Clinical trials: Pleurodesis
Primary Spontaneous Pneumothorax
Autologous Blood Patch for Primary Spontaneous Pneumothorax
The purpose of this study is to show that treatment with prophylactic autologous blood patch (ABP) after management of primary spontaneous pneumothorax (PSP) is feasible, reduces the incidence of prolonged air leaks, and reduces…
- Trial name
- NCT06088901
- Testing
- Autologous Blood Patch
- Where
- United States
- Sponsor
- Rush University Medical Center
Malignant Pleural Effusions (Mpe)- Pleurodesis, Pleurodesis
Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion
Comparing Two Methods to Treat Fluid Build-up in Chest for Cancer Patients:Talc Powder Surgery versus Chest Tube Medicine.
- Trial name
- NCT06744946
- Testing
- thoracoscope
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohamed Sabry
Pleural Effusion, Malignant
Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Management
This is a multicentre randomised controlled trial evaluating global health related quality of life outcomes in patients with malignant pleural effusions.
- Trial name
- OPTIMUM (NCT02517749)
- Testing
- Chest Drain Insertion and Talc Pleurodesis, Indwelling Pleural Catheter Insertion and Talc Pleurodesis
- Where
- United Kingdom
- Volunteers
- 142 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary
Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis
Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall.
- Conditions
- Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant, Pleurodesis
- Trial name
- NCT07167992
- Testing
- Pleurodesis
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Primary and Secondary Spontaneous Pneumothorax
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?
Investigators aim to assess if NSAIDs affect the quality of pleurodesis resulting from mechanical pleurodesis (open surgery or VATS) regarding : Primary outcome: Recurrence of pneumothorax in 6 monthes.
- Trial name
- NCT06467318
- Testing
- Paracetamol, NSAID, Paracetamol
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pleural Neoplasm
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE).
- Trial name
- NCT03465774
- Testing
- Doxycycline, Indwelling Catheter, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusion
Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion
The primary purpose of this study is to determinate the degree of chest pain on patients with malignant pleural effusion submitted to pleurodesis with silver nitrate in three different dosages and concentrations ( 30ml 0.5% …
- Trial name
- NCT01125124
- Testing
- Silver Nitrate
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Malignant Pleural Effusion
Tunneled Pleural Catheter in Partially Entrapped Lung
An open randomized, prospective, single center; parallel group trial to compare efficiency and safety of PleurX-Pleural Catheter versus standard surgical treatment in patients with malignant pleural effusion and partial…
- Trial name
- NCT00637676
- Testing
- VATS, Talc-Pleurodesis, tunneled pleural drainage, VATS, Talc-pleurodesis
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Pneumothorax
Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax
Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis.
- Trial name
- NCT00270751
- Testing
- 1 apical pleurectomy, 2 pleural abrasion + minocycline pleurodesis
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Non-steroidal Anti-inflammatory Drugs, Pleurodesis
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use.
- Conditions
- Non-steroidal Anti-inflammatory Drugs, Pleurodesis, Pneumothorax, Pain Management
- Trial name
- KETOTHORAX (NCT06731647)
- Testing
- pleurodesis procedures, KETOPROFEN(RP19583)
- Where
- France
- Volunteers
- 358 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pleural Effusion, Malignant
Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis
The primary goal of this study is to compare well-defined pleural effusion management success outcomes in patients with malignant or paramalignant pleural effusions who were treated with Indwelling pleural catheter insertion…
- Trial name
- NCT03781908
- Testing
- Silver Nitrate, Indwelling Pleural Catheter
- Volunteers
- 50 people
- Sponsor
- Assiut University
Malignant Pleural Effusion
Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination
Title of study: Comparison of the Effectiveness of Povidone-Iodine alone to Povidone-Iodine--Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural Effusion.
- Trial name
- NCT04039126
- Testing
- CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION, CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE
- Where
- Nigeria
- Volunteers
- 62 people
- Sponsor
- University College Hospital, Ibadan
Pleural Effusion, Pleurodesis
Betadine Pleurodesis Via Tunneled Pleural Catheters
The purpose of this study is to determine whether betadine (povidone-iodine) instillation during routine indwelling Tunneled Pleural Catheter (TPC) placement is efficacious in promoting pleurodesis and thus reducing the time to…
- Conditions
- Pleural Effusion, Pleurodesis, Malignant Pleural Effusion, Pleural Effusion Due to Congestive Heart Failure
- Trial name
- NCT02975921
- Testing
- Povidone-Iodine
- Sponsor
- Yale University
Pleural Effusion, Malignant
Pleurodesis in Small-bore Chest Tube
Malignant pleural effusion (MPE) imposes a high burden on the healthcare system in the Asian Pacific region, as lung and breast cancer are the commonest cancers associated with malignant pleural effusion, as the two commonest…
- Trial name
- NCT07208409
- Testing
- 14 Fr chest tube, 12 Fr chest tube, 8 Fr chest tube
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Pleural Effusion, Malignant, Non-small Cell Carcinoma
Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer
In this trial, the effect of intrapleural docetaxel administration using medical pleuroscopywill be evaluated in Lung Cancer patient with malignant effusion.
- Trial name
- NCT03394105
- Testing
- intrapleural docetaxel administration
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Asan Medical Center
Safety of Intervention, Efficacy of Intervention
Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.
Aim of this study is to compare two methods of pleurodesis for refractory malignant pleural effusions, in terms of safety and efficacy.
- Conditions
- Safety of Intervention, Efficacy of Intervention, Cost Effectiveness
- Trial name
- NCT01409551
- Testing
- VATS hyperthermic chemoperfusion, Bedside talc slurry pleurodesis
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Theagenio Cancer Hospital
Pleural Effusion
Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis
Prospective Randomized Double-Blind Controlled Trial of Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis versus Standard of care Talc therapy in patients with recurrent pleural effusion.
- Trial name
- NCT04806373
- Testing
- Cathflo Activase, Talc Slurry Pleurodesis
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Memorial Healthcare System
Bilateral Pleural Effusion, Pleurodesis
Synchronous Bilateral Talc Pleurodesis
Investigate feasibility of synchronous bilateral talc pleurodesis for malignant bilateral pleural effusions
- Trial name
- NCT07810049
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- European Institute of Oncology
Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis
Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion
This study is designed as a prospective, multi-center investigation to explore the efficacy and safety of furmonertinib combined with upfront thoracic radiotherapy with or without metastatic lesion radiotherapy in subjects with…
- Trial name
- NCT07482605
- Testing
- Furmonertinib, Thoracic Radiotherapy (TRT)
- Volunteers
- 63 people
- Sponsor
- Jiangmen Central Hospital
Non Small Cell Lung Cancer
Dry Pleurodesis With Talcum and Afatinib is Used to Treat Patients With Non-Small Cell Lung Carcinoma
In non-small cell lung cancer and metastases in the pleural cavity, pathological effusion is formed. Currently, the most common and effective method of obliteration of the pleural cavity is pleurodesis with talcum powder.
- Trial name
- DPTA (NCT03827070)
- Testing
- Afatinib, Talcum powder
- Where
- Georgia
- Volunteers
- 12 people
- Sponsor
- Center Trials & Treatment Europe