Clinical trials: Pleural Infection
Hemothorax, Hemopneumothorax; Traumatic
Prospective Evaluation of 14F Thal Tube vs 28 French Chest Tube for Hemothorax and Use of Maximum Barrier Precautions
Traumatic hemothorax and hemopneumothorax are common diagnoses which are typically treated by placement of a chest tube. 28-32 Fr chest tubes have previously been shown equivalent to 36-40 Fr chest tubes for the non-emergent…
- Conditions
- Hemothorax, Hemopneumothorax; Traumatic, Empyema, Chest Tube Size
- Trial name
- NCT03167723
- Testing
- Chest tube placement
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Wake Forest University Health Sciences
Pleuritis
Predictive Factors and Outcome in Medical Thoracoscopy
Retrospective survey for factors predicting the outcome of medical thoracoscopy
- Trial name
- NCT02288065
- Testing
- sterile talc pleurodesis
- Where
- Belgium
- Volunteers
- 155 people
- Sponsor
- KU Leuven
Pleural Infection, Pleural Diseases
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator…
- Trial name
- NCT02973139
- Testing
- Medical Thoracoscopy, Fibrinolytic Group
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Beth Israel Deaconess Medical Center
Mechanical Ventilation, SARS-CoV-2
Transpulmonary Driving Pressure in ARDS COVID19 Patients
A majority (65-85%) of critically ill patients admitted in intensive care units with a confirmed diagnostic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) developed an acute respiratory distress syndrome (ARDS)…
- Conditions
- Mechanical Ventilation, SARS-CoV-2, COVID-19
- Trial name
- TRANSPULMONARY (NCT04381286)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Tuberculosis, Post-Tuberculous Pleural Fibrosis
Endurance Training in Patients With Post-TB Lung Disease
To determine the effects of endurance training on functional capacity and QOL(Quality of life) in patients with post-TB (tuberculosis) lung disease. Post-tuberculosis lung disease is a major health concern nowadays.
- Conditions
- Tuberculosis, Post-Tuberculous Pleural Fibrosis, Post-Tuberculous Bronchiectasis
- Trial name
- NCT06047795
- Testing
- Experimental, Control
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Parapneumonic Pleural Effusion, Empyema
Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
STUDY JUSTIFICATION 1. Scientific evidence of the usefulness of corticosteroid use for infectious diseases: Corticosteroids along with antibiotic use improve survival in some infectious processes provide long term benefits and…
- Trial name
- CORTEEC (NCT01261546)
- Testing
- Dexamethasone
- Where
- 8 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Infanta Sofia
Pneumothorax, Hydrothorax
KatGuide Method Versus Conventional Method at Insertion of Chest Tube
The purpose of this study is to investigate whether if KatGuide (a new developed medical device) improves the placing of a large bore chest tube in the pleural cavity compared to the conventional method.
- Conditions
- Pneumothorax, Hydrothorax, Hemothorax, Empyema
- Trial name
- KatGuide (NCT01522885)
- Testing
- KatGuide versus conventional method (forceps), Chest tube insertion
- Where
- 4 sites in Denmark
- Volunteers
- 109 people
- Sponsor
- Niels Katballe
Pleural Effusion, Heart Failure
Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)
To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).
- Conditions
- Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload
- Trial name
- NCT05797649
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Pleural Infection, Pleural Infection Bacterial
The Microbiology of Pleural Infection
Pleural Infection (PI) is a common, severe and complicated disease with considerable morbidity and mortality. (1,2) The knowledge of pleural infection microbiology remains incomplete.
- Trial name
- TORPIDS (NCT04569110)
- Testing
- Not applicable. Observational study. Retrospective analysis of samples.
- Where
- United Kingdom
- Volunteers
- 251 people
- Sponsor
- University of Oxford
Empyema, Pleural
Retrospective Review on Patients With Culture Negative Empyema
Empyema is associated with a wide range of complication and mortality. It is defined by either a positive pleural fluid culture or grossly pus appearance.
- Trial name
- NCT04477980
- Testing
- Disease outcome (mortality)
- Where
- Hong Kong
- Volunteers
- 153 people
- Sponsor
- Chinese University of Hong Kong
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pneumonia, Bronchopneumonia
Duration of Antibiotic Therapy in Community - Acquired Pneumonia
The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject's clinical response compared to a local standard approach in patients coming from the…
- Conditions
- Pneumonia, Bronchopneumonia, Pleuropneumonia, Pneumonia, Bacterial
- Trial name
- DURATION (NCT01492387)
- Testing
- Discontinuation of antibiotic therapy
- Where
- 15 sites in Italy
- Volunteers
- 892 people
- Sponsor
- University of Milan
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 28 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Respiratory Failure, Atelectasis
Low Tidal MEChanical Ventilation Against NO Ventilation During Cardiopulmonary Bypass Heart Surgery
BACKGROUND. Postoperative pulmonary complications are a leading cause of morbidity and mortality after cardiac surgery. To this date, there are no recommendations regarding mechanical ventilation associated with cardiopulmonary…
- Conditions
- Respiratory Failure, Atelectasis, Pneumonia, Pneumothorax
- Trial name
- MECANO (NCT03098524)
- Testing
- Low tidal volume ventilation (LTV arm), No ventilation (noV arm), Lung recruitment manoeuver
- Where
- France
- Volunteers
- 1,502 people
- Sponsor
- CMC Ambroise Paré
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pleural Effusion, Pleurisy
Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy
This is a prospective study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections in patients undergoing medical thoracoscopy.
- Conditions
- Pleural Effusion, Pleurisy, Empyema
- Trial name
- APT (NCT02446782)
- Testing
- Cefazolin, saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Community-Acquired Infections
Management of Parapneumonic Pleurisy Guided by an Early Pleural Ultrasound
Parapneumonic pleurisies are a frequent complication of pneumopathies, but therapeutic management is poorly codified. Only the indication of thoracic drainage has benefited from expert recommendations.
- Trial name
- ECHOPP (NCT04348734)
- Testing
- pleural ultrasound
- Where
- 4 sites in France
- Volunteers
- 115 people
- Sponsor
- Central Hospital Saint Quentin
Pleural Neoplasms, Aspiration, Respiratory
Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
This study aims to evaluate the efficacy of single dose analgesia in combination with local anesthesia to control pain during Trans Ultrasound guided procedures.
- Conditions
- Pleural Neoplasms, Aspiration, Respiratory, Pleural Effusion, Lung Neoplasms
- Trial name
- NCT05121233
- Testing
- Diclofenac
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tuberculous Pleurisy
Corticosteroids in the Treatment of Tuberculous Pleurisy
Tuberculous pleurisy is associated with inflammation and fibrosis. Adjunctive corticosteroids are used for tuberculous pleurisy because their anti-inflammatory effect is thought to minimise pleural reactivity and thereby reduce…
- Trial name
- NCT00338793
- Testing
- prednisolone
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Guangxi Medical University