Clinical trials: Pleura; Effusion
Malignant Pleural Effusion
Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion
The study is to investigate the anticancer effect and the related immunological mechanism of MTX-ATMPs in the treatment of malignant pleural effusion.
- Trial name
- NCT02657460
- Testing
- tumor derived microparticles, cisplatin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NSCLC
TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy
In this trial, anti-tumor efficacy of TAGRISSO in NSCLC patients in whom T790 mutations are detected by liquid biopsy.
- Trial name
- NCT03394118
- Testing
- Osimertinib
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Asan Medical Center
Stage IIIB or IV Non-Small Cell Lung Cancer
A Clinical Trial of Vorinostat (MK0683, SAHA) in Combination With FDA Approved Cancer Drugs in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)(0683-056)
This Phase III clinical trial which incorporates an initial Phase II component will determine the survival of advanced Non-small cell lung cancer patients when treated with MK0683 and paclitaxel plus carboplatin
- Trial name
- NCT00473889
- Testing
- vorinostat, Comparator: paclitaxel, Comparator: carboplatin
- Volunteers
- 253 people
- Sponsor
- Merck Sharp & Dohme LLC
Pneumonia, Pleural Effusion
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
The objective of this study is to assess whether there is a difference between a care protocol with the use of incentive spirometry (Voldyne ®) and another with the application of NIV (non invasive ventilation with single-level…
- Conditions
- Pneumonia, Pleural Effusion, Atelectasis
- Trial name
- NCT01416519
- Testing
- Continuous Positive Airway Pressure (CPAP) facial mask, Assisted deep inspiration technique
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Santa Casa de Votuporanga
Non-Small Cell Lung Cancer, Anemia
Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy
This is a study in patients with chemotherapy induced anemia receiving multi-cycle chemotherapy for the treatment of stage IV non-small cell lung cancer (NSCLC).
- Conditions
- Non-Small Cell Lung Cancer, Anemia, Cancer, Lung Cancer
- Trial name
- NCT00858364
- Testing
- Darbepoetin alfa
- Where
- 566 sites in United States, Argentina and 35 more
- Volunteers
- 2,549 people
- Sponsor
- Amgen
Pleural Effusion
Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Background: Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps.
- Trial name
- NCT04683419
- Testing
- Modified Thoracoscopic pleural Cryobiopsy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Pleural Effusion
Using Pleural Effusions to Diagnose Cancer
Pleural effusions (PE) are common conditions that signal either infection or cancer. The investigators aim to develop, validate, and prospectively assess the MAPED score, a clinical score that predicts malignancy at admission.
- Trial name
- MAPED (NCT03319472)
- Where
- Greece
- Volunteers
- 439 people
- Sponsor
- University of Patras
Carcinoma, Non-Small-Cell Lung
The 'MADe IT' Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer
The standard treatment for non-small cell lung cancer, stage IV or IIIB malignant pleural effusion is chemotherapy. The decision to use a regimen is currently determined by toxicity or by physician's preference.
- Trial name
- NCT00215930
- Testing
- Vinorelbine, Docetaxel, Gemcitabine
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Metastatic Cancer
Talc in Treating Patients With Malignant Pleural Effusion
RATIONALE: Talc may relieve malignant pleural effusion. It is not yet known whether wet talc is more effective than dry talc in treating patients with malignant pleural effusion.
- Trial name
- NCT00002622
- Testing
- talc
- Where
- 241 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Pleural Effusion, Malignant
IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
The purpose of this study was to evaluate the efficacy of IFN- Y combined with T cells in the treatment of refractory malignant pleural effusion and acties, using a multicenter, single-arm, open design.
- Trial name
- NCT05268172
- Testing
- IFN-γ and CIK cells, Tcm cells or CAR T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Lung Cancer, Breast Cancer
Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion
This is a prospective, open-label , multicenter randomized controlled trial, with 248 cases in 50 centers planned for a period of 2 years.
- Conditions
- Lung Cancer, Breast Cancer, Malignant Pleural Effusion
- Trial name
- NCT04131231
- Testing
- microparticles packaging methotrexate (MPs-MTX), recombinant human interleukin-2(rhIL-2)
- Volunteers
- 248 people
- Sponsor
- Peking Union Medical College
Pleural Effusion, Tuberculosis, Pleural
A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From Malignant Pleural Effusion
Primary Endpoint To assess the prevalence and diagnostic performance of pre-determined echographic features in predicting the diagnosis of TBE from MPE.
- Conditions
- Pleural Effusion, Tuberculosis, Pleural, Malignant Pleural Effusion
- Trial name
- TUS-TBE (NCT05935696)
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Sarawak General Hospital
Malignant Pleural Effusion
Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion
Comparision between pleurodesis by pleural abrasion using medical thoracoscopy and bleomycin instillation via indwelling pleural catheter.
- Trial name
- NCT06691009
- Testing
- Group 1 (mechanical pleurodesis), Group 2 chemical pleurodesis by bleomycin)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pleural Effusion, Pleural Diseases
Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique
The purpose of this study is to determine feasibility of pleural biopsies with the cryoprobe during semirigid thoracoscopy. The secondary aim is to evaluate safety with focus on bleeding intensity.
- Trial name
- NCT01472172
- Testing
- Cryobiopsy (Autoclavable cryoprobe 20416-032)
- Where
- Slovenia
- Volunteers
- 15 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Lung Cancer, Non-Small Cell
A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC
This is a phase II study. All patients are stage IV non-squamas non-small cell lung cancer(NSCLC) with malignant pleura effusion, Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Trial name
- NCT06769295
- Testing
- AK112
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sichuan University
Pleural Effusion
A Feasibility and Safety Study of the Use of a Dedicated Ballooned Intercostal Drain
Drainage of air and fluid from the chest cavity using plastic tubes (chest drains) is an essential tool in Chest Medicine. A common complication of drain insertion is accidental removal of the drain, usually as a result of…
- Trial name
- NCT01869504
- Testing
- Balloon-tipped intercostal drain
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sherwood Forest Hospitals NHS Foundation Trust
Pleural Effusion
Comparing Active Versus Passive Aspiration in Therapeutic Thoracentesis: Efficacy, Procedure Time, and Patient Safety
This single-blind randomized controlled trial (RCT) aims to compare the efficacy and safety of active manual aspiration versus passive gravity drainage during therapeutic thoracentesis for large symptomatic pleural effusions.
- Trial name
- Thoracentesis (NCT07184736)
- Testing
- Active Manual Syringe Aspiration, Passive Gravity Drainage
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Solid Tumor, Pleural Effusion
Collection of Pleural Effusion Fluid
At the Laboratory for Molecular and Cellular Therapy (LMCT) of the Vrije Universiteit Brussel, Belgium, we study resistance mechanisms that hamper effective immunotherapy for solid cancer patients.
- Conditions
- Solid Tumor, Pleural Effusion, Metastasis
- Trial name
- NCT05539183
- Testing
- Blood withdrawal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Pleural Effusion, Malignant Pleural Effusions
Quantitative C-Reactive Protein for Differentiating Tuberculous and Malignant Pleural Effusion: a Cross-Sectional Study
The goal of this observational study is to evaluate the role of pleural fluid Quantitative C-Reactive Protein (Q-CRP) levels in distinguishing between tuberculous and malignant pleural effusion in adult patients with lymphocytic…
- Conditions
- Pleural Effusion, Malignant Pleural Effusions, Tuberculous Pleural Effusion
- Trial name
- NCT06729931
- Testing
- Pleural Fluid Quantitative C-Reactive Protein (Q-CRP) Measurement
- Where
- Nepal
- Volunteers
- 81 people
- Sponsor
- Maharajgunj Medical Campus
Pleural Effusion, Malignant
EDIT Management Feasibility Trial
Malignant Pleural Effusion (MPE) is a collection of fluid inside the chest caused by cancer. It is a common medical problem and often causes severe breathlessness.
- Trial name
- Pre-EDIT (NCT03319186)
- Testing
- EDIT Management, Chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde