Clinical trials: Pleura; Effusion
Pleural Effusion
Thoracic Ultrasound in the Treatment of Pleural Effusion
The main objective of the study is to assess the cost-effectiveness ratio of two management strategies of pleurisy in adults : a strategy by systematic thoracic ultrasound versus a strategy without thoracic ultrasound.
- Trial name
- ECHOPLEV (NCT02505763)
- Testing
- Strategy with thoracic ultrasound
- Where
- France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Toulouse
Pleural Effusion, Pleural Diseases
Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy
The aim of this study is to compare the rigid thoracoscopy with CT-guided pleural needle biopsy by the diagnostic efficacy and safety in patients with pleural effusion.
- Trial name
- NCT00720954
- Testing
- Ct-guided pleural needle biopsy, Thoracoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Eskisehir Osmangazi University
Tuberculous Pleural Effusion
Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection
This retrospective cohort study evaluates the efficacy and safety of intrapleural fibrinolytic therapy (tPA/DNase) in patients with tuberculous pleural effusion compared with non-tuberculous pleural infection at Hospital Canselor…
- Trial name
- FIB-TB (NCT07823075)
- Testing
- Intrapleural Fibrinolytic Therapy (IPFT)
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- National University of Malaysia
Pleural Effusion, Malignant, Lung Neoplasms
Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis
Prospective study of the effect of Talc Pleurodesis vs. Indwelling Pleural catheter in treatment of patients with malignant pleural effusion
- Trial name
- NCT02825095
- Testing
- Talc Pleurodesis, Indwelling Pleural Catheter, chest ultrasound
- Volunteers
- 120 people
- Sponsor
- Rambam Health Care Campus
Non-expandable Lung, Trapped Lung
ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG
This is a randomised controlled trial evaluating whether controlled air introduction into pleural space (air entrainment) during pleural effusion drainage reduces pain, improves patient satisfaction, and facilitates more…
- Conditions
- Non-expandable Lung, Trapped Lung, Pleural Effusion, Malignant Pleural Effusions (Mpe)
- Trial name
- ARMSTRONG (NCT06959719)
- Testing
- Air Entrainment - intentional introduction of the atmospheric air into the pleural space.
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pleural Effusion, Malignant, Pleural Effusion
A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid where initial diagnostic tests have been inconclusive are the focus of this trial.
- Conditions
- Pleural Effusion, Malignant, Pleural Effusion, Pleura; Exudate
- Trial name
- NCT04233359
- Testing
- Local anesthetic thoracoscopy, US-guided pleural biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 4 people
- Sponsor
- Naestved Hospital
Pleural Effusions, Respiratory Failure
Drainage Of Pleural Effusions in the Intensive Care Unit (DOPE-ICU) - Feasibility Trial
This trial evaluates the feasibility of ultrasound-guided pleural drainage versus no drainage in adult ICU patients with pleural effusions (fluid buildup around the lungs) and respiratory failure.
- Trial name
- NCT06709456
- Testing
- Ultrasonography-guided pleural drainage
- Where
- 6 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- Olav Schjørring
Pleural Effusion, Blood Pressure
PDMS Outcome After Intensive Care, Organdysfunction and Monitoring
The objective of the explorative registry study is to investigate outcome parameters in the routine treatment of patients who are monitored after heart surgery for either short or long-term treatment in the intensive care unit…
- Trial name
- PONTOS (NCT03379688)
- Where
- Germany
- Volunteers
- 6,909 people
- Sponsor
- Charite University, Berlin, Germany
Pleural Effusion
Sustained Effects of Thoracocentesis in Mechanically Ventilated Patients
Collections of fluid around the lung (pleural effusions) are common in patients on mechanical ventilation. Long stays on mechanical ventilation can lead to serious complications such as pneumonia and are associated with…
- Trial name
- NCT00915161
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Oxford University Hospitals NHS Trust
Esophageal Cancer, Lung Cancer
Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of decitabine in treating patients who have unresectable…
- Conditions
- Esophageal Cancer, Lung Cancer, Malignant Mesothelioma, Metastatic Cancer
- Trial name
- NCT00019825
- Testing
- decitabine
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Pleural Effusion
Prospective Evaluation of Patients With Pleural Effusion
Having a pleural effusion is a common reason for being hospitalized, as it usually requires in-patient care for invasive diagnostic and therapeutic procedures.
- Trial name
- NCT05759117
- Testing
- thoracentesis
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Malignant Pleural Effusions, Recurrent Pleural Effusions
A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis
Pleurodesis is a technique used to fuse the two layers of the lining over the lung. This is done to get rid of collections of fluid or air in this space.
- Conditions
- Malignant Pleural Effusions, Recurrent Pleural Effusions, Primary Spontaneous Pneumothorax, Secondary Spontaneous Pneumothorax
- Trial name
- NCT00430664
- Testing
- Pleurodesis with either talc or iodopovidone
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Malignant Pleural Effusion
Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion
Comparision between pleurodesis by pleural abrasion using medical thoracoscopy and bleomycin instillation via indwelling pleural catheter.
- Trial name
- NCT06691009
- Testing
- Group 1 (mechanical pleurodesis), Group 2 chemical pleurodesis by bleomycin)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pleural Effusion, Pleural Effusion, Malignant
Multiple Biomarkers in Undiagnosed Pleural Effusion
The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions.
- Trial name
- NCT00316134
- Testing
- Procedure/Surgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fujirebio Diagnostics, Inc.
Non-Small Cell Lung Cancer, Anemia
Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy
This is a study in patients with chemotherapy induced anemia receiving multi-cycle chemotherapy for the treatment of stage IV non-small cell lung cancer (NSCLC).
- Conditions
- Non-Small Cell Lung Cancer, Anemia, Cancer, Lung Cancer
- Trial name
- NCT00858364
- Testing
- Darbepoetin alfa
- Where
- 566 sites in United States, Argentina and 35 more
- Volunteers
- 2,549 people
- Sponsor
- Amgen
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Malignant Pleural Effusion, Non-small Cell Lung Cancer
Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)…
- Trial name
- NCT04806412
- Testing
- meassurement of PD-L1, ALK, EGFR
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Naestved Hospital
Malignant Pleural Effusion
Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients
This study will take place in Ottawa, Ontario, and will include 100 patients who are receiving tunnelled pleural catheters to treat their symptoms of MPE.
- Trial name
- NCT03403855
- Testing
- Rocket® IPC- Long External Length, Rocket® IPC- Short External Length
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Malignant Pleural Effusion
Cytological Examination of Malignant Pleural Effusion in Breast Cancer
Malignant pleural effusion (MPE) is characterized by the presence of malignant cells. It can occur in 15% of patients with cancer and is a common manifestation in patients with metastatic disease.
- Trial name
- NCT06657638
- Testing
- Thoracentesis
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University Hospital
Lung Cancer
Immunomagnetic Detection of Cancer Cells in Pleural Effusion in Lung Cancer Patients as Additional Staging and Prognostic Tool
Pleural effusion in lung cancer patients is one of the symptoms of metastatic disease that is inoperable and cannot be treated. Identification of cancer cells in the pleural effusion of lung cancer patients is a cytological test…
- Trial name
- NCT02172027
- Testing
- Immunomagnetic Detection
- Sponsor
- Meir Medical Center