Clinical trials: Pneumococcal Carriage
HIV Infection, Pneumococcal Infections
Serological Response to Antipneumococcal Vaccination and Impact on Streptococcus Pneumoniae Nasal Carriage in HIV Adults
S. pneumoniae is frequently isolated from nasal swabs of healthy subjects, but it can also cause severe diseases (pneumonia, bacteraemia, meningitis and sepsis).HIV-infected subjects are more sensitive to invasive diseases and…
- Trial name
- PCV13HIV2011 (NCT02123433)
- Testing
- pneumococcal conjugate 13 valent vaccine
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Siena
Streptococcal Pneumonia, Nasopharyngeal Diseases
PCV7 in the Prevention of Nasopharyngeal Carriage of Vaccine Serotype (VT) Streptococcus Pneumoniae
A parallel-group, randomized, open-label study will be performed in subjects receiving PCV7 and subjects receiving controlled vaccine Hib vaccine, to claim the efficacy of PCV7 in the prevention of NP carriage of vaccine-serotype…
- Conditions
- Streptococcal Pneumonia, Nasopharyngeal Diseases, Vaccination Adverse Event
- Trial name
- NCT02133469
- Testing
- PCV7 (Pneumococcal 7-Valent Conjugate Vaccine), Hib Vaccine
- Where
- 9 sites in China
- Volunteers
- 3,281 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Lower Respiratory Tract Infections
Pneumococcal Carriage in Patients With Lower Respiratory Tract Infection (LRTI)
We are interested in developing new and better ways of diagnosing the cause of lower respiratory tract infections including pneumonia.
- Trial name
- NCT01861184
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Streptococcus Pneumoniae Carriage, Pneumococcal Colonization
Whole Genome-Based Surveillance of Nasopharyngeal Pneumococcal Carriage in Vietnamese Children
This hospital-based cross-sectional study aims to determine the prevalence and serotype distribution of nasopharyngeal Streptococcus pneumoniae carriage among children aged 2-59 months hospitalized with acute respiratory symptoms…
- Conditions
- Streptococcus Pneumoniae Carriage, Pneumococcal Colonization, Acute Respiratory Symptoms
- Trial name
- NCT07562529
- Where
- Vietnam
- Volunteers
- 530 people
- Sponsor
- Phuc Huu Phan
Pneumococcal Infections
Long-term Impact of Pneumococcal Conjugate Vaccine on Carriage
Pneumococcus is a major cause of morbidity and mortality. In 2000, a pneumococcal conjugate vaccine (PCV) was licensed for use in children and is now part of the routine childhood vaccine schedule.
- Trial name
- NCT00294021
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pneumococcal Disease, Pneumococcal Carriage
Carriage to Assess Protection of New Pneumococcal Vaccines - PCV15
Streptococcus pneumoniae (pneumococcus) is a bacterium that causes just under four million serious infections every year. It is normal for pneumococcus bacteria to live in the noses of healthy adults and children as part of the…
- Trial name
- RATIONALE-15 (NCT06731374)
- Testing
- PCV15, Streptococcus pneumoniae serotype 3
- Where
- 2 sites in United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nursery
Streptococcus Pneumoniae Nasopharyngeal Carriage
Antibiotic consumption and antimicrobial resistance remain notoriously high in France, particularly among children below three years of age.
- Trial name
- NCT01485029
- Testing
- Nasopharyngeal (NP) aspirate
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Department of Clinical Research and Innovation
Pneumococcal Carriage
Mass Campaigns With Fractional Dose Pneumococcal Vaccines in Sub-Saharan Africa (fPCV)
The aim of this study is to assess the impact of a mass campaign with a single, fractional dose of Pneumosil®, a PCV10, on VT carriage.
- Trial name
- fPCV (NCT05175014)
- Testing
- PCV10 full dose, PCV10 fractional dose
- Where
- Niger
- Volunteers
- 44,618 people, healthy volunteers welcome
- Sponsor
- Epicentre
Infections, Streptococcal
Evaluation of a Vaccine for Reducing Ear and Lung Infections in Children
The purpose of this study is to 1) demonstrate the protective efficacy against acute otitis media (AOM), 2) assess safety of the GlaxoSmithKline (GSK) Biologicals' pneumococcal vaccine GSK2189242A in Native American infants aged…
- Trial name
- NCT01545375
- Testing
- Pneumococcal vaccine GSK2189242A, Prevnar 13®, PedvaxHIB®
- Where
- 5 sites in United States
- Volunteers
- 1,806 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nasopharyngeal Carriage of Streptococcus Pneumoniae
Pneumococcal Carriage, Serotypes, and Antibiotic Resistance in Malaysian Children: A Multi-Centre Study
The goal of this observational study is to determine the prevalence, serotype distribution, and antimicrobial resistance patterns of nasopharyngeal carriage of Streptococcus pneumoniae in Malaysian children aged ≤5 years…
- Trial name
- MY-PNEUMO2 (NCT07545876)
- Where
- 4 sites in Malaysia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Pneumococcal Carriage, Particulate Matter
Indoor Air Pollution (IAP) Carriage Study
Personal exposure to Indoor Air Pollution (IAP) is a known risk factor of severe pneumonia, which is the number one killer of children under five in developing countries.
- Trial name
- NCT01660659
- Testing
- Biomass Briquettes and Rocket stove
- Where
- The Gambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Infection
AMR of Streptococcus Pneumoniae Carriage Strains
This study looks at the usage of human antibiotics for treatment of animals in Bangladesh.
- Trial name
- NCT00198640
- Testing
- Antibiotic use
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pneumococcal Disease
A Study to Assess the Impact of Pneumococcal Conjugate Vaccination Programme on the Carriage of Pneumococci
A study taking swabs from the back of the nose (nasopharynx) to look at carriage of pneumococci.
- Trial name
- Pneucast (NCT01040143)
- Where
- 3 sites in United Kingdom
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Public Health England
Streptococcus Pneumoniae
Impact of the 7 Valent Pneumococcal Conjugate Vaccine (7vPCV) on Nasopharyngeal Carriage of Streptococcus Pneumoniae in Healthy Jordanian Infants
Nasopharyngeal (NP) colonization of S. pneumoniae in infants is generally acquired at approximately 4-6 months of age. Although there are differences in the prevalence and rank order of serotypes obtained from NP specimens and…
- Trial name
- 7vPCV (NCT00900978)
- Testing
- 7 valent pneumococcal conjugate vaccine (7v-PCV) - Prevenar
- Where
- Jordan
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- German-Jordanian University
Nasopharyngeal Carriage of S. Pneumoniae
Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage
The specific aim is to evaluate the impact of PCV13 as administered in the pediatric primary care clinic at Boston medical center on the serotype specific carriage of Streptococcus pneumoniae in children < 5.
- Trial name
- NCT01109108
- Where
- United States
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Pneumococcal Carriage
Pneumococcal Carriage Duration
Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence…
- Trial name
- NCT07748832
- Testing
- Oropharyngeal (OP) swab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Community-acquired Pneumonia
PCV13 Impact on Pneumococcal Nasopharyngeal Carriage Study
Prospective, observational, hospital based, nasopharyngeal carriage (NPC), vaccine effectiveness study Comparisons will be made in Filipino children, aged 8 weeks to ≤60 months of age at enrollment, who have been hospitalized…
- Trial name
- IMPACT (NCT05114902)
- Testing
- Nasopharyngeal swab
- Where
- Philippines
- Volunteers
- 451 people
- Sponsor
- Asian Foundation for Tropical Medicine Inc.
Pneumonia, Influenza, Human
The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study
The investigators are interested in examining the effect of the Live Attenuated Influenza (flu) Vaccine (LAIV) upon nasal carriage of bacteria called Streptococcus pneumoniae (also known as pneumococcus).
- Trial name
- LAIV/EHPC (NCT03502291)
- Testing
- Study one: LAIV + Inoculation, Study two: Inoculation + LAIV
- Where
- United Kingdom
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Otitis Media, Febrile Illness
Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life
HYPOTHESES: 1. That infants receiving PHiD-CV10 as a booster at 12 months of age, compared to controls having no PHiD-CV10 booster (i.e.
- Conditions
- Otitis Media, Febrile Illness, Cough, Lower Respiratory Tract Infection
- Trial name
- PREV-IX_B (NCT01735084)
- Testing
- Prevenar13, Synflorix
- Where
- Australia
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research