Clinical trials: Pleural Diseases
Mesothelioma, Malignant, Mesothelioma, Malignant Pleural
First Line Sintilimab Combined With Anlotinib and Platinum Doublet Chemotherapy in Malignant Pleural Mesothelioma
This study is a single-arm, open-lable, single-center phase II clinical trial for patients with advanced or metastatic pleural mesothelioma.
- Conditions
- Mesothelioma, Malignant, Mesothelioma, Malignant Pleural, Mesothelioma Malignant Advanced
- Trial name
- NCT05188859
- Testing
- Sintilimab+Anlotinib+Pemetrexed+Cisplatin
- Where
- 2 sites in China
- Volunteers
- 29 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pneumothorax and Air Leak, Pneumothorax
Urine Bag Usage Versus Chest Drain Clamping After Lung Resection Surgeries
Investigators will compare two different approaches of postoperative drainage after the standard water-seal drain has been used efficiently; one is by using urine bag and check it get blown by the leaked air, two is by using…
- Conditions
- Pneumothorax and Air Leak, Pneumothorax, Pleura Injury, Pleural Effusion
- Trial name
- NCT05230420
- Testing
- Clamping, Urine bag
- Where
- 4 sites in Egypt, Italy and 1 more
- Volunteers
- 160 people
- Sponsor
- Al-Quds University
Lung Cancer, Lung Metastases
Oxford Pleural Embolisation Trial
Thermal ablation is an established treatment for lung cancer. It involves insertion of a applicator under image guidance into a lung tumour and destroying it with radiofrequency, microwave or cryotherapy.
- Trial name
- OxPET (NCT06651658)
- Testing
- Pleural embolisation
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- Oxford University Hospitals NHS Trust
Auscultation, Breathing Sound
Enhancing Respiratory Auscultation Skills Among Medical Students: Digital Stethoscopes in Medical Education
Objectives: This study aims to assess the effectiveness of a novel digital stethoscope curriculum integrated into respiratory auscultation training for medical students.
- Conditions
- Auscultation, Breathing Sound, Asthma, Pneumonia
- Trial name
- NCT06359158
- Testing
- Digital stethoscope use
- Where
- Taiwan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Lung Cancer, Non-small Cell Lung Cancer (NSCLC)
Phase I Trial of Afatinib (BIBW 2992) and Dasatinib in Non-small Cell Lung Cancer (NSCLC)
The purpose of this study is to: Find out if the study drugs Afatinib and Dasatinib can be safely given together to patients with lung cancer Learn how these two drugs work in cancer cells when they are combined Learn more about…
- Trial name
- NCT01999985
- Testing
- Dasatinib - 1A, Afatinib - 1A, Dasatinib - 1B
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pneumothorax
Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort
Transthoracic lung biopsy (TLB) provides a histological diagnosis of nodule or lung mass. Pneumothorax is the main complication of TLB with an average of 20%.
- Trial name
- SPOT (NCT03488043)
- Testing
- Needle lung biopsy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pleural Metastases, Breast Cancer
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
Cancers that have spread to the inner lining of the chest are classified as Stage IV and bear a poor prognosis. Surgery is rarely an option, with palliative chemotherapy and/or radiation therapy the only treatment options.
- Conditions
- Pleural Metastases, Breast Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT01163552
- Testing
- Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Lung Cancer
Study of Weekly Paclitaxel, Carboplatin and Irinotecan to Treat Lung Cancer
Evaluate the efficacy and toxicity of the weekly combination chemotherapy of Paclitaxel, Carboplatin and Irinotecan in Stage IIIb and IV NSCLC with malignant pleural effusion
- Trial name
- NCT00465907
- Testing
- Paclitaxel, Carboplatin and Irinotecan
- Where
- Singapore
- Volunteers
- 7 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple
AI Assisted Detection of Chest X-Rays
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple, Pulmonary Consolidation, Pneumothorax
- Trial name
- AID-CXR (NCT06075836)
- Testing
- Cases reading, Ground truthing
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Pleural Effusion Due to Another Disorder (Disorder)
Natural History of Nonspecific Pleuritis Diagnosed After Video-assisted-thoracoscopic-surgery
The investigators want to determine the incidence of malignant disease, type of malignant disease and overall survival in patients diagnosed with NSP after VATS.
- Trial name
- NCT03270228
- Testing
- Nonspecific pleuritis after VATS thoracoscopy
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- Naestved Hospital
Spinal Deformity, Hemothorax Postoperative
Hemothorax Caused by Posterior Correction Surgery for Spinal Deformity
Owing to the development of instruments and surgical techniques, the number of spinal deformity correction surgeries has increased significantly.
- Trial name
- NCT05579834
- Testing
- posterior correction surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Gazi University
Pleural Effusion, Dyspnea
Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis
Recurrent fluid surrounding the lungs is associated with poor quality of life, the main symptom being dyspnea. These patients are in need of recurrent removal of the fluid using drainage.
- Conditions
- Pleural Effusion, Dyspnea, Patient Reported Outcomes, Diaphragm Movement
- Trial name
- NCT04236934
- Testing
- Assesment of diaphragm shape and diaphragm movement (by M-mode and the AREA-method) by ultrasound before and after thoracentesis
- Where
- 2 sites in Denmark
- Volunteers
- 107 people
- Sponsor
- Naestved Hospital
Malignant Pleural Mesothelioma
Effect of Expression of CD74 and VEGF on Outcome of Treatment in Patients With Malignant Pleural Mesothelioma
This is a prospective study evaluating the effect of expression of CD74 and VEGF on outcome of treatment in patients with malignant pleural mesothelioma receiving Pemetrexed/Platinum protocol.
- Trial name
- NCT02761863
- Testing
- CD 74, VEGF detection
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Malignant Pleural Mesothelioma, Unresectable Malignant Neoplasm
Observational Study in Patients With Previously Unresectable Malignant Pleural Mesothelioma Treated With Nivolumab and Ipilimumab (MESO-IMMUNE)
Meso-Immune is a retrospective study to assess the efficacy and safety of the combination of Nivolumab and Ipilimumab used in first-line treatment of adult patients with unresectable Malignant Pleural Mesothelioma (MPM).
- Trial name
- MESO-IMMUNE (NCT05308966)
- Testing
- Data collection
- Where
- 63 sites in France
- Volunteers
- 204 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Lung Nodules, Pneumothorax Iatrogenic Postprocedural
Pneumothorax Safety of Pleural-Depth-Trimmed Hookwires for Lung Nodule Localization
The goal of this observational study is to learn about the pneumothorax risk associated with the Pleural-Depth-Trimmed Hookwire (PDTH) technique in patients undergoing Preoperative CT-Guided Lung Nodule Localization (POCTGL).
- Conditions
- Lung Nodules, Pneumothorax Iatrogenic Postprocedural, Propensity Score Matching
- Trial name
- NCT07300072
- Testing
- Preoperative CT-Guided Lung Nodule Localization with Pleural-Depth-Trimmed Hookwire (PDTH) Technique, Preoperative CTGuided Lung Nodule Localization with Patent Blue Vital Dye (PBVD) Localization Technique
- Where
- Taiwan
- Volunteers
- 1,072 people
- Sponsor
- Chung Shan Medical University
Chylothorax, Esophageal Cancer
FLOTOR Pilot Study
This is a non-randomised study assessing the technique of using indocyanine green as a fluorescent dye to highlight the thoracic duct during oesophectomy.
- Conditions
- Chylothorax, Esophageal Cancer, Thoracic Duct Intra-Operative Injury
- Trial name
- FLOTOR (NCT03292757)
- Testing
- Indocyanine Green
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Colorectal Cancer Not MSI-H or MMR-deficient, GIST
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors
Assessment of the efficacy and safety of Regorafenib and Avelumab in patients with advanced or metastatic solid tumors (ten cohorts), once the Recommanded Phase II Dose (RP2D) has been determined (phase I trial).
- Conditions
- Colorectal Cancer Not MSI-H or MMR-deficient, GIST, Oesophageal or Gastric Carcinoma, Biliary Tract Cancer
- Trial name
- REGOMUNE (NCT03475953)
- Testing
- Phase 1 : Regorafenib, Phase 1 : Avelumab, Phase 2 : Regorafenib
- Where
- 7 sites in France
- Volunteers
- 747 people
- Sponsor
- Institut Bergonié
Pleural Diseases, Pleural Neoplasms
Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis
Recently, probe based confocal laser endomicroscopy showed to be able to distinguish malignant from benign pleura during medical thoracoscopy. However The clinical usefulness of this new tool remains to be determined.
- Trial name
- NCT04731129
- Testing
- Probe based confocal laser endomicroscopy of the pleura
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- University of Liege
Kidney Neoplasms, Kidney Cancer
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer
This study will investigate the genetic cause of Birt Hogg-Dube (BHD) syndrome and the relationship of this disorder to kidney cancer.
- Conditions
- Kidney Neoplasms, Kidney Cancer, Pneumothorax, FLCN Protein, Human
- Trial name
- NCT00033137
- Where
- United States
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Malignant Mesothelioma
Gemcitabine and Epirubicin in Treating Patients With Malignant Mesothelioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00017186
- Testing
- epirubicin hydrochloride, gemcitabine hydrochloride
- Where
- 24 sites in United States
- Volunteers
- 69 people
- Sponsor
- Alliance for Clinical Trials in Oncology