Mandibular incisor crowding is a frequent issue that prompts many adults to seek orthodontic treatment. The treatment may enhance patients' quality of life, facilitate dental plaque control, and improve the quality of periodontal…
- Trial name
- NCT07352241
- Testing
- 4-time i-PRF injection group, Saline injection
- Where
- Syria
- Volunteers
- 36 people
- Sponsor
- Damascus University
Pyoderma Gangrenosum
Autologous Platelet-Rich Plasma Therapy in the Treatment of Pyoderma Gangrenosum
Pyoderma gangrenosum (PG) is a chronic inflammatory condition with severe painful ulcers. We hypothesize that Platelet-rich plasma(PRP) therapy derived from patient's own blood has a high concentration of endogenous growth…
- Trial name
- NCT05984654
- Testing
- Platelet rich plasma therapy
- Where
- United States
- Sponsor
- Ohio State University